A5081597508- Wound Healing and Treatments
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Cancer-related Molecular Pathways
- Engineering Technology and Methodologies
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Bone Tissue Engineering Materials
- Carcinogens and Genotoxicity Assessment
- Reconstructive Surgery and Microvascular Techniques
- Oral and Maxillofacial Pathology
- Medical and Biological Ozone Research
- Hydrogels: synthesis, properties, applications
- Bacteriophages and microbial interactions
- Protein purification and stability
- Tissue Engineering and Regenerative Medicine
- Nuclear Materials and Properties
- Silk-based biomaterials and applications
- Glycosylation and Glycoproteins Research
- Bone and Dental Protein Studies
- Ubiquitin and proteasome pathways
- Nuclear Physics and Applications
Kurchatov Institute
2014-2022
State Research Center for Applied Microbiology and Biotechnology
2018
Human Stem Cells Institute PJSC (Russia)
2014
Russian Academy of Sciences
2012
Nuclear Safety Institute
2012
Voronezh State University
2012
In search for a new pro-angiogenic scaffold material suitable skin bioengineering and grafting therapy, we have fabricated number of composite sodium alginate (AG)–fibrinogen (FG) sponge scaffolds using the freeze-drying approach. Thrombin was added to drive FG/fibrin conversion, while ε-aminocapronic acid (εAc) used as antifibrinolytic component. The slow rates biodegradation were achieved by Ca2+ Mg2+ cations cross-linking agents. novel thrombin-modified AG–FG with highly interconnected...
Biocompatible ceramic fillers are capable of sustaining bone formation in the proper environment. The major drawback these scaffolding materials is absence osteoinductivity. To overcome this limitation, bioengineered scaffolds combine osteoconductive components (biomaterials) with osteogenic features such as cells and growth factors. marrow mesenchymal stromal (BMMSCs) β-tricalcium phosphate (β-TCP) well-known characterized regard. present study was conducted to compare properties novel...
The skin is a combination of two different types tissue-epithelial and connective (mesenchymal). outer protective layer the skin, epidermis, consists multiple layers keratinocytes residing on basement membrane that separates them from underlying dermis, which well-vascularized fibrous extracellular matrix seeded mainly by fibroblasts mesenchymal stromal cells. These features suggest development fibroblast-friendly porous scaffold covered with flat dense sheath mimicking membrane, sufficient...
Protons are the relatively heavy charged particles and therefore can be accelerated to any energy, permitting long distance penetration in human body practically without loss of dose-rate. In addition, due low side scatter use these permits obtaining better dose distribution between tumor surrounding healthy tissues comparison with traditional sources ionizing radiations. The limited clinical study proton radiotherapy was initiated early 1950th USA shortly afterwards Sweden, at end 1960th...
This article is focused on comparative analysis of osteogenic potential multipotent mesenchymal stromal cells (MMSC) derived from different sources: gingival mucosa and bone marrow. MMSC immunophenotype, proliferation differentiation capacity were investigated in this work. Ability adhesion to p-tricalcium phosphate was also examined. Osteoinductive tissue-engineered grafts (MMSCs + phosphate) shown experiments carried out NOD-SCID mice heterotopic formation test. Results research...
The published data regarding radiation therapy of tumors treatment with ultrahigh dose rate has been analyzed. In 2014, the authors, among whom most mentioned are Vincent Favaudon and MarieCatherine Vozenin, named it flash effect. Note, however, that a member our laboratory, S.V. Kozin in collaboration ITEP researchers, back 1984, having studied reaction graft mice skin after proton irradiation ordinary rates, concluded that: ‘... an increase to ultrahigh, without significantly changing...
For optimization of conditions skin and gingival mucosa derived human fibroblasts obtainment cultivation in this work we performed comparative analysis 11 fetal bovine serums (from different manufacturers) autologous serum. Our included also comparison 3 serum-free media 4 serum-reduced media. Evaluation criterion at the step primary cell culture was colony-formation efficiency during subsequent - population doubling time. Results revealed that ability skin-derived to form colonies could...
Abstract The work is aimed at the development of biodegradable porous frame materials that combine high biocompatibility and possess pro-angiogenic properties, is, ability to ensure active germination vessels recipient tissue and, possibly, formation de novo vascular bed. Approaches have been developed create a two-layer matrix structure based on biopolymers - sodium alginate collagen. provides functions skin protective (from external environmental factors) regenerative restoration...
Irradiation of the tumor through ridge filters in order to reduce damage normal tissues while maintaining same neoplastic tissue as with uniform field is used for many decades. In recent years, a positive effect has been demonstrated using synchrotron radiation and beams accelerated protons fields diminished 25-100 micrometers distances between them. Less skin achieved required level large neoplasms eradication case X-ray gamma irradiation can be partially explained by features physical...
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