A5003470043- Mosquito-borne diseases and control
- Bacterial biofilms and quorum sensing
- Autoimmune and Inflammatory Disorders Research
- Antimicrobial Peptides and Activities
- Respiratory viral infections research
- Cardiac Ischemia and Reperfusion
- Congenital heart defects research
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Tissue Engineering and Regenerative Medicine
- Bacterial Genetics and Biotechnology
- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Immune Cell Function and Interaction
- Virology and Viral Diseases
- Antimicrobial agents and applications
- Cardiovascular Disease and Adiposity
- Cardiac Health and Mental Health
- Health and Lifestyle Studies
- Cardiovascular Function and Risk Factors
- Legionella and Acanthamoeba research
- Cardiomyopathy and Myosin Studies
- Apelin-related biomedical research
Universidad Libre de Colombia
2020-2025
University of the Coast
2022
Universidad del Norte
2021
Universidad de La Sabana
2015-2018
ABSTRACT Del Nido cardioplegia (DNC), a blood‐and‐crystalloid solution containing high and low concentrations of potassium calcium, respectively, is used as single‐dose antegrade infusion to induce immediate cardiac arrest in the surgery patients with cardiovascular diseases requiring extracorporeal circulation. Adding cardioprotective molecules may further reduce damage‐triggered ischemia/reperfusion (I/R) injury. Angiotensin‐(1–9) (Ang‐(1–9)) angiotensin‐(1–7) (Ang‐(1–7)), members...
Currently, cardiovascular diseases are a major contributor to morbidity and mortality worldwide, having significant negative impact on both the economy public health. The renin–angiotensin system contributes high spectrum of disorders is essential for maintaining normal homeostasis. Overactivation classical one most important pathophysiological mechanisms in progression diseases. counter-regulatory an alternate pathway which favors synthesis different peptides, including Angiotensin-(1-7),...
Dengue vascular permeability syndrome is the primary cause of death in severe dengue infections. The protective versus potentially pathogenic role NS1 antibodies are not well understood. main goal this analysis was to characterize relationship between free concentration and antibody titers secondary infection order better understand presence duration complexes clinical
Background Respiratory syncytial virus (RSV) is a common cause of bronchiolitis in children under the age five. RSV infection proceeds by fusion viral envelope with target cell membrane, but it unclear whether occurs plasma or endosomal membranes. Methods Entry and/or was studied undifferentiated primary cultures human bronchial epithelial cells. Synchronization entry achieved attaching to membrane at temperatures 4°C 22°C. Cells which events had occurred were identified enzymatic action...
The development of cardiovascular pathologies is partly attributed to epigenetic causes, including histone methylation, which appears be an important marker in hearts that develop cardiac hypertrophy. Previous studies showed the demethylase JMJD2A can regulate hypertrophic process murine cardiomyocytes. However, influence on hypertrophy a human cardiomyocyte model still poorly understood. In present study, cardiomyocytes derived from induced pluripotent stem cells (iPSCs) were used....
Epigenetic changes induced by histone demethylases play an important role in differentiation and pathological cardiac cells. However, the of jumonji family development hypertrophy remains elusive. In this study, presence different cells was evaluated after with neurohormones. A cell line from rat cardiomyocytes used as a biological model. The phenotypic profiles cells, well expression demethylases, were studied through immunofluorescence, transient transfection, western blot, qRT-PCR...
Abstract: The use of cardioprotective strategies as adjuvants cardioplegic solutions has become an ideal alternative for the improvement post-surgery heart recovery. choice optimal cardioplegia, well its distribution mechanism, remains controversial in field cardiovascular surgery. There is still a need to search new and better methods during procedures. New techniques management complications cardioplegia have evolved with alternatives additives, each strategy provides tool neutralize...
Increasing thermogenesis in white adipose tissues can be used to treat individuals at high risk for obesity and cardiovascular disease. The objective of this study was determine the function EP300-interacting inhibitor differentiation (EID1), an muscle differentiation, induction beige adipocytes from mesenchymal stem cells (ADMSCs). Subcutaneous tissue obtained healthy women undergoing abdominoplasty. ADMSCs were isolated vitro , grown, transfected with EID1 or siRNA, induced after 48 h by...
