A5053555083- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Diabetes and associated disorders
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Pancreatic function and diabetes
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Diabetes Management and Research
- Neonatal Health and Biochemistry
- Metabolism and Genetic Disorders
- Diabetes Treatment and Management
- Central Venous Catheters and Hemodialysis
- Pediatric Urology and Nephrology Studies
- Biomedical Research and Pathophysiology
- Pregnancy and Medication Impact
- Renal and related cancers
- Urological Disorders and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Diet and metabolism studies
- Muscle and Compartmental Disorders
- Acute Kidney Injury Research
- Antibiotics Pharmacokinetics and Efficacy
- Complement system in diseases
Infectious Disease Research Institute
2023
Pediatric Nephrology of Alabama
1985-2012
University of Minnesota System
2002
University of Minnesota
1988-2001
University of Minnesota Medical Center
1983-1997
Twin Cities Orthopedics
1995
University of Padua
1994
Soonchunhyang University
1994
Saint Louis University
1992
Washington University in St. Louis
1990
Renal biopsies in 45 patients with insulin-dependent diabetes mellitus (IDDM) were examined by semiquantitative light microscopy and quantitative electron microscopic stereologic morphometry. In these 14 males 31 females, aged 13-52 yr, who had IDDM for 2.5-29 yr there was no strong relationship between either glomerular basement membrane (GBM) thickness or mesangial expansion duration of IDDM. There only a weak the GBM mesangium. Thus, thickening occur at rates that often differ from one...
We studied the effect of successful pancreas transplantation and consequent normoglycemia (mean total hemoglobin A1, 7.0 percent; range, 5.8 to 8.3) on visual function diabetic retinopathy in 22 patients with Type I diabetes mellitus (study group). Sixteen similar whom had been unsuccessful 12.0 8.0 18.0) served as a control group. The majority both groups advanced proliferative retinopathy. At mean follow-up 24 months we found no significant difference between rate progression retinopathy,...
A sustained decrease of plasma bilirubin concentrations occurred in homozygous recessive Gunn rats lacking the enzyme uridine diphosphate glucuronyltransferase following infusion into portal vein hepatocytes from heterozygous nonjaundiced possessing enzyme. Transplantation cells capable continuous production could be an effective mode therapy for congenital deficiency diseases.
The microvascular complications of diabetes mellitus may be caused, in part, by poor glycemic control. Diabetic patients who have received renal allografts new glomerular lesions that are manifested structurally increases mesangial and volume. Successful pancreas transplantation produces long-term normoglycemia provides a unique opportunity to evaluate the impact normalization blood glucose level on development typical transplanted kidneys. We obtained biopsy specimens from functioning 12...
Since several studies have suggested that a slight increase in urinary albumin excretion (microalbuminuria) is predictive of nephropathy patients with diabetes mellitus, we studied the relation to renal structure insulin-dependent (Type I) diabetes. Renal biopsy specimens were evaluated light- and electron-microscopical morphometric techniques 48 who had for 5 40 years excreted less than 200 mg per 24 hours. Patients Group I (n = 26) normal excretion, creatinine clearance, blood pressure;...
In a cross-sectional study, glomerular basement membrane (GBM) width, the volume fractions of mesangium (VvMes), its cell (VvCell) and matrix (VvMatx) components, surface density peripheral capillary (SvPGBM) were measured in renal biopsies from 187 nondiabetic living related cadaveric donors kidneys for transplantation 150 patients with insulin-dependent (type I) diabetes mellitus 1–41 yr duration. diabetic patients, was major factor expansion mesangium. However, both VvCell (0.11 ± 0.04)...
Diabetes was induced in Lewis rats with streptozotocin. Six to eight months later glomeruli showed mesangial thickening: IgG, IgM and C3 were seen large quantities the mesangium by immunofluorescent microscopy. Ten animals then had successful pancreatic transplantation resulting normal glucose insulin levels within one three weeks. Biopsies obtained first two weeks following demonstrated a significant reduction thickening staining for C3. Three four after no longer detected. A gradual IgG...
The immunohistopathology of the intrinsic basement membrane-associated antigens were examined in diabetic nephropathy. In early and moderate stages disease there was polyantigenic expansion all components mesangium, glomerular membrane (GBM), tubular (TBM) assessed by polyclonal antisera to collagen types IV V, laminin, monoclonal antibodies type fibronectin four other normal renal extracellular matrices (MBM10, 11, 12, 15). mesangium first increase V collagen. late disease, a diminution...
Rats with classic Goldblatt (two-kidney) hypertension had diabetes induced by streptozotocin. After four months of diabetes, glomeruli the unclipped kidney hypertensive diabetic rats markedly increased changes, including mesangial matrix thickening and immunoglobulin (IgG IgM) complement (C3) localization, when compared contralateral-clipped kidneys. Further, kidneys animals more IgG IgM staining than normotensive rats. Although clipped in less rats, this did not reach statistical...
One month following induction of diabetes with streptozotocin, one half diabetic and control rats underwent unilateral nephrectomy. Subsequently, all animals were studied respect to renal function glomerular alterations diabetes. Blood pressure levels similar in animals. Diabetic nephrectomy had but elevated serum creatinine lower clearance values as compared the intact rats. However, on a per kidney basis higher At both three six months nephrectomy, markedly increased mesangial matrix...
We examined renal-transplant tissue from 12 diabetic and 28 nondiabetic patients who had a renal graft for at least two years. In 10 arteriolar hyalinosis lesions developed in the graft. six these involved both afferent efferent limbs of glomerular arterioles - pathological finding virtually diagnostic diabetes mellitus. all cases were present within five years transplantation. Only three hyaline vascular changes (P less than 0.001), which occurred only rare vessels, did not appear first...
This study was designed to define quantitatively the function of rat glomerular mesangium in uptake and processing intravenously administered protein macromolecules (radiolabeled aggregated human IgG, AHIgG-(125)I), relate this that general reticuloendothelial system, examine effects increased permeability on mesangial cell system.Mesangial localization IgG as demonstrated by immunofluorescent microscopy showed good correlation with concentrations AHIgG-(125)I preparations isolated...
Diabetes was induced in Lewis rats with streptozotocin. Six to nine months later glomeruli showed significant mesangial matrix thickening; by immunofluorescent microscopy large quantities of IgG, (β1C and some instances, IgM were seen a distribution. Sustained normoglycemia then achieved these animals successful pancreatic islet isotransplantation. Three following transplantation five had decreased while four no further progression glomerular lesions. All marked decrease β iC the mesangium....