These guidelines were commissioned by the British Association of Dermatologists and therapeutics subcommittee. Members committee are N.H.Cox (Chairman), A.S.Highet, D.Mehta, R.H.Meyrick Thomas, A.D.Ormerod, J.K.Schofield, C.H.Smith J.C.Sterling. U.K. Cutaneous Lymphoma Group who have contributed include C.Benton, R.Cowan, C.Deardon, B.Hancock, H.Lucraft D.Slater.

Seven patients with nodular prurigo, five lichenified eczema and seven control volunteers were studied immunohistochemically using antisera to the pan-neuronal marker protein gene product 9.5 (PGP), neuropeptides calcitonin gene-related peptide (CGRP), substance P (SP), tyrosine hydroxylase (TH), vasoactive intestinal polypeptide (VIP) C-flanking region of neuropeptide Y (C-PON). PGP-, CGRP- SP-immunoreactivities also evaluated image analysis quantification, data compared by statistical...

Histopathological criteria were used to classify twenty-four patients with chronic urticaria into three groups, which then studied establish whether circulating immune complexes (CICs), complement activation and deposition of immunoreactants are confined urticarial vasculitis. Group I (three patients) had classical vasculitis, two these showed hypocomplementaemia evidence C3 conversion in lesional uninvolved skin. Ten (group 2) a dense perivascular mixed-cellular infiltrate normal or raised...

The authors have analyzed the configuration of immunoglobulin (Ig) and β, γ δ T-cell receptor (TCR) genes in DNA extracted from skin, lymph nodes, peripheral blood mononuclear cells obtained 41 patients with mycosis fungoides (MF), 14 Sezary syndrome, 13 benign inflammatory dermatoses. No discrete rearranged bands (DRB) were detected In tissue 19 MF DRB β γ, but not TCR probes. Only one patient had a rearrangement germ line genes. multiple biopsies DRB, when present, identical different...

Sun-exposed and sun-protected skin obtained at post mortem from the nape of neck in 14 subjects was immunostained using antisera to elastic, lysozyme, amyloid P component, plasma protease inhibitors alpha-I antitrypsin, amichymotrypsin alpha-2 macro-globulin. Both normal clastic fibres skin, clastosis sun-exposed were positively for elastin, lysozyme component. Collagen unstained. No immunostaining elastic or elastosis with antichymotrypsin macroglobulin. It concluded that does contain...

We have reviewed the histopathological features of 11 patients with pustular drug eruptions. Two main histological patterns were seen. Eight cases revealed toxic pustuloderma presence spongiform intraepidermal pustules in association papillary oedema and a mixed inflammatory cell infiltrate around upper dermal blood vessels. Pustules present at different levels within epidermis. The other three exhibited leucocytoclastic vasculitis neutrophil collections both below One case showed continuity...

A study was undertaken of new referrals by GPs to a dermatology clinic in district general hospital over 6-month period. Six hundred and eighty-six consecutive one consultant were analysed for diagnostic accuracy requirement referral. Only 47% referral letters contained the correct diagnosis. Viral warts psoriasis best diagnosed (82 78%, respectively), but seborrhoeic dermatofibromas caused difficulty (22 19%, respectively). Cutaneous malignancy correctly 45% referrals, eczema, commonest...

Journal Article Solitary morphoea profunda Get access S.J. WHITTAKER, WHITTAKER Dermatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K. Dr Sean Whittaker, Du Cane Road, London Search for other works by this author on: Oxford Academic Google Scholar N.P. SMITH, SMITH St. John's Hospital Diseases of the Skin, R. RUSSELL JONES† British Dermatology, Volume 120, Issue 3, 1 March 1989, Pages 431–440, https://doi.org/10.1111/j.1365-2133.1989.tb04171.x Published: 01 1989

A female patient with disfiguring lupus erythematosus profundus (LEP) from the age of 13 years was found to have an isolated partial C4 deficiency, reduced levels both allotypes, C4A and C4B. genetic basis for hypocomplementaemia confirmed by a family study complement HLA types which revealed heterozygous null alleles C4B in proband. Marked improvement her cutaneous lesions occurred thalidomide.

