A5064463784- Mental Health Research Topics
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Infant Health and Development
- Memory and Neural Mechanisms
- Mental Health Treatment and Access
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Tryptophan and brain disorders
- Psychosomatic Disorders and Their Treatments
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Treatment of Major Depression
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Evolutionary Psychology and Human Behavior
- Attachment and Relationship Dynamics
University College London
2011
University of Oxford
2008-2010
Warneford Hospital
2008-2009
Acute administration of an antidepressant increases positive affective processing in healthy volunteers, effect that may be relevant to the therapeutic actions these medications. The authors investigated whether this is apparent depressed patients early treatment, prior changes mood and symptoms.In a double-blind, placebo-controlled, between-groups randomized design, examined single 4-mg dose norepinephrine reuptake inhibitor reboxetine on emotional processing. Thirty-three were recruited...
Abstract Animal studies have shown the role of oxytocin in affiliation and attachment, recent evidence suggests that is also involved human models approach behaviour, possibly by modulating processing emotionally valenced stimuli. Although administration has been reported to decrease neural responses facial emotional information, effects on a wider range behavioural measures be sensitive antidepressant manipulation not examined. The aim this study was investigate whether intranasally...
The neurokinin-1 (NK(1)) receptor antagonist, aprepitant, showed activity in several animal models of depression; however, its efficacy clinical trials was disappointing. There is little knowledge the role NK(1) receptors human emotional behaviour to help explain this discrepancy. aim current study assess effects a single oral dose aprepitant (125 mg) on processing sensitive conventional antidepressant drug administration 38 healthy volunteers, randomly allocated receive or placebo between...