A5023597701- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- Mass Spectrometry Techniques and Applications
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Atomic and Subatomic Physics Research
- Dendrimers and Hyperbranched Polymers
- Supramolecular Self-Assembly in Materials
- Pickering emulsions and particle stabilization
- Lipid Membrane Structure and Behavior
- Cellular Mechanics and Interactions
- Click Chemistry and Applications
- Advanced Biosensing Techniques and Applications
- Chemical Synthesis and Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Boron Compounds in Chemistry
- Planarian Biology and Electrostimulation
- Biosensors and Analytical Detection
- Genetics, Aging, and Longevity in Model Organisms
- Nanomaterials for catalytic reactions
- Crystallography and molecular interactions
Jawaharlal Nehru Centre for Advanced Scientific Research
2017-2024
Materials Science & Engineering
2018-2021
National Brain Research Centre
2017
In a three-dimensional (3D) representation, each protein molecule displays specific pattern of chemical and topological features, which are altered during its misfolding aggregation pathway. Generating recognizable fingerprint from such features could provide an enticing approach not only to identify these biomolecules but also gain clues regarding their folding state the occurrence pathologically lethal misfolded aggregates. We report here universal strategy generate fluorescent by...
Significance In many organisms axonal fragments can rejoin by self-fusion after neuronal injury. It is hypothesized that cell fusion would be an efficient way to repair functional loss this study, we tested hypothesis using the Caenorhabditis elegans sensory neurons are responsible for gentle touch sensation. We found between proximal and distal of injured posterior neuron (the lateral microtubule) promotes recovery in age-dependent manner. also discovered let-7 miRNA inhibits restoration...
Bioorthogonal strategies are continuing to pave the way for new analytical tools in biology. Although a significant amount of progress has been made developing covalent reaction based bioorthogonal strategies, balanced reactivity, and stability often difficult achieve from these systems. Alternatively, despite being kinetically beneficial, development noncovalent approaches that utilize fully synthetic stable components remains challenging due lack selectivity conventional interactions...
Abstract A solvent responsive dynamic nanoscale metal‐organic framework (NMOF) [Zn( 1 a )(H 2 O) ] has been devised based on the self‐assembly of Zn II and asymmetric bola‐amphiphilic oligo ‐( p ‐phenyleneethynylene) (OPE) dicarboxylate linker having dodecyl triethyleneglycolmonomethylether (TEG, polar) side chains. In THF solvent, NMOF showed nanovesicular morphology ( NMOF‐1 ) with surface decorated water methanol, exhibited inverse‐nanovesicle NMOF‐2 nanoscroll NMOF‐3 morphology,...
Cells at disease onset are often associated with subtle changes in the expression level of a single or few molecular components, making traditionally used biomarker-driven clinical diagnosis challenging task. We demonstrate here design DNA nanosensor array multichannel output that identifies normal pathological state cell based on alteration its global proteomic signature. Fluorophore-encoded single-stranded (ssDNA) strands were coupled via supramolecular interaction surface-functionalized...
Specific yet dynamic interaction in cucurbit[7]uril (CB[7]) system was used to obtain programmable fluorescence blinking with necessary brightness and frequency enable two-dimensional (2D) 3D super-resolution imaging of proteins cells.
Barcoding provides abilities to learn about individual species within an apparently homogeneous population. We describe a light-mediated multiplexed cellular barcoding strategy through spatial programming of cucurbit[7]uril molecular recognition.
The positive outcome of any therapeutic molecule requires control over its delivery rate. When delivered without control, administration large doses is required to stimulate a effect, frequently leading increased toxicity or undesirable side effects. Recent advances introduced "smart" materials that actively release drugs in response environmental stimuli. Although variety endogenous and exogenous triggers are reported, they either difficult lack tissue penetration depth. We report here...
Colloidal microcapsules based on supramolecular architectures feature attractive properties and offer new opportunities in diverse areas such as delivery, sensing, catalysis. Herein, we report a strategy to fabricate the colloidal membrane stimuli-responsive by utilizing cucurbit[7]uril-mediated interfacial host–guest molecular recognition. In contrast traditionally used cross-linking approach, this method exploits engineered interaction between nanoparticle ligand cucurbit[7]uril tune...
Abstract A solvent responsive dynamic nanoscale metal‐organic framework (NMOF) [Zn( 1 a )(H 2 O) ] has been devised based on the self‐assembly of Zn II and asymmetric bola‐amphiphilic oligo ‐( p ‐phenyleneethynylene) (OPE) dicarboxylate linker having dodecyl triethyleneglycolmonomethylether (TEG, polar) side chains. In THF solvent, NMOF showed nanovesicular morphology ( NMOF‐1 ) with surface decorated water methanol, exhibited inverse‐nanovesicle NMOF‐2 nanoscroll NMOF‐3 morphology,...
We present a facile route to synthesize gold nanoparticle-based colloidosomes via rapid and autonomous interfacial cross-linking using tetrazine click chemistry.
Fluorogenic probes that unmask fluorescence signals in response to bioorthogonal reactions are a powerful new addition biological imaging. They can significantly reduce background and minimize nonspecific signals, potentially enabling real-time, high-contrast imaging without the need wash out excess fluorophores. While diverse classes of highly refined synthetic fluorophores now readily available, integrating them into fluorogenic scheme still requires extensive design efforts customized...
Abstract Fluorogenic probes that unmask fluorescence signals in response to a bioorthogonal reaction are powerful new addition biological imaging. They can provide significantly reduced background and minimize non-specific signals, potentially allowing real-time high-contrast imaging without washing out excess fluorophores. While diverse classes of highly refined synthetic fluorophores readily available now, their integration into fluorogenic scheme still necessitates another level extensive...
Synthetic supramolecular host-guest complexes are inherently dynamic as they employ weak and reversible noncovalent interactions for their recognition process. This behavior allows chemistry to be employed various state of the art applications. Herein, we demonstrate use interaction enable nanoscopic imaging inside cells tissues. method exploits repetitive transient binding fluorescently labeled hexamethylenediamine (HMD) guest molecule complementary cucurbit[7]uril (CB[7]) host obtain...
Synthetic supramolecular host-guest complexes are inherently dynamic as they employ weak and reversible noncovalent interactions for their recognition process. This behavior allows chemistry to be employed various state of the art applications. Herein, we demonstrate use interaction enable nanoscopic imaging inside cells tissues. method exploits repetitive transient binding fluorescently labeled hexamethylenediamine (HMD) guest molecule complementary cucurbit[7]uril (CB[7]) host obtain...