A5026167684- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Dental materials and restorations
- Endodontics and Root Canal Treatments
- Facial Trauma and Fracture Management
- Additive Manufacturing and 3D Printing Technologies
- Calcium Carbonate Crystallization and Inhibition
- Chemical Synthesis and Characterization
- Advanced materials and composites
- biodegradable polymer synthesis and properties
- Metal and Thin Film Mechanics
- Periodontal Regeneration and Treatments
- Luminescence Properties of Advanced Materials
- Engineering Technology and Methodologies
- Titanium Alloys Microstructure and Properties
- Electrospun Nanofibers in Biomedical Applications
- Pigment Synthesis and Properties
- Magnesium Oxide Properties and Applications
- X-ray Diffraction in Crystallography
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Radioactive element chemistry and processing
- Material Properties and Applications
Baikov Institute of Metallurgy and Materials Science
2015-2024
Russian Academy of Sciences
2011-2020
Federal Scientific Research Centre Crystallography and Photonics
2016-2020
Institute of Metallurgy and Materials Science
2015-2020
Institute on Laser and Information Technologies
2015-2019
Institute of Metallurgy
2014-2017
P.A. Hertzen Moscow Oncology Research Institute
2017
Ministry of Health of the Russian Federation
2017
Pirogov Russian National Research Medical University
2017
Warsaw University of Technology
2016
Structured Abstract Authors – Mastrogiacomo M, Muraglia A, Komlev V, Peyrin F, Rustichelli Crovace Cancedda R Background Large bone defects still represent a major problem in orthopedics. Traditional bone‐repair treatments can be divided into two groups: the transport (Ilizarov technology) and graft transplant (autologous or allogeneic grafts). Thus far, none of these strategies have proven to always resolving. As an alternative, tissue engineering approach has been proposed where osteogenic...
Bioceramics are used to treat bone defects but in general do not induce formation of new bone, which is essential for regeneration process. Many aspects related bioceramics synthesis, properties and biological response that still unknown and, there a great need further development. In the most recent research efforts were aimed on creation materials from precursors apatite humans. One possible precursor octacalcium phosphate (OCP), believed only exhibit osteoconductivity possess...
Scaffolding is the conceptual framework of conventional tissue engineering. Over past decade, scaffold-free approaches as a potential alternative to classic scaffold-based methods have emerged, and magnetic levitational engineering (magnetic force-based [Mag-TE]) type this novel strategy. However, Mag-TE often based on use potentially toxic nanoparticles. Scaffold-free label-free bioassembly do not employ nanoparticles thus, toxicity can be avoided. In short review, we describe foundation...
In search for a new pro-angiogenic scaffold material suitable skin bioengineering and grafting therapy, we have fabricated number of composite sodium alginate (AG)–fibrinogen (FG) sponge scaffolds using the freeze-drying approach. Thrombin was added to drive FG/fibrin conversion, while ε-aminocapronic acid (εAc) used as antifibrinolytic component. The slow rates biodegradation were achieved by Ca2+ Mg2+ cations cross-linking agents. novel thrombin-modified AG–FG with highly interconnected...
Abstract Resorbable ceramic scaffolds based on Silicon stabilized tricalcium phosphate (Si‐TCP) were seeded with bone marrow stromal cells (BMSC) and ectopically implanted for 2, 4, 6 months in immunodeficient mice. Qualitative quantitative evaluation of the scaffold material was performed by X‐ray synchrotron radiation computed microtomography (microCT) a spatial resolution lower than 5 µm. Unique to these experiments that microCT data first collected before implantation then same after...
Three types of ceramic scaffolds with different composition and structure [namely synthetic 100% hydroxyapatite (HA; Engipore), calcium phosphate multiphase biomaterial containing 67% silicon stabilized tricalcium (Si-TCP; Skelite™) natural bone mineral derived (Bio-oss®)] were seeded mesenchymal stem cells (MSC) ectopically implanted for 8 16 weeks in immunodeficient mice.X-ray synchrotron radiation microtomography was used to derive 3D structural information on the same both before after...
Calcium phosphate bone cements (CPCs) with antibacterial properties are demanded for clinical applications. In this study, we demonstrated the use of a relatively simple processing route based on preparation silver-doped CPCs (CPCs-Ag) through solid dispersed active powder phase. Real-time monitoring structural transformations and kinetics several CPCs-Ag formulations (Ag = 0 wt %, 0.6 % 1.0 %) was performed by Energy Dispersive X-ray Diffraction technique. The partial conversion...
Biocompatible calcium phosphate ceramic grafts are able of supporting new bone formation in appropriate environment. The major limitation these materials usage for medical implants is the absence accessible methods their patient-specific fabrication. 3D printing methodology an excellent approach to overcome effective and fast fabrication individual complex substitutes. Here, we proposed a relatively simple route octacalcium phosphates (OCP) complexly shaped structures by combination inkjet...
Al-substituted hydroxyapatite (Al-HA) powders with apatite structure and particle size of 30–70 nm were obtained via precipitation method. The effect Al content on specific surface area morphology was studied, a formation highly anisotropic phase due to doping observed. influence heat treatment in 300–1400 °C range the composition, lattice parameters, Fourier-transform infrared spectroscopy (FTIR) spectra mass loss investigated. Introduction (HA) 0.5–1.0 mol.% resulted improvement thermal...
Mesoporous hydroxyapatite (HA) and iron(III)-doped HA (Fe-HA) are attractive materials for biomedical, catalytic, environmental applications. In the present study, nanopowders of Fe-HA with a specific surface area up to 194.5 m2/g were synthesized by simple precipitation route using iron oxalate as source Fe3+ cations. The influence amount on phase composition, powders morphology, Brunauer–Emmett–Teller (BET) (S), pore size distribution investigated, well electron paramagnetic resonance...
Mesoporous iron-doped hydroxyapatite (HA) powders with a surface area up to 141 m2/g were synthesized and characterized by variety of analytical computational approaches, including X-ray diffraction (XRD) fluorescence spectroscopy (XRF), atomic emission spectrometry inductively coupled plasma (AES-ICP), Fourier transform infrared absorption (FTIR), nitrogen adsorption–desorption (BET), scanning transmission electron microscopy (SEM TEM), paramagnetic resonance (EPR), density functional...
Bone grafting and reconstruction are still challenging in clinical practice because of the limitations bone autografts drawbacks currently approved substitutes. We thus developed a gene-activated substitute based on octacalcium phosphate naked plasmid DNA carrying vascular endothelial growth factor gene. This advanced combined therapy medicinal product had no cytotoxic effects vitro , slightly decreased marrow mesenchymal stromal cell (MSC) doubling time, was characterized by prolonged level...