A5065479535- Spinal Cord Injury Research
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Folate and B Vitamins Research
- Nitric Oxide and Endothelin Effects
- Nerve Injury and Rehabilitation
- Stroke Rehabilitation and Recovery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Protease and Inhibitor Mechanisms
- Vagus Nerve Stimulation Research
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Muscle activation and electromyography studies
- Long-Term Effects of COVID-19
- Pain Management and Treatment
- Cardiovascular Function and Risk Factors
- Sulfur Compounds in Biology
- Cerebral Palsy and Movement Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular and exercise physiology
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Tracheal and airway disorders
University of Louisville
2014-2024
Neurological Surgery
2014-2024
Rehabilitation Institute of Michigan
2011-2021
Applied BioPhysics (United States)
2012
University of Louisville Hospital
2005-2011
Hyperhomocysteinemia decreases vascular reactivity and is associated with cardiovascular morbidity mortality. However, pathogenic mechanisms that increase oxidative stress by homocysteine (Hcy) are unsubstantiated. The aim of this study was to examine the molecular mechanism which Hcy triggers reduces bioavailability nitric oxide (NO) in cardiac microvascular endothelial cells (MVEC). MVEC were cultured for 0-24 h 0-100 microM Hcy. Differential expression protease-activated receptors (PARs),...
Disruption of motor and autonomic pathways induced by spinal cord injury (SCI) often leads to persistent low arterial blood pressure orthostatic intolerance. Spinal epidural stimulation (scES) has been shown enable independent standing voluntary movement in individuals with clinically complete SCI. In this study, we addressed whether scES configured activate lumbosacral networks can also modulate assessing continuous, beat-by-beat lower extremity electromyography during supine seven C5-T4...
This cohort study evaluates the feasibility of daily customized epidural stimulation configurations targeted for cardiovascular function in individuals with chronic, cervical motor-complete spinal cord injury.
Homocysteine (Hcy) induces matrix metalloproteinase (MMP)-9 in microvascular endothelial cells (MVECs). We hypothesized that the ERK1/2 signaling pathway is involved Hcy-mediated MMP-9 expression. In cultured MVECs, Hcy induced activation of ERK, which was blocked by PD-98059 and U0126 (MEK inhibitors). Pretreatment with BAPTA-AM, staurosporine (PKC inhibitor), or Gö6976 (specific inhibitor for Ca(2+)-dependent PKC) abrogated ERK phosphorylation, suggesting role Ca(2+) PKC Hcy-induced...
Abstract An elevated level of homocysteine (Hcy) limits the growth and induces apoptosis. However, mechanism Hcy‐induced programmed cell death in endothelial cells is largely unknown. We hypothesize that Hcy intracellular reactive oxygen species (ROS) production leads to loss transmembrane mitochondrial potential (Δψ m ) accompanied by release cytochrome‐ c from mitochondria. Cytochrome‐ contributes caspase activation, such as caspase‐9, caspase‐6, caspase‐3, which results degradation...
It has been suggested that neuroplasticity-promoting neuromodulation can restore sensory-motor pathways after spinal cord injury (SCI), reactivating the dormant locomotor neuronal circuitry. We introduce a neuro-rehabilitative approach leverages training with multi-segmental transcutaneous electrical stimulation (scTS). hypothesized scTS neuromodulates networks, complementing neuroplastic effects of training, result in functional progression toward recovery locomotion. conducted case-study...
Extracellular matrix (ECM) turnover is regulated by metalloproteinases (MMPs) and plays an important role in cardiac remodeling. Previous studies from our lab demonstrated increase gelatinolytic-MMP-2 -9 activities endocardial tissue ischemic cardiomyopathic (ICM) idiopathic dilated (DCM) hearts. The signaling mechanism responsible for the left ventricular (LV) remodeling, however, unclear. Administration of specific inhibitor metalloproteinase (CIMP) prevented activation MMP-2 ailing to...
Chronic hyperhomocysteinemia (HHcy) is an important factor in development of arterial hypertension. HHcy associated with activation matrix metalloproteinases (MMPs); however, it unclear whether HHcy-dependent extracellular (ECM) accumulation plays a role hypertrophy and We tested the hypothesis that mechanism hypertension involves dysfunction response to ECM between endothelial smooth muscle cells subsequent endothelium-myocyte (E-M) uncoupling. To decrease plasma Hcy, dietary...
Elevated oxidative stress has been characterized in numerous disorders including systemic hypertension, arterial stiffness, left ventricular hypertrophy (LVH) and heart failure.The peroxisome proliferator activated receptor gamma (PPARγ) ameliorates LVH.To test the hypothesis that PPARγ decreased LVH cardiac fibrosis chronic pressure overload, part, by increasing SOD, eNOS elastin decreasing NOX4, MMP collagen synthesis degradation, overload analogous to hypertension was created C57BL/6J...
Unstable blood pressure after spinal cord injury (SCI) is not routinely examined but rather predicted by level and completeness of (i.e., American Spinal Injury Association Impairment Scale AIS classification). Our aim was to investigate hemodynamic response a sit-up test in large cohort individuals with chronic SCI better understand cardiovascular function this population. Continuous ECG were recorded from (n = 159) non-injured 48). We found orthostatic hypotension occurred within each...
Accumulation of oxidized extracellular matrix between endothelium and muscle is an important risk factor in the endothelium-myocytes uncoupling congestive heart failure. Although ventricular remodeling accompanied by increased metalloproteinase (MMP)-9 activity, it unclear whether MMP-9 plays a role endothelial apoptosis chronic volume overload We tested hypothesis that, overload, myocardial dysfunction involves endocardial (EE) response to activation, accumulation, uncoupling. Arteriovenous...
OPINION article Front. Hum. Neurosci., 13 January 2021 | https://doi.org/10.3389/fnhum.2020.622533