Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are considered among the most potent antiviral agents for treatment of chronic hepatitis B infection. We aimed to compare efficacy safety ETV TDF in nucleoside-naïve patients.Inclusion criteria were compensated patients who either e antigen (HBeAg)-positive or HBeAg-negative. Exclusion co-infection with C virus and/or HIV, concurrent malignancy, decompensated cirrhosis. Virological, biochemical, serological end-points at week 96 144...

Background Radiation therapy (RT) is a primary postsurgical treatment for breast cancer; however, it can cause acute radiation dermatitis (ARD), which severely impair quality of life. The aim this study was to identify predictive factors associated with moderate severe ARD. Materials and Methods In retrospective analysis, we utilized data from Chulabhorn Hospital’s Health Information System that collected between January 2017 December 2022. A oncology specialist assessed ARD in cohort 635...

Thailand has a high incidence of cholangiocarcinoma (CCA), particularly in the north and northeastern regions. Most CCA patients come at late, unresectable stage presently no optimal screening test for been established. We determined prevalence remote northern village explored if could lead to early detection survival benefits. A 5-year population-based study was started October, 2011 consented Thai individuals, aged 30–60 years. The program comprised blood testing, stool examination serial...

While favipiravir had been the standard anti-SARS-CoV-3 drug for COVID-19 treatment in Thailand, efficacy of is controversial. Andrographis paniculata extract (APE) inhibits viral entry, exhibits immunomodulatory effects, and proposes to have potential early-stage treatment.A randomized, double-blind, placebo-controlled trial was performed Thailand during June - September 2021. Non-severe patients were randomized 1:1 groups receiving 180 mg/day APE plus (APE-FPV group) or placebo...

Mass vaccination with a safe and effective vaccine may be the best way to control COVID-19 pandemic. Heterologous prime-boost CoronaVac AZD1222 vaccines increase immunogenicity elicited by either alone. This study sought compare of heterologous homologous prime-boost. From July 13 September 2, 2021, 88 participants were enrolled in study. Half (n = 44) assigned AZD1222/CoronaVac cohort half CoronaVac/AZD1222 cohort. Both cohorts had interval 4 weeks. A group 136 health care personnel who...

The CoronaVac vaccine is widely used in Thailand to combat the coronavirus disease 2019 (COVID-19) pandemic. limited immunogenicity of this a concern, especially because expanding delta variant outbreaks. A third boost may enhance antiviral immune responses. This non-inferiority randomized controlled trial evaluated and safety an intradermal (ID) fractional dose AZD1222 compared with those standard intramuscular (IM) dose. Participants were enrolled from August 9, 2021 13, at Chulabhorn...

Increasing morbidity and mortality from colorectal cancer is evident in recent years the developing Asian nations. Particularly Thailand most neighbouring low-income countries, screening colonoscopy not yet recommended nor implemented at national policy level.Screening was offered to 1,500 healthy volunteers aged 50-65 old who were registered into program between July 2009 June 2010. Biopsy surgery performed depending on identified lesions. Fecal immunochemical tests (FIT) additionally for...

Since the introduction of hepatitis B virus (HBV) vaccines, numbers HBV infections and complications have significantly decreased. However, evidence on whether primary vaccination infants confers lifelong immunity varies. We aimed to assess long-term among healthcare workers medical students, rate decline surface antigen antibodies (anti-HBs). Hepatitis status participants born after 1 January 1992 was reviewed at Chulabhorn Royal Academy, Thailand. Participants were stratified by intervals...

Coronavirus disease 2019 affected child health and impacted learning because of the resulting onsite school closures. This prospective cohort study included children aged 10-17 who received two 4 µg doses BBIBP-CorV administered intramuscularly 21-28 days apart. To assess vaccine safety, 36,808 participants were then followed with paper- web-based online questionnaire surveys that captured local systemic reactogenicities following administration on 1, 7, 30. Among participants, 76% (27,880)...

To evaluate quantitative hepatitis B surface antigen (qHBsAg) as a diagnostic marker for inactive carriers (ICs) and (HBsAg) seroclearance in e (HBeAg)-negative chronic (CHB) patients. We retrospectively studied 300 HBeAg-negative CHB patients with initial serum virus (HBV) Deoxyribonucleic acid (DNA) levels <2000 IU/mL. Serum HBV DNA alanine aminotransferase (ALT) were monitored every 6 months 24 months. ICs identified having persistent IU/mL normal ALT levels, whereas active (ACs) ≥2000...

Due to the vaccine's short supply and efficacy of a single dose ChAdOx1 (AZD1222) vaccine, many governments delayed interval between prime boost from 4 8-12 weeks. However, waning immune response in this period is concern. This study evaluated durability, contributing factors anti-RBD antibody concentration, reactogenicities after AZD1222 vaccine Thai population.

To determine the role of screening and surveillance hepatocellular carcinoma (HCC) in treatment-naïve chronic hepatitis B (CHB) patients.We recruited 2293 CHB patients (both males females; aged 20-65 years). All were screened underwent using abdominal ultrasonography (AUS) serum alpha-fetoprotein (AFP) assay every 6 mo. The diagnosis, staging treatment HCC followed American Association for Study Liver Diseases practice guidelines Barcelona Clinic Cancer guidelines. exclusion criteria...

