PURPOSE: To assess and compare the histopathological effects of ozone therapy and/or methylprednisolone (MPS) treatment on regeneration after crush type sciatic nerve injury. METHODS: Forty Sprague-Dawley male rats were randomly allocated into four groups. Four groups received following regimens intraperitoneally every day for 14 days formation injury nerve: Group I: (20mcg/ml); II: (2mg/kg); III: (20 mcg/ml) IV: isotonic saline (0.9%). The histomorphological evaluation was made biopsies...

This study aims to assess the effects of systemic medical ozone (O3) application and compare its with hyperbaric oxygen (HBO) therapy for preventing avascular necrosis femoral head in a rat model. A total 50 male Wistar albino rats were divided into six groups including five each control sham-operated group 10 remaining four groups: (i) group, (ii) (iii) (iv) intraperitoneal given (v) HBO (vi) group. We surgically induced osteonecrosis by cutting ligamentum teres placing tight ligature...

Sciatic nerve injury (SNI) is a common model for studying peripheral damage and regeneration. This study investigates the complications associated with acute (ANI) by laceration of sciatic in rats including infection, edema, cannibalism, evaluates effectiveness therapeutic interventions to modulate observed complications. For this purpose eighteen female wistar albino were divided into three groups: control, sham-operated, ANI. The ANI induced dissection repair right nerve. Post-surgical...

The aim of this study is to determine the therapeutic effects pomegranate seed oil, which a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia reperfusion injury in rats.Fifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, 2; Ischemia, 3; Ischemia + Reperfusion, 4; Pomegranate 0,32 ml / kg (IP), 5; 0.64 kg, 6; reperfusion, 7; 0,64 reperfusion. Three hours after ischemia 3 was terminated.While NADPH oxidase activity, MDA TNF-α...

Alcoholic liver disease is an important health problem which reversible during early stages of damage, but becomes permanent with time. Nowadays, many studies focus on various agents that prevent, reduce or slow the progression toxic effects alcohol. In our study, we investigated efficiency ozone and selenium against oxidative damage in a model alcohol-induced damage.Forty-eight female Wistar Albino rats between 4 6 months age weighing 190-250 g were included study used as models alcohol...

Introduction: Feeding habits and environmental factors may rival genetic susceptibility as etiological related to various cancers. Humans are continuously exposed many synthetic food additives, one of which is sodium nitrite (NaNO2). There a direct correlation between increases in consumption nitrite-treated products incidence tissue damage, hepatotoxicity, nephrotoxicity some types cancer. The objective this study was investigate the protective effects Trigonella foenum-graecum (TFG) on...

Purpose: To compare the preventive effects of N-acetyl cysteine (NAC), ozone preconditioning and treatment against contrast-induced nephropathy (CIN) in an experimental rat model. Methods: Thirty adult male Wistar rats were randomly distributed into five groups (n=6 for each group). Group I served as control II had only contrast agent, while III received NAC IV intraperitoneal 6 hours before after introduction agent. Ozone was applied 5 days agent introduced V. After induction CIN, compared...

Objective: Vitamin B12 deficiency can be seen in the cases with sleeve gastrectomy.Because chief factor vitamin is gastric atrophy, we aimed to evaluate effect of atrophy on postoperative levels patients who underwent gastrectomy.Material and methods: Sixty were included this study.Vitamin compared presence before operation after supplementation.Results: Atrophy was observed 37 (61.7%) cases; 23 (38.3%) had no atrophy.There a statistically significant difference between (p = 0.024).Despite...

Purpose: To evaluate the effect of amniotic fluid in liver preservation organ transplantation, and compare it with standard solutions. Methods: The groups consisted Group 1: Ringer Lactate (RL) group, 2: HTK 3: UW 4: AF group. livers rats from 1, 2, 3, 4 were perfused placed into falcon tubes containing RL, HTK, UW, solutions at +4‎°C, respectively. stored for 12 hours refrigerator +4°C. Tissue samples taken 6th 12th histopathological examinations livers, storage biochemical analyzes hours....

Purpose This experimental sepsis model created with Escherichia coli aimed to investigate the histopathological effects of two different doses ozone combined antibiotherapy on lung tissue. Methods Rats were divided into 5 groups. Then was induced intraperitoneally in first 4 The 1st group treated cefepime, 2nd and 3rd groups cefepime at a dose 0.6 mg/kg 1.1 mg/kg. Lung tissue sections stained hematoxylin-eosin assessed under light microscope scored between 0-4 terms findings. Results In...

Lipocalin-2 has an important role in tumor progression, invasion, and metastasis. However, its prostate cancer remains unclear. The objective of this study is to determine the expression level lipocalin-2 human tissues evaluate relationship between clinicopathologic parameters including response docetaxel treatment, Gleason score, progression-free survival (PFS), overall (OS). We retrospectively analyzed paraffin-embedded tissue sections from 33 metastatic castrate-resistant (mCRPC) patients...

Purpose: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. Methods: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects allocated 3 groups: Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) high (300 doses AA addition to sevoflurane, respectively. Rhabdomyolysis myohemoglobinuric ARF was formed by intramuscular administration glycerol upper hind...

Liver biopsies such as tru-cut (sharp needle) and fine-needle aspiration cytology (FNAC) are the most commonly preferred techniques to detect grade stage of certain liver diseases. In this study, we aimed compare efficiency USG-guided biopsy in an experimental alcoholic disease model.Thirty-six female Wistar albino rats, 4-6 months old, weighing from 190 250 g, were used study. The animals randomly divided into six equal groups: G1 (control), G2 (tru-cut control), G3 (FNAC G4 (Alcoholic...

Aim: Today, complaints about the upper gastrointestinal system are frequently encountered among reasons for referral to health facilities.The most effective method evaluating these symptoms is endoscopic examination and histopathologic evaluation.In our study, we aimed evaluate gastric biopsy evaluations performed in Kars province histopathologically.Material Method: Between 2014 2016, 1457 patients who applied hospital underwent stomach were included study.Analysis was with SPSS 20.0...

Objective: Vitamin B12 deficiency can be seen in the cases with sleeve gastrectomy.Because chief factor vitamin is gastric atrophy, we aimed to evaluate effect of atrophy on postoperative levels patients who underwent gastrectomy.Material and methods: Sixty were included this study.Vitamin compared presence before operation after supplementation.Results: Atrophy was observed 37 (61.7%) cases; 23 (38.3%) had no atrophy.There a statistically significant difference between (p = 0.024).Despite...