A5050515199- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and genetic disorders
- Barrier Structure and Function Studies
- Photoacoustic and Ultrasonic Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Non-Invasive Vital Sign Monitoring
- Cell Adhesion Molecules Research
- Optical Imaging and Spectroscopy Techniques
- Neural dynamics and brain function
- Infrared Thermography in Medicine
- Ultrasound and Hyperthermia Applications
- Gastroesophageal reflux and treatments
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Head and Neck Surgical Oncology
- Neurological Disease Mechanisms and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Acute Ischemic Stroke Management
University of Oulu
2018-2024
Biocenter Finland
2020
Abstract Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C expression, has raised interest their possible involvement Alzheimer’s disease (AD). Here we find APdE9 and 5xFAD mouse models AD, amyloid-β (Aβ) is confined to blood dLV morphology or function not altered. The induction sustained atrophy hyperplasia AD mice by blocking overexpressing C, impaired improved, respectively, macromolecular...
Collagen type XVIII (COL18) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of COL18 would result blood-brain barrier (BBB) breakdown, pathological alterations small arteries and capillaries neuroinflammation as found cerebral vessel disease (CSVD) (ii) such changes may be associated with remodeling synapses neural extracellular matrix (ECM). We that 5-month-old Col18a1
Inside the incompressible cranium, volume of cerebrospinal fluid is directly linked to blood volume: a change in either will induce compensatory other. Vasodilatory lowering pressure has been shown result an increase intracranial pressure, which, normal circumstances should return equilibrium by increased efflux. In this study, we investigated effect on fluorescent tracer absorption into systemic circulation. Blood was performed i.v. administration nitric oxide donor (sodium nitroprusside, 5...
Abstract Collagen XVIII (COL18A1) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of collagen would result blood-brain barrier (BBB) breakdown, pathological alterations small arteries and capillaries neuroinflammation as found cerebral vessel disease (CSVD) (ii) such changes may be associated with remodeling synapses neural extracellular matrix (ECM). We that 5-month-old Col18a1 -/- mice had elevated BBB permeability for mouse IgG...
The Monro-Kellie doctrine states that the sum of contents intracranial cavity is constant, and consequently dynamics blood cerebrospinal fluid (CSF) volumes should be in an anti-correlation relationship. This phenomenon helped to explain many abnormalities hypotension CSF depletion. We aimed validate same mice during a pressure (BP) lowering test. Eight 2–3-month-old C57/Bl6N (Charles River) female were used this study. both nicardipine hydrochloride sodium nitroprusside (SNP) infusion into...
Motivation: The astroglia-mediated circulation of metabolites and waste between cerebrospinal fluid (CSF) blood or lymph, recently termed the glymphatic system, is implicated in processes from autoimmunity to neurodegeneration. Goal(s): Many details CSF dynamics, particularly efflux routes brain periphery including nasal pathways as we examine here, remain be clarified. Approach: Here investigate living mice using 9.4-T vivo dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)....
Abstract Background Inside the incompressible cranium, volume of cerebrospinal fluid (CSF) is directly linked to blood volume: a change in either will induce compensatory other. Vasodilatory lowering pressure has been shown result an increase intracranial pressure, which, normal circumstances should return equilibrium by increased efflux. In this study, we investigated effect (BPL) on fluorescent CSF tracer absorption into systemic circulation. Methods BPL was performed i.v. administration...
Monitoring blood-brain barrier (BBB) opening is of great interest in terms brain drug delivery the treatment lymphoma and maybe future other diseases like dementia. A method involving BBB disruption (BBBD) by mannitol infusion has been developed University Portland, USA, then exploited Oulu Hospital primary CSN lymphoma. Proper crucial for treatment, yet there are no methods available its real-time clinical monitoring. Recently, we presented a combined using direct-current...
Enhancing brain fluid movement across blood barrier (BBB) has been recognized as a potential treatment of neurodegenerative diseases. Moreover, BBB opening is high interest also in drug delivery the tumors/cancers. However, efficient therapies which are based on still limited because insufficient understanding mechanisms and safety issues. Currently, there few promising methodologically diverse approaches. In this paper, we use functional near-infrared spectroscopy (fNIRS) for first time...
Abstract Background The pathological alterations of small arteries and capillaries defined as cerebral vessel disease (CSVD) are characterized by age-dependent blood-brain barrier (BBB) breakdown wall remodeling manifesting in occlusions perivascular bleeds. As collagen XVIII (Col18a1) is an abundant heparan sulfate proteoglycan vascular basement membranes, we focused on studying the role integrity neurovascular unit maintenance context CSVD. Methods In this study, examined BBB breakdown,...