ABSTRACT The effectiveness of neutralizing monoclonal antibodies against emerging variants with spike protein mutations has been limited. Early high-titer convalescent plasma therapy (CPT) tends to be effective and a potential treatment option for COVID-19 outpatient treatment. An open-label, 1:1, randomized controlled trial compared the efficacy high titer CPT favipiravir (CPT-FPV) versus sotrovimab. study aimed evaluate non-inferiority CPT-FPV sotrovimab in preventing hospitalization...

Colorectal adenomas are precursor lesions of colorectal adenocarcinoma. The transition from adenoma to carcinoma in patients with cancer (CRC) has been associated an accumulation genetic aberrations. However, criteria that can screen progression adenocarcinoma still lacking. This present study is the first attempt identify aberrations, such as somatic mutations, copy number variations (CNVs), and high-frequency mutated genes, found Thai patients. In this study, we identified genomic...

Adolescents can develop a severe form of Coronavirus disease 2019 (COVID-19), especially with underlying comorbidities. No study has examined the efficacy or effectiveness inactivated COVID-19 vaccines in adolescents. This single-center, prospective cohort was performed to evaluate safety and an vaccine adolescents using immunobridging approach at Chulabhorn Hospital. The key eligibility criterion healthy clinical condition stable pre-existing comorbidity. anti-receptor-binding domain...

SARS-CoV-2 is primarily transmitted within households, with massive healthcare system burdens. The role of inactivated vaccines and ChAdOx1 nCoV-19 vaccination in the prevention within-household transmission remains unknown.This observational case-control study tracked 408 polymerase chain reaction-confirmed index cases from April to September 2021. This aimed prove benefit vaccinated preventing transmissibility.A total 1178 household contacts were investigated. A 231 or vaccine, 177...

Abstract Background and Aim Cholangiocarcinoma (CCA) is an aggressive malignancy with rapid progression poor prognosis. Abdominal ultrasound surveillance may detect early‐stage improve surgical outcome. However, little data exist on the benefits of abdominal in populations at high risk for CCA development endemic area. This study compared survival outcomes patients recruited through program those presented to hospital independent surveillance. Methods The population‐based cohort was 4225...

Objective: This study aimed to evaluate the association between low fruit and vegetable consumption colorectal polyps. Methods: A retrospective was conducted among 1,228 participants aged 50-65 years who completed 2-time colonoscopy exams at first fifth year of a screening program. Consuming less than one serving daily rated as low. Colorectal polyps from findings were recognized in 3 types: hyperplastic, risk high adenomatous Results: The demonstrated prevalence (93.6%) (85.8%) consumption....

Immunogenicity after the CoronaVac vaccine remains uncertain, especially regarding infections with coronavirus variants of concern and waning immunity.This was a single-center, open-label clinical trial designed to assess immunogenicity safety BBIBP-CorV, AZD1222, or BNT162b2 as third vaccination. The key eligible criteria were individuals at least 18 years old who fully vaccinated two doses for 2-4 months. primary endpoint ratio geometric mean concentration (GMC) total anti-receptor binding...

Genetic variation in MTHFR gene might explain the interindividual differences reduction of DNA repaired and increase chromosome breakage damage. Nowadays, chromosomal rearrangement is recognized as a major cause lymphoid malignancies. In addition, association polymorphisms with aneuploidy was found several studies, making good candidate for leukemia etiology. Therefore, this study, we investigated common sequence variation, 677C>T 1298A>C 350 fixed cell specimens archived after analysis. The...

Chronic hepatitis B (CHB) infection-associated hepatocellular carcinoma (HCC) is a major health problem in Asian countries. Several HCC risk prediction models have been developed using either treated or untreated CHB patients. However, there limited validation of these scores and mixed patient cohort. This study analysed validated among 2208 patients who enrolled the surveillance programme Thailand during July 2010. The baseline clinical radiologic data were applied to calculate various...

Genetic variation in MTHFR gene might explain the interindividual differences reduction of DNA repaired and increase chromosome breakage damage. Nowadays, chromosomal rearrangement is recognized as a major cause lymphoid malignancies. In addition, association polymorphisms with aneuploidy was found several studies, making good candidate for leukemia etiology. Therefore, this study, we investigated common sequence variation, 677C&gt;T 1298A&gt;C 350 fixed cell specimens archived after...

Cholangiocarcinoma (CCA) or bile duct cancer is a rare type in developed countries, while its prevalence increased southeast Asia, affecting ~33.4 men and ~12.3 women per 100,000 individuals. CCA one of the most lethal types cancer. Neo-adjuvant adjuvant therapies have been shown to limited efficacy improving overall prognosis patients. Radiotherapy has reported prolong survival times patients with certain characteristics. The present study retrospectively evaluated medical records follow-up...

A good clinical prediction score can help in the risk stratification of patients with colorectal cancer (CRC) undergoing colonoscopy screening. The aim our study was to compare model performance binary logistic regression (BLR), polytomous (PLR), and classification tree (CART) between scores advanced neoplasia (ACN) asymptomatic Thai patients.We conducted a cross-sectional 1311 develop model. possible predictive variables included sex, age, body mass index, family history CRC first-degree...

ABSTRACT Introduction COVID-19 pandemic affects all populations worldwide, including adolescents. Adolescents can develop a severe form of COVID-19, especially with comorbidity underlying. The prior studies the mRNA vaccine showed excellent effectiveness in Therefore, this study aimed to evaluate safety and BBIBP-CorV immunobridging approach Thai Methods This single-center, prospective cohort compared immunogenicity after 2 doses BBIBO-CorV 21 days interval participants aged 12-17 years...