A5057774745- Bone fractures and treatments
- Bone Tissue Engineering Materials
- Bone health and osteoporosis research
- Craniofacial Disorders and Treatments
- Connective tissue disorders research
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Elasticity and Material Modeling
- Hip disorders and treatments
- Dental Implant Techniques and Outcomes
- Composite Material Mechanics
- Microfluidic and Capillary Electrophoresis Applications
- Anatomy and Medical Technology
- Advanced Mathematical Modeling in Engineering
- Neurogenetic and Muscular Disorders Research
- Surface Modification and Superhydrophobicity
- Periodontal Regeneration and Treatments
- Total Knee Arthroplasty Outcomes
- Prosthetics and Rehabilitation Robotics
- Bone and Dental Protein Studies
- Cellular Mechanics and Interactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Heterotopic Ossification and Related Conditions
Universidad de Huelva
2016-2024
Universidad de Sevilla
2014-2023
Instituto de Biomedicina de Sevilla
2023
3D-printed bioceramic scaffolds have gained popularity due to their controlled microarchitecture and proven biocompatibility. However, high brittleness makes surgical implementation complex for weight-bearing bone treatments. Thus, they would require difficult-to-instrument rigid internal fixations that limit a rigorous evaluation of the regeneration progress through analysis mechanic-structural parameters. We investigated compatibility flexible with fragile ceramic implants, if mechanical...
Introduction Woven bone, a heterogeneous and temporary tissue in bone regeneration, is remodeled by osteoblastic osteoclastic activity shaped mechanical stress to restore healthy properties. Characterizing this at different length scales crucial for developing micromechanical models that optimize parameters, thereby controlling regeneration preventing non-unions. Methods This study examines the temporal evolution of properties distraction callus using nanoindentation, ash analysis, micro-CT...
For the monitoring of bone regeneration processes, instrumentation fixation is an increasingly common technique to indirectly measure evolution formation instead ex vivo measurements or traditional in techniques, such as X-ray visual review. A versatile instrumented external fixator capable adapting multiple processes was designed, well a wireless acquisition system for data collection. The design and implementation overall architecture described this work, including hardware, firmware,...
Less Invasive Stabilization System femoral plates are currently accepted as a suitable fixation technique for supra-intercondylar fractures. However, general agreement does not exist regarding the optimum design of this fixator type. Therefore, aim article is to reduce intrinsic complications by clarifying, from biomechanical point view, how number screws, screw connection type (unicortical or bicortical), structured position screws can influence outcome fracture site. These studies include...
Abstract In silico models of distraction osteogenesis and fracture healing usually assume constant mechanical properties for the new bone tissue generated. addition, these do not always account porosity woven its evolution. this study, finite element analyses based on computed tomography (CT) are used to predict stiffness callus until 69 weeks after surgery using 15 CT images obtained at different stages an experiment transport, technique in which is correct defects. Three approaches were...
Multiscale analysis has become an attractive technique to predict the behaviour of materials whose microstructure strongly changes spatially or among samples, with that controlling local constitutive behaviour. This is case, for example, most biological tissues—such as bone. approaches not only allow, better characterise behaviour, but also field-variable distributions (e.g., strains, stresses) at both scales (macro and micro) simultaneously. However, multiscale usually lacks sufficient...
Abstract Collagen is a ubiquitous protein present in regenerating bone tissues that experiences multiple biological phenomena during distraction osteogenesis until the deposition of phosphate crystals. This work combines fluorescence techniques and mathematical modeling to shed light on mechano-structural processes behind maturation accommodation-to-mineralization callus tissue. Ovine metatarsal calluses were analyzed through confocal images at different stages early process, quantifying...
Woven tissue is mainly present in the bone callus, formed very rapidly either after a fracture or distraction processes. This high formation speed probably responsible for its disorganized microstructure and this, turn, low stiffness. Nonetheless, singular volumetric composition of this may also play key role mechanical properties. The woven extracted from transport callus sheep was investigated compared with that lamellar cortical shell same bone. Significant differences were found mineral...
Abstract A novel fluorinated soft thermoplastic elastomer (sTPE) for microfluidics is presented. It allows the rapid fabrication of microfluidic devices through a 30‐second hot embossing cycle at 220°C followed by self‐sealing simple conformal contact room temperature, or with baking. The material shows high chemical resistance, particularly in comparison to polydimethylsiloxane (PDMS), many common organic solvents and can be rapidly micropatterned fidelity using variety master molds thanks...
Introduction Tissue engineering has emerged as an innovative approach to treat critical-size bone defects using biocompatible scaffolds, thus avoiding complex distraction surgeries or limited stock grafts. Continuous regeneration monitoring is essential in cases due the frequent appearance of non-unions. This work evaluates potential clinical use gait analysis for mechanical assessment a tissue alternative traditional and hardly conclusive manual radiological follow-up. Materials methods The...
Callus tissue exhibits a viscoelastic behavior that has strong influence on the distribution of stresses and their evolution with time and, thus, it can affect differentiation during distraction procedures. For this reason, deep knowledge be very useful to improve current protocols bone transport. Monitoring stress relaxation callus osteogenesis allows characterizing its behavior. Different procedures have been used in literature fit response given model force curve. However, these do not...