A5022419157- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- 2D Materials and Applications
- Advanced Photocatalysis Techniques
- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- biodegradable polymer synthesis and properties
- MXene and MAX Phase Materials
- Electrospun Nanofibers in Biomedical Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Nanoparticle-Based Drug Delivery
- Advanced Sensor and Energy Harvesting Materials
- Dendrimers and Hyperbranched Polymers
- Biosensors and Analytical Detection
- Chalcogenide Semiconductor Thin Films
- Advancements in Transdermal Drug Delivery
- Graphene and Nanomaterials Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced Fiber Laser Technologies
- Polymer composites and self-healing
- Advanced biosensing and bioanalysis techniques
- Adaptive optics and wavefront sensing
- Nigella sativa pharmacological applications
- Molecular Junctions and Nanostructures
Guangzhou Medical University
2022-2025
Shenzhen University
2015-2024
Shenzhen Institutes of Advanced Technology
2015-2022
Chinese Academy of Sciences
2009-2022
Shenzhen University Health Science Center
2019-2022
University of California, Los Angeles
2022
South China University of Technology
2012-2021
National Research Center for Rehabilitation Technical Aids
2012-2021
Southern University of Science and Technology
2014
Institute of Modern Physics
2009
Although phosphorene has attracted much attention in electronics and optoelectronics as a new type of two‐dimensional material, in‐depth investigations applications have been limited by the current synthesis techniques. Herein, basic N ‐methyl‐2‐pyrrolidone (NMP) liquid exfoliation method is described to produce with excellent water stability, controllable size layer number, well high yield. Phosphorene samples composed one four layers exhibit layer‐dependent Raman scattering characteristics...
Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns the biodegradability well long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates interior BPQDs from oxygen water enhance photothermal...
Abstract Black phosphorus quantum dots (BPQDs) were synthesized using a liquid exfoliation method that combined probe sonication and bath sonication. With lateral size of approximately 2.6 nm thickness about 1.5 nm, the ultrasmall BPQDs exhibited an excellent NIR photothermal performance with large extinction coefficient 14.8 Lg −1 cm at 808 conversion efficiency 28.4 %, as well good photostability. After PEG conjugation, showed enhanced stability in physiological medium, there was no...
Abstract A titanium sulfonate ligand is synthesized for surface coordination of black phosphorus (BP). In contrast to serious degradation observed from the bare BP, BP after exhibits excellent stability during dispersion in water and exposure air a long period time, thereby significantly extending lifetime spurring broader application BP.
Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated thermosensitive hydrogel [poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide) (PDLLA-PEG-PDLLA: PLEL)] to produce new system postoperative cancer. The BP@PLEL exhibits excellent...
Poly(vinylpyrrolidone)-encapsulated Bi2 Se3 nanosheets with a thickness of 1.7 nm and diameter 31.4 are prepared by solution method. Possessing an extinction coefficient 11.5 L g(-1) cm(-1) at 808 nm, the ultrathin boast high photothermal conversion efficiency 34.6% excellent photoacoustic performance. After systemic administration, proper size surface properties accumulate passively in tumors enabling efficient imaging entire to facilitate cancer therapy. In vivo biodistribution studies...
Abstract Topical therapy is a favored route for treating skin cancers, but remain many challenges, such as low delivery efficiency, limited tumor tissue penetration, and unsatisfactory blood circulation. Here, self‐heating microneedle (MN) patch with multilevel structures, including dissolvable base rapid drug release, degradable tip sustained substrate described. The thermally enhanced release performance validated through both in vitro vivo experiments. High therapeutic efficacy can be...
A reliable surface-enhanced Raman scattering (SERS) substrate composed of two-dimensional (2D) MXene (Ti3C2Tx) nanosheets and gold nanorods (AuNRs) is designed fabricated for sensitive detection organic pollutants. The AuNRs are uniformly distributed on the surface 2D because strong electrostatic interactions, forming abundant SERS hot spots. MXene/AuNR exhibits high sensitivity excellent reproducibility in determination common dyes such as rhodamine 6G, crystal violet, malachite green....
Abstract A titanium sulfonate ligand is synthesized for surface coordination of black phosphorus (BP). In contrast to serious degradation observed from the bare BP, BP after exhibits excellent stability during dispersion in water and exposure air a long period time, thereby significantly extending lifetime spurring broader application BP.
We report a new paper-based surface enhanced Raman scattering (SERS) substrate platform contributed by poly(l-lactic acid) (PLLA) nanofibrous paper adsorbed with plasmonic nanostructures, which can circumvent many challenges of the existing SERS substrates. This PLLA has three-dimensional porous structure, extremely clean good hydrophobicity (contact angle is as high 133.4°), and negligible background interference under laser excitation. Due to strong electrostatic interaction between...
In breast cancer chemophotothermal therapy, it is a great challenge for the development of multifunctional nanoagents precision targeting and effective treatment tumors, especially metastasis. Herein, we successfully design synthesize black phosphorus (BP)-based nanoagent, BP/DTX@PLGA, to address this challenge. composite BP quantum dots (BPQDs) are loaded into poly(lactic-co-glycolic acid) (PLGA) with additional conjugation chemotherapeutic agent, docetaxel (DTX). The in vivo distribution...
Abstract The photochemical activity of black phosphorus (BP) in near‐infrared (NIR) light controlled situ biomineralization is investigated. Owing to the excellent NIR absorption, irradiation with not only promotes degradation BP into PO 4 3− , but also enhances chemical accelerate reaction between and Ca 2+ promote biomineralization. Mineralization hydrogels demonstrated by preparation incorporated hydrogel (BP@Hydrogel) which delivers greatly improved performance under illumination....
Abstract As new 2D layered nanomaterials, Bi 2 O Se nanoplates have unique semiconducting properties that can benefit biomedical applications. Herein, a facile top‐down approach for the synthesis of quantum dots (QDs) in solution is described. The QDs with size 3.8 nm and thickness 1.9 exhibit high photothermal conversion coefficient 35.7% good stability. In vitro vivo assessments demonstrate possess excellent photoacoustic (PA) performance therapy (PTT) efficiency. After systemic...
Abstract Recent strides in non‐invasive drug delivery have spurred innovation alternatives to traditional needle injections. Transdermal systems (TDDs) emerged as a particularly promising avenue, boasting minimal rejection rates, user‐friendly administration, and enhanced patient adherence. Beyond pharmaceuticals, TDDs show potential skincare cosmetics, leveraging their ability facilitate localized while minimizing systemic exposure. Nonetheless, the intricate physicochemical nature of skin...
One of the clinical challenges facing photothermal cancer therapy is health risks imposed by nanoagents in vivo. Herein, a (PTT) platform composed 2D material-based nanofibrous membrane as agent to deliver thermal energy tumors under near-infrared (NIR) light irradiation described. The membrane, which fabricated an electrospinning poly(l-lactic acid) (PLLA) loaded with bismuth selenide (Bi2Se3) nanoplates, exhibits very high conversion efficiency and long-term stability. Cell experiments...
Abstract The nonlinear optical property of topological insulator bismuth selenide (Bi 2 Se 3 ) is found to be well-tailored through ion irradiation by intentionally introducing defects. increase the modulation depth sensitively depends on careful selection condition. By implementing irradiated Bi film as an saturable absorber device for Q-switched wave-guide laser, enhanced laser performance has been obtained including narrower pulse duration and higher peak power. Our work provides a new...