We describe the clinical, histological and immunopathological features of four female patients with bullous eruption systemic lupus erythematosus (bullous SLE). Three had circulating anti-basement membrane zone (BMZ) antibodies, Western blot analysis in two cases revealed binding to type VII collagen. Immunoelectron microscopy one these demonstrated deposition antibody lamina densa sublamina regions, thus sharing epidermolysis bullosa acquisita (EBA). The vesiculobullous lesions developed 8...

Four endothelial cell markers, two selective cytokeratin markers and a monoclonal smooth muscle antibody (SMA) were employed in the assessment of 19 cases cutaneous angiosarcoma classified according to their degree tumour differentiation. No labelling was seen for SMA or with MNF116 CBL170. Expression factor VIII-related antigen tumours positivity CD34 (QBend 10 antibody) found four tumours. By contrast pan-endothelial marker Ulex europeaus agglutinin 1 (UEA-1) CD31 JC70A labelled all...

The histogenesis of mammary and extramammary Paget's disease has been studied by immunohistochemical staining paraffin-embedded tissue using a panel epithelial cell markers, which react with secretory or ductal epithelium, but not stratified epithelium. These markers included monoclonal antibody E29 to membrane antigen EMA, the cytokeratin marker CAM 5.2 three new antibodies raised human milk fat globule (LICR-LON-TW19 H.10.A) bladder cancer line (3.77). findings demonstrate that both are...

The two cases reported in this paper allow the differentiation pagetoid reticulosis from solitary lesions of mycosis on basis clinical, histological ultrustructural immunohistochemical and enzyme histochemical studies. first patient presented with a slowly growing asymptomatic scaly plaque 30 years duration Histology lesion was typical reticulosis. Immunohistochemical studies showed that abnormal cells present cutaneous infiltrate were not T lymphocytes ultrastructural suggested these...

Paraproteinaemia may be associated with xanthomatous skin deposits and these can arise in the absence of elevated lipid levels. Two cases benign monoclonal gammopathy diffuse plane xanthomatosis are reported. Case 1 exhibited hypolipidaemia a functional deficiency C1 esterase inhibitor. 2 showed normal lipoprotein profile, abnormal platelet aggregation, cutaneous vasculitis evidence complement consumption via classical pathway. The significance abnormalities is discussed.

We report a patient with an eccrine carcinoma who developed localized blistering which clinically resembled pemphigoid, histologically showed subepidermal features of both dermatitis herpetiformis and bullous responded to dapsone exhibited linear IgA deposition on direct immunofluorescence. The nosological position patients is not clear. A review the literature reveals that in adults may occur three separate situations: herpetiformis, pemphigoid third condition our case example best termed...

We report human immunodeficiency virus (HIV)-associated eosinophilic folliculitis in a previously well 40-year-old Portuguese lady. This condition, although similar to Ofuji's disease, has distinguishing features which allow the two be differentiated. To best of our knowledge, this is first reported case HIV-associated female and patient whom HIV was heterosexually transmitted. Our also unusual being, we believe, only second eruption presenting feature infection.

Cutaneous necrosis with microvascular calcification is a rare and serious complication of chronic renal failure has been given the sobriquet 'calciphylaxis'. We describe four dialysis-dependent patients proximal cutaneous who presented this distinctive clinical syndrome. All were women aged between 40 68, all developed widespread livedo reticularis followed by painful subcutaneous nodules which progressed to eschar-like lesions skin. Microvascular was seen on radiographs limbs, especially at...

Summary This is a case report of horse that developed haemopneumothorax as complication bronchoalveolar lavage procedure. The had exercise‐induced pulmonary haemorrhage prior to this event.

SUMMARY Two cases of recurrent erythema multiforme unknown aetiology are reported. The term ‘persistent’ is appropriate as the lesions recurred whenever steroid therapy was discontinued. Both patients were eventually controlled with azathioprine alone, and one patient required treatment for 3 years.