A5052952521- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Dental Implant Techniques and Outcomes
- Medical and Biological Sciences
- COVID-19 Clinical Research Studies
- Periodontal Regeneration and Treatments
- biodegradable polymer synthesis and properties
- Long-Term Effects of COVID-19
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Rheumatoid Arthritis Research and Therapies
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Bone fractures and treatments
- Polymer Synthesis and Characterization
- Orthopedic Infections and Treatments
- Biochemical effects in animals
- Graphene and Nanomaterials Applications
- Venous Thromboembolism Diagnosis and Management
- Medical Imaging and Analysis
- Dermatological and COVID-19 studies
- Spine and Intervertebral Disc Pathology
- Dental Radiography and Imaging
Peoples' Friendship University of Russia
2018-2025
Research Institute of Human Morphology
2009-2024
Central Scientific Research Institute of Traumatology and Orthopedics
2017-2024
Ministry of Health of the Russian Federation
2020-2023
V.A. Negovsky Scientific Research Institute of General Reanimatology
2021-2022
City Clinical Hospital
2020-2021
City Clinical Hospital No. 2
2018
National Medical Research Center of Dentistry and Maxillofacial Surgery
2018
Russian Scientific Center of Surgery
2018
Privolzhsky Research Medical University
2018
We report a one-pot plasma electrolytic oxidation (PEO) strategy for forming multi-element oxide layer on the titanium surface using complex electrolytes containing Na2HPO4, Ca(OH)2, (NH2)2CO, Na2SiO3, CuSO4, and KOH compounds. For even better bone implant ingrowth, PEO coatings were additionally loaded with morphogenetic protein-2 (BMP-2). The samples tested in vivo mouse craniotomy model. Tests bactericidal fungicidal activity carried out clinically isolated multi-drug-resistant...
BACKGROUND: Given the increasing number of patients with alveolar bone atrophy and jaw defects following trauma, relevance developing new materials osteoinductive properties remains high, highlighting importance research in field tissue engineering. AIMS: To investigate potential a novel substitution material based on poly-3-hydroxybutyrate enriched simvastatin an vivo experiment sheep. MATERIALS AND METHODS: A single-center, prospective, comparative study was conducted involving 24 healthy...
The increased plasma levels of von Willebrand factor (VWF) in patients with COVID-19 was reported many studies, and its correlation disease severity mortality suggest important role the pathogenesis thrombosis COVID-19. We performed histological immunohistochemical studies lungs 29 who died from found a significant increase intensity reaction for VWF pulmonary vascular endothelium when duration more than 10 days. In had thrombotic complications, immunostaining significantly intense...
Lymphopenia is a frequent hematological manifestation, associated with severe course of COVID-19, an insufficiently understood pathogenesis. We present molecular genetic immunohistochemical, and electron microscopic data on SARS-CoV-2 dissemination viral load (VL) in lungs, mediastinum lymph nodes, the spleen 36 patients who died from COVID-19. <1 × 109/L was observed 23 (63.8%) patients. In 12 cases (33%) found lung tissues only median VL 239 copies (range 18-1952) cDNA per 100 ABL1....
This pilot study examined the long-term structural changes in osteochondral unit of 20 patients with knee osteoarthritis (KOA) who underwent high tibial osteotomy (HTO) and received post-treatment either platelet-rich plasma (PRP) or stromal vascular fraction (SVF). Ten were injected autologous PRP (PRP subgroup), while another ten SVF (SVF subgroup) six weeks after surgery monitored for 18 months. Histological samples bone cartilage (2 mm diameter 2 cm long) taken from femoral sites during...
Millions of people worldwide suffer from musculoskeletal damage, thus using the largest proportion rehabilitation services. The limited self-regenerative capacity bone and cartilage tissues necessitates development functional biomaterials. Magnetoactive materials are a promising solution due to clinical safety deep tissue penetration magnetic fields (MFs) without attenuation heating. Herein, electrospun microfibrous scaffolds were developed based on piezoelectric poly(3-hydroxybutyrate)...
