A5023496016- Electrochemical sensors and biosensors
- Carbon and Quantum Dots Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Advanced Nanomaterials in Catalysis
- Advanced battery technologies research
- Advanced biosensing and bioanalysis techniques
- Thermochemical Biomass Conversion Processes
- Microfluidic and Capillary Electrophoresis Applications
- Advanced NMR Techniques and Applications
- Bioactive natural compounds
- Computational Drug Discovery Methods
- Pharmacological Receptor Mechanisms and Effects
- Graphene research and applications
- Nanocluster Synthesis and Applications
- Natural product bioactivities and synthesis
- Lignin and Wood Chemistry
- Protein purification and stability
- Biofuel production and bioconversion
- Ion Channels and Receptors
- Inflammasome and immune disorders
- Supercapacitor Materials and Fabrication
- Analytical Chemistry and Chromatography
- Inflammatory mediators and NSAID effects
Thammasat University
2018-2025
University of Manchester
2017
Manchester Academic Health Science Centre
2017
Faculty (United Kingdom)
2017
NLRP3 is a receptor important for host responses to infection, yet also known contribute devastating diseases such as Alzheimer's disease, diabetes, atherosclerosis, and others, making inhibitors sought after. One of the currently in use 2-aminoethoxy diphenylborinate (2APB). Unfortunately, addition inhibiting NLRP3, 2APB displays non-selective effects on cellular Ca2+ homeostasis. Here, we chemical scaffold build series inhibitors, NBC series, which inhibit inflammasome vitro vivo without...
Noncovalent functionalization of graphene by carbohydrates such as β-cyclodextrin (βCD) has the potential to improve dispersibility and its use in biomedical applications. Here we explore ability approximate quantum chemical methods accurately model βCD conformation interaction with graphene. We find that DFTB3, SCC-DFTB PM3CARB-1 provide best agreement density functional theory (DFT) calculation relative energetics gas-phase conformers; however, remaining NDDO-based approaches considered...
Polyphenols are a large family of naturally occurring phytochemicals. Herein, oxyresveratrol was isolated from ethanolic crude extracts Artocarpus lacucha Buch.-Ham., and chemically modified to derive its lipophilic analogues. Biological screening assays showed their inhibitory potency against cyclooxygenase-2 (COX-2) with very low cytotoxicity the MRC-5 normal cell lines. At catalytic site COX-2, docking protocols ChemPLP, GoldScore AutoDock scoring functions were carried out reveal...