A5007863168- Pancreatic function and diabetes
- Prostate Cancer Diagnosis and Treatment
- Diabetes and associated disorders
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- interferon and immune responses
- RNA modifications and cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- MRI in cancer diagnosis
Institut de Biologie Valrose
2018-2022
Bellvitge University Hospital
2022
Institut Català d'Oncologia
2022
Institut d'Investigació Biomédica de Bellvitge
2022
Inserm
2018-2022
Université Côte d'Azur
2018-2022
Centre National de la Recherche Scientifique
2018-2022
Breast cancer risk for carriers of BRCA1 pathological variants is modified by genetic factors. Genetic variation in HMMR may contribute to this effect. However, the impact modifiers on biology remains undetermined and biological basis increased poorly understood. Here, we depict an interplay molecular, cellular, tissue microenvironment alterations that increase BRCA1-associated breast risk. Analysis genome-wide association results suggests diverse processes, including links BRCA1-HMMR...
Three-dimensional multiparametric ultrasound (3D mpUS) shows promise for accurately diagnosing prostate cancer. However, its technical complexity presents usability challenges. Human Factor Engineering (HFE) studies the interaction between devices and users, by reducing human error, increasing productivity, enhancing safety. The objective is to develop a training program 3D mpUS using HFE (NCT04605276). This study employs human-centered design approach, principle of HFE, with formative...
Type 1 diabetes results from the autoimmune-mediated loss of insulin-producing beta-cells. Accordingly, important research efforts aim at regenerating these lost beta-cells by converting pre-existing endogenous cells. Following up on previous demonstrating conversion pancreatic somatostatin delta-cells into beta-like cells upon Pax4 misexpression and acknowledging that somatostatin-expressing are highly represented in gastrointestinal tract, one could wonder whether this -mediated also occur...
Background: Although several approaches have revealed much about individual factors that regulate pancreatic development, we yet to fully understand their complicated interplay during pancreas morphogenesis. Gfi1 is transcription factor specifically expressed in acinar cells, whose role cells fate identity and specification still elusive. Methods: In order gain further insight into the function of this pancreas, generated animals deficient for pancreas. conditional knockout were...