A5049740269- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Inflammatory mediators and NSAID effects
- Bioactive natural compounds
- Natural product bioactivities and synthesis
Thammasat University
2022-2024
Polyphenols are a large family of naturally occurring phytochemicals. Herein, oxyresveratrol was isolated from ethanolic crude extracts Artocarpus lacucha Buch.-Ham., and chemically modified to derive its lipophilic analogues. Biological screening assays showed their inhibitory potency against cyclooxygenase-2 (COX-2) with very low cytotoxicity the MRC-5 normal cell lines. At catalytic site COX-2, docking protocols ChemPLP, GoldScore AutoDock scoring functions were carried out reveal...
Abstract Introduction The active compound ( E )‐1‐(3′,4′‐dimethoxyphenyl)butadiene (DMPBD) isolated from the rhizomes of Zingiber cassumunar Roxb. has potent anti‐inflammatory and anticancer activities. Although DMPBD is one promising drug candidates for phytomedicine, its limited stability impedes widespread use. For development new drugs, assessment their chemical essential, ensuring they maintain properties within specified limits throughout period production until Objective In present...
ABSTRACT Introduction Quantitative determination of pharmacologically active constituents in medicinal plants is critical for quality control. Due to the chemical complexity crude plant extracts, presence interfering compounds often problematic unambiguous quantitation designed bioactive compounds. Considering method quantification, quantitative NMR spectroscopy (qNMR) has gained substantial popularity as a powerful and effective technique both qualitative analyses natural products....