Chemotherapeutic agents are not very effective in treating advanced endometrial cancers (ECs). Recent studies have demonstrated the immune evasion mechanism of tumors and possible remedies. Programmed cell death protein 1 (PD-1), programmed ligand (PD-L1), 2 (PD-L2) immunomodulator molecules that been focus research lung cancer, melanoma, renal cancer. However, there few concerning EC. This retrospective study aimed to determine PD-1, PD-L1, PD-L2 expression immunohistochemically EC, their...

Background/aimHodgkin Lymphoma (HL) is highly treatable, but new chemotherapy agents are needed for patients with progression or recurrence. CD47 regulates anti-phagocytic activity by signaling through the SIRPα (signal regulatory protein alpha) pathway on macrophages. This study aims to assess expression of in HL cases and explore its relationship Epstein-Barr Virus (EBV) status International Prognostic Index (IPI).Materials Methods120 diagnosed Classical HL, characterized presence Hodgkin...

Introduction: Bone marrow biopsy is widely used for the diagnosis of hematological diseases and malignancies that increase with age. We aimed to show contribution bone biopsies diagnostic process by comparing pathological diagnoses clinical preliminary in patient group aged 65 over. Materials Method: The study included 1,821 patients over who underwent between 2019 2024. Clinical diagnoses, demographic information, pathology reports departments requesting were accessed through information...

Background A fine needle aspiration biopsy ( FNAB ) is the most valuable diagnostic procedure for pre‐operative discrimination of benign and malignant nodules. The Bethesda System Reporting Thyroid Cytopathology provides standardised reporting cytomorphological criteria in smears. aim present study was to determine malignancy rates nodules with different cytology results evaluate value variants papillary thyroid carcinoma PTC ). Materials methods retrospective analysis 2534 cases 5784...

Abstract Purpose To determine whether early repeat fine needle aspiration biopsy (FNA) has an effect on adequate or atypia of undetermined significance (AUS) cytology rates in thyroid nodules with inadequate AUS result the first FNA. Methods Nodules patients who underwent due to insufficient between 2019–2022 were included. Data and ultrasonographic, cytological histopathological results recorded. Additionally, time two biopsies was noted. The called “initial” second “rebiopsy”. Five...

We aimed to compare cutting-needle biopsy (CNB) diagnoses with excisional of enlarging lymph nodes and determine the diagnostic value CNB.Out 291 cases that underwent CNB from between 2010 2016, 60 were included in study which pathological excised after CNB. Demographic information, pathology imaging reports, diameters length CNBs these obtained hospital registry system. Diagnoses biopsies then compared.According diagnosis, 7 (11.7%) benign 53 them (88.3%) malignant. 28 (53%) malignant...

Abstract Background We aimed to compare the cytology and histopathology results of hot, cold, warm nodules in patients who had thyroidectomy due toxic multinodular goiter (TMNG). Methods Five hundred nine thyroid from 413 operation with TMNG were included this retrospective study. The categorized as groups. compared. Results 509 grouped hot (n = 364 [71.5%]), cold 122 [24.0%]), 23 [4.5%]) according scintigraphy. Cytological evaluations follows: 80 (22%) nondiagnostic (ND), 259 (71.2%)...

The aim of this study was to evaluate the effects irisin in a murine model hind limb ischemia reperfusion (I/R).The mice were divided into four groups (n = 6 each group): control, irisin, (I/R), and irisin-ischemia (I-I/R). Irisin (0.5 µg.g-1, intraperitoneally [i.p.]) administered 30 min before I/R procedure. After 2 h 2.5 reperfusion, blood tissue samples taken for biochemical histopathological analysis. results analyzed by Kruskal-Wallis Mann-Whitney U-tests.There statistically...

The incidence of thyroid cancer is increasing which can be attributed in part to improved ultrasonography (US) methods and increased detection incidental carcinomas (ITC). We aimed compare ITC with nonincidental (NITC) this study.Retrospective analyses 906 individual patients who were operated for benign malignant disease had a final histopathological diagnosis carcinoma enrolled study. Preoperative US examination fine needle aspiration (FNA) biopsy results evaluated. tumor foci...

Glucagon-like peptide-1 (GLP-1) has been demonstrated to affect the oxidative stress status in several vitro, vivo and clinical studies. The aim of present study was evaluate effect a GLP-1 analogue, exenatide, on parameters apoptotic markers testicular cells an iron overload rat model. To obtain this model, animals were randomly divided into three groups (n=6/group). Rats control group received intraperitoneal injections saline. Intraperitoneal dextran (60 mg/kg/day) given Group FE for 5...