Objective To define the relationship between chronic chikungunya post-viral arthritis disease severity, cytokine response and T cell subsets in order to identify potential targets for therapy. Methods Participants with were recruited from Colombia 2019–2021. Arthritis severity was quantified using Disease Activity Score-28 an Arthritis-Flare Questionnaire adapted arthritis. Plasma concentrations (interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ tumor necrosis...
Mesenchymal stem cells are a diverse population of with wide range potential therapeutic applications. In particular, from adipose tissue have the distinction being easily accessible and contain lot cells. ADMSCs can be induced to mature adipocyte activate energy expenditure upon treatment total PPAR γ agonists. Additionally these may respond cold by activating thermogenic program. present study, we determined effect partial agonism temperature reduction on phenotype metabolic activity human...
The primary objective of this research was to explore the link between sleep and flare pain associated with chikungunya virus (CHIKV) infection. secondary investigate if cytokines T regulatory (Treg) cells have an influence on relationship.A cross-sectional study performed using data collected in Barranquilla, Colombia, which enrolled patients without chronic arthritis a history Flare severity measured by version Outcome Measures Rheumatoid Arthritis Clinical Trials (OMERACT) questionnaire...
Objective Chikungunya virus (CHIKV) causes persistent arthritis, and our prior study showed that approximately one third of CHIKV arthritis patients had exacerbated associated with exercise. The underlying mechanism exercise-associated chikungunya flare (EACAF) is unknown, this analysis aimed to examine the regulatory T-cell immune response related flares. Methods In study, 124 Colombian a history infection four years were enrolled 113 cases serologically confirmed IgG used in analysis....
Bacterial resistance is one of the major global public health problems. In addition, virulence factors promoted multiple drug through cell-to-cell communications by molecules within microbial communities, denominated Quorum Sensing (QS). The regulation QS small appears as a therapeutic alternative use synthetic analogs agonists. present work developed construction series derivatives N-(2-(o-tolyl)-1,2,3,4-tetrahydroquinoline-4-yl) formamide (1a-h) via Povarov-type sequential reactions to...
Bacterial resistance is one of the major global public health problems. In addition, virulence factors promoted multiple drug through cell-to-cell communications by molecules within microbial communities, denominated Quorum Sensing (QS). The regulation QS small appears as a therapeutic alternative use synthetic analogs agonists. present work developed construction series derivatives N-(2-(o-tolyl)-1,2,3,4-tetrahydroquinoline-4-yl) formamide (1a-h) via Povarov-type sequential reactions to...
Resumen Los cambios epigeneticos inducidos por factores ambientales tienen cada dia mas relevancia en las enfermedades cardiovasculares. Uno de los componentes moleculares observados la hipertrofia cardiaca es reactivacion genes fetales causados diversas patologias que incluyen obesidad, hipertension arterial, estenosis valvular aortica, causas congenitas, entre otras. A pesar multiples investigaciones cuyo objetivo obtener informacion acerca esta patologia, su influencia estrategias...
Las enfermedades cardiovasculares (ECV) son la causa principal de morbimortalidad a nivel mundial, afectando especialmente población mayor 60 años, pueden manifestarse según su origen en enfermedad coronaria (infarto agudo miocardio, angina pectoris, insuficiencia cardiaca, y muerte súbita) cerebrovascular (accidentes cerebrovasculares eventos isquémicos transitorios). Varios factores riesgo asociados al desarrollo las ECV han sido descritos; los clásicos (modificables no modificables),...
La enfermedad por chikungunya se caracteriza ser una patología zoonótica que genera incapacidad considerable en los seres humanos, debilitando su salud y estado físico. artropatía ha demostrado un compromiso funcional, emocional de calidad vida las distintas poblaciones afectadas. A la fecha no existe consenso unificado para el tratamiento exitoso artritis crónica chikungunya. Se han utilizado diversos esquemas tratamiento, pero aún sin respaldo investigaciones clínicas integrales. Existen...
Abstract Respiratory syncytial virus (RSV) is the most frequent cause of bronchiolitis in children under five years age. No vaccines against this are currently available. RSV infection a cell initiated by fusion between virion membrane and cellular membrane, but it not clear if process takes place at plasma or within an endosome. Most such experiments have been traditional synchronization temperature 4°C, abnormal for animal cells one which homeostasis may be negatively affected. We compared...