The international recommendations «Treat to target» (T2T) underline the greatest importance of treatment strategy for success treating rheumatoid arthritis (RA). Evaluation efficiency this approach obviously requires special strategic studies with an adaptive design, which substantially differ from classical randomized clinical trials and are much closer practice. To date, there only single publications on practical application T2T recommendations, is a problem in choice effectiveness...
COVID-19-related thrombosis affects the venous and arterial systems. Data from 156 autopsies of COVID-19 patients were retrospectively analyzed to investigate pattern thrombotic complications factors associated with pulmonary artery thromboembolism. Thrombotic observed in a significant proportion (
Multi-organ failure is one of the common causes fatal outcome in COVID-19 patients. However, pathogenetic association SARS-CoV-2 viral load (VL) level with dysfunctions lungs, liver, kidneys, heart, spleen and brain, as well risk death patients remains poorly understood. VL lymph nodes have been measured by RT qPCR using following formula: NSARS-CoV-2/NABL1 × 100. Dissemination 30.5% cases was mono-organ, 63.9% cases, it multi-organ. The average exudative phase diffuse alveolar damage (DAD)...
The aim of the investigation was to develop a technology manufacturing bone implants based on hybrid polymer construction composed poly(3-hydroxybutyrate) and sodium alginate for guided regeneration using 3D printing method.Materials Methods.Complex shaped were manufactured by method two-stage leaching mold obtained printing.The appearance, morphology structure scaffolds analyzed means scanning electron microscopy.Biocompatibility in vivo determined histology data implantation as...
In 2020 the world faced pandemic of COVID-19 severe acute respiratory syndrome caused by a new type coronavirus named SARS-CoV-2. To stop spread disease, it is crucial to create molecular tools allowing investigation, diagnoses and treatment COVID-19. One such are monoclonal antibodies (mAbs). this study we describe development hybridoma cells that can produce mouse mAbs against receptor binding domain SARS-CoV-2 spike (S) protein. These able specifically detect native denatured S proteins...
The role of metallic nano- and microparticles in the development inflammation has not yet been investigated. Soft tissue biopsy specimens bone bed taken during surgical revisions, as well supernatants obtained from surface orthopedic structures dental implants (control), were examined. Investigations performed using X-ray microtomography, fluorescence analysis, scanning electron microscopy. Histological studies tissues performed. Nanoscale microscale particles identified participants...
Despite the enormous interest in COVID-19, there is no clear understanding of mechanisms underlying neurological symptoms COVID-19. Microglia have been hypothesized to be a potential mediator manifestations associated with In most existing studies date, morphological changes internal organs, including brain, are considered isolation from clinical data and defined as consequence We performed histological immunohistochemical (IHC) brain autopsy materials 18 patients who had died evaluated...
The objective of the present study was to elucidate morphological and morphometric characteristics human thyroid cartilage during different periods life. cartilages were harvested from 70 cadavers subjects masculine gender who had died at age 1 93 years non-violent causes neither injuries nor signs pathological changes in neck organs. microscopic studies carried out using standard methods for staining preparations with hematoxylin eosin. following parameters evaluated: area cartilaginous...
The aim of the study was to identify pathomorphology brain damage in patients who died COVID-19. Material and methods . Autopsy reports autopsy material 17 deceased with pre-mortem confirmed COVID-19 infection were analyzed. Fatal cases which COVID19 major cause death included study. Five people diagnosed cerebral infarction. Organ samples taken for histological examination during autopsy. Sections stained hematoxylin eosin by Nissl assess histopathology. To vascular basal membranes PAS...
Scaffold biocompatibility remains an urgent problem in tissue engineering. An especially interesting is guided cell intergrowth and sprouting using a porous scaffold with special design. Two types of structures were obtained from poly(3-hydroxybutyrate) (PHB) salt leaching technique. In flat scaffolds (scaffold-1), one side was more (pore size 100–300 μm), while the other smoother 10–50 μm). Such are suitable for vitro cultivation rat mesenchymal stem cells 3T3 fibroblasts, and, upon...