As histopathological findings of parathyroid carcinoma are not certain, the diagnosis tumors with degenerative changes may be difficult. In these cases, immunohistochemical markers beneficial. We aimed to research acceptability calcium-sensing receptor (CaSR), Galactin-3, Cyclin D1, and Ki-67 as helpful in cases which difficult diagnose.Those who had been diagnosed atypical adenoma between 2010 2015 were reevaluated. İmmunohistochemical applied this cases.About 21 adenoma, 14 10 carcinoma....

Aim: We aimed to evaluate the effectiveness of optical coherence tomography (OCT) in differential diagnosis anterior segment diseases such as ocular surface squamous neoplasia (OSSN) and pterygium. Methods: Patients who were pre-diagnosed with either OSSN (21) or pterygium (19) between January 2020 November 2022 included this retrospective study. Anterior photographs (AS-OCT) measurements obtained from each patient. Excisional incisional biopsy materials underwent pathological evaluation....

Objective The Bethesda classification was introduced in 2008 to provide standardisation the evaluation of thyroid fine needle aspiration cytology ( FNAC ). We compared diagnostic value pre‐Bethesda and systems differentiation benign malignant nodules. Methods Medical records patients who underwent a thyroidectomy between June 2007 2014 were reviewed retrospectively. Nodules evaluated with before March 2010 classified as (non‐diagnostic, benign, indeterminate, suspicious for malignancy...

Objective: Owing to their importance in cell proliferation cutaneous malignancies, we aimed immunohistochemically compare the expression profiles of p53 and Ki67 basal carcinoma (BCC) cases both a usual an unusual locations this study. Material Method:In study included 12 location BCC 21 location.Immunohistochemical antibodies were studied 33 paraffin-embedded tissue specimens carcinoma.We compared staining scores with clinicopathologic features. Results:The tumor size was found be greater...

The human epidermal growth factor receptor 2 (Her2/neu) signal pathway plays a significant role in the occurance of various solid tumor types. rate Her2/neu colorectal carcinoma (CRC) is not clearly elucidated. In this study, we discuss association between overexpression and clinicopathological parameters CRC. immunohistochemical (IHC) staining was performed on whole sections formalin fixed paraffin embedded tissues 100 CRC resections. Cases with score 3+ 2+ expressions were further...

Aim: Fullerenol, a water-soluble C60-fullerene, has been demonstrated to scavenge free radicals in vitro and vivo. The aim of the study was investigate effects fullerenol C60 on lower skeletal muscles rat model ischemia/reperfusion (I/R).Methods: After approval ethics committee, 30 Wistar Albino were divided into 5 groups with six animals per each as follows: Control (C), diabetes (D), diabetes+fullerenol (DF), diabetes+I/R (group DIR) I/R+fullerenol (DIR-F) groups. Streptozotocin...

Background We aimed to compare nonaspiration (NAS) and aspiration (AS) techniques in the evaluation of fine‐needle cytology lymph node (FNC‐LN) terms diagnostic adequacy cytologic material. Methods One hundred twenty‐three superficial cervical LNs 75 patients who underwent NAS AS‐FNC‐LN same visit were evaluated. Cytological results categorized as nondiagnostic. Results The rates malignancy 13.8% AS versus 16.3% technique, whereas nondiagnostic was detected 43.1% 25.2%, respectively ( P =...

Objective: Although classical Hodgkin lymphoma (cHL) has a relatively good prognosis, it also entails different treatment responses and involves patients who have clinical courses.Our aim was to investigate c-Myc, Bcl-2 EBV biomarkers in cHL their relationship with the IPS score.Material Method: c-Myc immunohistochemical staining EBER situ hybridization (EBER-ISH) applied paraffin sections of 94 cases diagnosed as cHL.These were classified into two groups low high symptoms according...

Gastrointestinal stromal tumors (GIST) are mesenchymal of the gastrointestinal tract. Although bleeding is one most symptoms seen in GIST, significant acute an unusual finding. Here in, three cases with due to GIST presented. Of these patients had duodenal, jejunal and other ileal GIST. The duodenal was detected by endoscopy while found capsule shown on magnetic resonance enterography. All underwent surgery diagnoses GISTs were confirmed histopathological evaluation.

Şeyletielloz (şeyletiella dermatiti), tüm dünyada, kedi, köpek ve tavşanlarda yaygın olarak bulunan cheyletiella akarlarının neden olduğu bir dermatittir.Doğal konağı kediler olan 'Cheyletiella blakei', özellikle evde beslenen infeste kedilerle yakın teması insanlarda infestasyona yol açar.İnsanlarda şeyletiellozis tanısı doktor veya veterinerin şüphelenmesi hayvanda akarların gösterilmesi ile konur.Şeyletiellozisten şüphelenilmez ise, parazitoz delüzyonu sanılabilir uzun süre tanı alamayabilir