Paramasamy Gunasekaran

ORCID: 0000-0002-8078-2123
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About
Contact & Profiles
Research Areas
  • Enzyme Production and Characterization
  • Biofuel production and bioconversion
  • Genomics and Phylogenetic Studies
  • Microbial Metabolites in Food Biotechnology
  • Bacteriophages and microbial interactions
  • Brucella: diagnosis, epidemiology, treatment
  • Bacterial Genetics and Biotechnology
  • Microbial Metabolic Engineering and Bioproduction
  • Enzyme Catalysis and Immobilization
  • Plant-Microbe Interactions and Immunity
  • Antimicrobial Peptides and Activities
  • Protein Hydrolysis and Bioactive Peptides
  • Probiotics and Fermented Foods
  • RNA and protein synthesis mechanisms
  • Microbial Community Ecology and Physiology
  • Enzyme Structure and Function
  • Legume Nitrogen Fixing Symbiosis
  • Bacterial biofilms and quorum sensing
  • Salmonella and Campylobacter epidemiology
  • Gut microbiota and health
  • Plant Pathogenic Bacteria Studies
  • Biochemical and Structural Characterization
  • Studies on Chitinases and Chitosanases
  • Escherichia coli research studies
  • Environmental DNA in Biodiversity Studies

Madurai Kamaraj University
2009-2022

Jagran Lakecity University
2018-2022

Barkatullah University
2018-2022

Madhya Pradesh Bhoj Open University
2017-2020

Vellore Institute of Technology University
2016-2018

Thiruvalluvar University
2013-2016

Madurai Medical College
2015

GTx (United States)
2011

Wellcome Sanger Institute
2011

Weizmann Institute of Science
2000

Antimicrobial peptides are diverse group of biologically active molecules with multidimensional properties. In recent past, a wide variety AMPs structures have been reported from different sources such as plants, animals, mammals, and microorganisms. The presence unusual amino acids structural motifs in confers unique properties to the peptide that attribute for their specific mode action. ability these act multifunctional effector signalling molecule, immune modulators, mitogen, antitumor,...

10.1155/2013/675391 article EN cc-by International Journal of Peptides 2013-06-26

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. An expanding body evidence supports role human microbiome in establishment CVDs and, this has gained much attention recently. This work was aimed to study circulating CVD patients and healthy subjects. The levels cell free DNA (circDNA) higher (n = 80) than controls 40). More specifically, relative bacterial ratio 16S rRNA/β-globin gene copy numbers were circulation individuals. In addition, we found a microbial...

10.1371/journal.pone.0105221 article EN cc-by PLoS ONE 2014-08-18

We have developed a number of broad-host-range plasmids that allow the expression Escherichia coli lac operon from any cloned promoter, and creation 'in phase' fusions between lacZ other genes. In second series constructions, E. gal has been into vector plasmid carrying both genes is described. These transferred Pseudomonas aeruginosa Zymomonas mobilis their effects on utilisation lactose galactose investigated.

10.1111/j.1574-6968.1992.tb05378.x article EN FEMS Microbiology Letters 1992-08-01

Abstract Metagenomic DNA isolated from goat skin surface was used to construct plasmid library in Escherichia coli DH10B. Recombinant clones were screened for functional protease activity on skim milk agar plates. Upon screening 70,000 clones, a clone carrying recombinant pSP1 exhibited activity. In vitro transposon mutagenesis and sequencing of the insert this revealed an ORF 1890 bp encoding protein with 630 amino acids which showed significant sequence homology peptidase S8 S53 subtilisin...

10.1186/2191-0855-1-3 article EN cc-by AMB Express 2011-03-28

Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant pathogen and one of the leading causes nosocomial infection worldwide. Probiotic bacteria play significant role in preventive or therapeutic interventions gastrointestinal infections human as well animals. In this study, we have investigated adhesion property probiotic strain Lactobacillus fermentum MTCC 8711 its ability to prevent MRSA colon adenocarcinoma cells, Caco-2. We shown that L. could efficiently adhere...

10.3389/fmicb.2018.00411 article EN cc-by Frontiers in Microbiology 2018-03-08

Catalogue of Somatic Mutations in Cancer (COSMIC) (http://www.sanger.ac.uk/cosmic) is a publicly available resource providing information on somatic mutations implicated human cancer. Release v51 (January 2011) includes data from just over 19 000 genes, 161 787 coding and 5573 gene fusions, described more than 577 tumour samples. COSMICMart (COSMIC BioMart) provides flexible way to mine these combine with other biological relevant sets. This article describes the COSMIC along examples how...

10.1093/database/bar018 article EN cc-by Database 2011-05-23

With the advent of Green Revolution, there has been a quantum leap in use synthetic herbicides and pesticides throughout world to sustain high yielding crop varieties. Continuous these chemicals leads loss soil fertility organisms. To explore effect exposure commercial herbicide (Butachlor) on life history parameters (biomass, clitellum development, cocoon production) histological changes earthworm Eisenia fetida over 60 days, dried cow dung was contaminated with 0.2575 mg<mml:math...

10.1155/2010/850758 article EN cc-by Applied and Environmental Soil Science 2010-01-01

Abstract Enterobacter cloacae GS1 was isolated by in‐planta enrichment of a rice rhizoplane bacterial community. It displayed strong seed adherence ability (2.5 × 10 5 cfu/seed) and colonized roots reaching up to 1.65 9 cfu/g fresh root weight in gnotobiotic colonization system. E. motile, able solubilize tricalcium phosphate, produced indole acetic acid like substances (15 μg/ml). As an introduced bioinoculant non‐sterile soil, significantly improved the weight, length, shoot nitrogen...

10.1002/jobm.201000342 article EN Journal of Basic Microbiology 2011-06-09

Bacterial, small RNAs were once regarded as potent regulators of gene expression and are now being considered essential for their diversified roles. Many reported to have a wide array regulatory functions, ranging from environmental sensing pathogenesis. Traditionally, noncoding transcripts rarely detected by means genetic screens. However, the availability approximately 2200 prokaryotic genome sequences in public databases facilitates efficient computational search those molecules, followed...

10.4137/bbi.s11213 article EN cc-by-nc Bioinformatics and Biology Insights 2013-01-01
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