A5102771880- Neuroscience of respiration and sleep
- Asthma and respiratory diseases
- Enzyme Catalysis and Immobilization
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Orthopedic Surgery and Rehabilitation
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Respiratory and Cough-Related Research
- Computational Drug Discovery Methods
- Bone fractures and treatments
- Obstructive Sleep Apnea Research
- Elbow and Forearm Trauma Treatment
- Non-Invasive Vital Sign Monitoring
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Protein Kinase Regulation and GTPase Signaling
- Animal testing and alternatives
- Monoclonal and Polyclonal Antibodies Research
- Neuroscience and Neuropharmacology Research
- Tuberculosis Research and Epidemiology
- Antioxidant Activity and Oxidative Stress
- Thermal Regulation in Medicine
- Fatty Acid Research and Health
- Amino Acid Enzymes and Metabolism
Ulster Hospital
2022
Albert Einstein College of Medicine
2020
Montefiore Medical Center
2018-2020
United States Military Academy
2014-2019
Murphy Oil Corporation (United States)
2018
National Institutes of Health
2017
GlaxoSmithKline (United States)
2007-2016
GlaxoSmithKline (United Kingdom)
2008-2015
Ipswich Hospital
2013
South College
1995-2009
Abstract Background MicroRNAs (miRNAs) are a recently discovered class of non-coding RNAs (ncRNAs) which play important roles in eukaryotic gene regulation. miRNA biogenesis and activation is complex process involving multiple protein catalysts involves the large macromolecular RNAi Silencing Complex or RISC. While phylogenetic analyses genes have been previously published, evolution itself has little studied. In order to better understand origin processing animals plants, we determined...
The pH of liver supernatant was lowered from 7.4 to 5.1, which removed 23% the soluble protein and 97% lipid-soluble phosphate, increased total ..cap alpha..-tocopherol transfer activity 1.3-fold specific rate 1.6-fold. This proportional time up 4 min concentrations 0.1 mg/ml. Fractionation 5.1-treated by gel filtration produced a single peak M/sub r/ = 34,000 alpha..-tocopherol-binding coincident with activity. this 316 pmol/min/mg protein, 9-fold purification over original untreated...
We have identified several series of small molecule inhibitors TrkA with unique binding modes. The starting leads were chosen to maximize the structural and mode diversity derived from a high throughput screen our internal compound collection. These optimized for potency selectivity employing structure based drug design approach adhering principles ligand efficiency affinity without overly relying on lipophilic interactions. This endeavor resulted in identification pan-Trk inhibitor that...
Background: Metastatic lesions in the periacetabular region can cause pain and immobility. Symptomatic patients are often treated surgically with a total hip replacement using various modified Harrington methods. These open surgical procedures confer inherent risks. Prolonged recovery potential complications may delay adjuvant radiation systemic therapy. Methods: We describe novel technique for acetabular reconstruction. Three large-bore cannulated screws placed percutaneously under...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDamnacanthal Is a Highly Potent, Selective Inhibitor of p56lck Tyrosine Kinase ActivityConnie R. Faltynek, Joseph Schroeder, Patricia Mauvais, Deborah Miller, Su Wang, Dennis Murphy, Ruth Lehr, Marian Kelley, Alan Maycock, and Cite this: Biochemistry 1995, 34, 38, 12404–12410Publication Date (Print):September 26, 1995Publication History Published online1 May 2002Published inissue 26 September...
A technique is described for the intratracheal aerosolization of endotoxin into rat. Using a miniaturized nozzle within tracheal lumen to optimize uniform distribution 0.5 ml an solution (7 mg/kg) was aerosolized and dispersed throughout lung. Time course studies pulmonary function histological changes revealed marked functional morphological by 24 h. Histopathologic consisted widespread oedema diffuse neutrophilic alveolitis. At same time, there were significant decreases in tidal volume,...
Directed evolution has become an important enabling technology for the development of new enzymes in chemical and pharmaceutical industries. Some most interesting substrates these enzymes, such as polymers, have poor solubility or form highly viscous solutions are therefore refractory to traditional high-throughput screens used directed evolution. We combined digital imaging spectroscopy a solid-phase screening method screen enzyme variants on problematic efficiently show here that specific...
The purpose of this project was to determine if com mercially available braces could be shown produce objective evidence medial stabilization the knee. Commercially athletic were evaluated for their effect on abduction forces applied a cadaver knee with no instability and experimentally created instability. Under computer control, while simultaneous data ob tained from an electrogoniometer transducers ap plied anterior cruciate ligament superficial collateral at 0°, 15°, 30° flexion. Our...
Abstract Radial shortening and ulnar lengthening are two accepted surgical methods for treating Kienbock's disease. The effect of these procedures on the pressure within distal radioulnar joint between head sigmoid notch radius was experimentally evaluated in six fresh cadaver forearms. led to increased at articulation caused shifting location center distally notch. displacement radial fragment time shortening, however, decreased peak pressures. Based experimental data, can be expected alter...
Abstract The known effects of drugs from a variety pharmacologic/therapeutic classes on the respiratory system and worldwide regulatory requirements support need for conducting evaluations in safety pharmacology. objective these studies is to evaluate potential cause secondary pharmacologic or toxicologic that influence function. Changes function can result either alterations pumping apparatus controls pattern pulmonary ventilation changes mechanical properties lung determine transpulmonary...
Disruption of the medial supporting structures knee occurs commonly in contact sports such as Amer ican football and lacrosse. A limited number clinical laboratory studies currently document effec tiveness bracing. The purpose this project was to determine if commercially available bracing could be shown produce objective evidence stabili zation knee. Our model involves use a cadaver lower extremity with fixed foot sus pended femur free lateral impact load applied simulating clipping injury....