A5057662972- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Rheumatoid Arthritis Research and Therapies
- Liver Diseases and Immunity
- Renal Diseases and Glomerulopathies
- Hepatitis C virus research
- Salivary Gland Disorders and Functions
- Diabetes and associated disorders
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Sclerosis and Related Diseases
- Musculoskeletal Disorders and Rehabilitation
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Galectins and Cancer Biology
- Lymphoma Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Otitis Media and Relapsing Polychondritis
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders
- Pneumonia and Respiratory Infections
- Adrenal Hormones and Disorders
- Autoimmune and Inflammatory Disorders Research
Sismanoglio General Hospital
2019-2024
National and Kapodistrian University of Athens
2019-2021
Center for Rheumatology
2019
University of Ioannina
2008
Evidence on comorbidity prevalence in antiphospholipid syndrome (APS) and its difference from high burden rheumatic diseases is limited. Herein, we compare multiple comorbidities between APS RA.A total of 326 patients the Greek registry [237 women, mean age 48.7 (13.4) years, 161 primary (PAPS), 165 SLE-APS] were age/sex matched (1:2 ratio) with 652 a multicentre RA cohort 3115 patients. Prevalence cardiovascular (CV) risk factors, stroke, coronary artery disease (CAD), osteoporosis,...
Abstract Objectives There are limited data regarding health-related quality of life (HRQoL) in patients with ANCA-associated vasculitides (AAVs). We aimed to evaluate the HRQoL AAVs and compare it another chronic inflammatory disease like RA healthy controls (HC). Methods This was a multicentre, cross-sectional study recruited from three tertiary rheumatology clinics. assessed Short Form 36 Health Survey, which included physical mental component summary scores (PCS MCS). Data 1007 HC served...
Abstract Objectives There are limited real-life data regarding the efficacy and safety of rituximab (RTX) as a remission maintenance agent in microscopic polyangiitis (MPA) granulomatosis-with-polyangiitis (GPA). We aimed to estimate incidence risk factors for relapses, well serious adverse events (SAEs) MPA/GPA patients during RTX maintenance. Methods A retrospective cohort newly diagnosed/relapsing GPA/MPA who received (≥1 cycle, ≥6 months follow-up) following complete (BVAS version-3 = 0...
Patients with rheumatoid arthritis (RA) are at increased risk for serious infections. Pneumococcal vaccination is among the most important preventive measures, however, vaccine uptake suboptimal. We explored rate and factors associated pneumococcal in a contemporary RA cohort. Multi-center, prospective, cohort study Greece. Patient disease characteristics influenza vaccinations were documented baseline 3 years later. One thousand six hundred ninety-seven patients included 34.5% had already...
Abstract Background Serious infections (SI) are common in patients with ANCA-associated vasculitides (AAV) like granulomatosis polyangiitis (GPA) and microscopic (MPA). Real-life data regarding their incidence predisposing factors—after the introduction of B cell depleting agents—are limited while quantifying risk per treatment modality year disease missing. Here, we aim to describe details factors for SI a contemporary AAV cohort. Methods Multicenter, observational, retrospective study...
Predicting serious infections (SI) in patients with rheumatoid arthritis (RA) is crucial for the implementation of appropriate preventive measures. Here we aimed to identify risk factors SI and validate RA Observation Biologic Therapy (RABBIT) score real-life settings.A multi-centre, prospective, cohort study Greece. Demographics, disease characteristics, treatments comorbidities were documented at first evaluation one year later. The incidence was recorded compared expected rate using...
<h3>Objective</h3> To decide on the optimal positioning of combination therapies in lupus nephritis (LN), we aimed to determine renal response rates with standard-of-care (SoC) treatment at 3, 6 and 12 months according EULAR/ERA- EDTA targets real-life clinical practice. <h3>Methods</h3> 135 patients recent LN (2015- present) were included a retrospective/prospective cohort study. Demographic, clinical, laboratory data, as well baseline every 3 collected. Response first year EULAR/ERA-EDTA,...
Deregulation of glucocorticoid (GC) secretion could be associated with rheumatoid arthritis (RA). The GC receptor (GR) has two isoforms. In the present study, we explored role GR-alpha polymorphisms rs33388, rs33389, and Bcl I, GR-beta variant rs6198 in RA susceptibility.One hundred thirty-six patients 148 ethnic matching controls were studied. Polymorphisms rs33388 I genotyped by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), variants rs33389 single-strand...
Background: Primary Sjogren’s syndrome (SS) is an autoimmune disease with a strong predilection for lymphoma development, earlier onset being postulated as independent risk factor this complication. Variations of the Leukocyte immunoglobulin-like receptor A3(LILRA3) gene have been previously shown to increase susceptibility both SS and non-Hodgkin B-cell (B-NHL) in general population. We aimed investigate whether variations LILRA3 could predispose development context SS. Methods: Study...
Despite the recent advances in treatment, antineutrophil cytoplasmic antibody (ANCA) associated vasculitides (AAV) are among rheumatic diseases with highest morbidity and mortality. These outcomes affected by a variety of factors apart from disease itself, driven infections, cardiovascular drug toxicity. Even after induction remission, patients their treating physicians challenged frequent relapses, accrual chronic damage impaired quality life. Given rarity along heterogeneous spectrum,...
<h3>Background:</h3> Primary Sjögren's Syndrome (SS) is a systemic autoimmune disease, characterized by increased risk of non-Hodgkin's lymphoma development. A functional polymorphism the immunoreceptor LILRA3 (Leukocyte immunoglobulin-like receptor A3) has been recently identified as potential etiopathogenic factor for both pSS susceptibility and lymphomagenesis in general population. <h3>Objectives:</h3> The aim current study was to explore contribution primary SS related lymphomagenesis....
Objective To estimate real-life European Alliance of Associations for Rheumatology (EULAR)/European Renal Association (ERA)-European Dialysis and Transplantation (EDTA) response rates predictors no in patients with lupus nephritis (LN) managed conventional immunosuppressive therapies. Methods Ambidirectional cohort study new-onset LN (period 2014–to date). Response the first year were calculated, all treatment modifications recorded. Univariate multivariate regression analyses performed to...
Background ANCA associated vasculitides (AAVs) are rare, serious forms of vasculitides. There limited data regarding the quality life in patients with AAVs compared to other chronic inflammatory diseases. Objectives The purpose this study was compare between AAV and those a arthritis such as rheumatoid (RA). Methods Multicenter, cross-sectional RA followed three tertiary referral centers. Data from 1007 healthy controls served historic controls. 1 HRQoL assessed Short Form 36 Health Survey...
Background: Despite the increased incidence of influenza infection in rheumatoid arthritis (RA) patients, vaccination coverage has been shown to be suboptimal. Prospective data regarding current rate and predictors adherence RA patients are limited. Objectives: To calculate a real-life, prospective, longitudinal cohort. Methods: Data demographics, disease characteristics, treatments co-morbidities from multi-center, cohort Greek were collected at baseline ~ 3 years later. Disease patient...
<h3>Background</h3> The approval of two new drugs, belimumab and voclosporin, in lupus nephritis (LN) over the last years has raised questions regarding their place therapeutic algorithm LN. Their use initial regimens or refractory/relapsed disease depends on outcomes with current standard care (SoC) therapies. <h3>Objectives</h3> To calculate EULAR/ERA-EDTA renal response rates SoC therapies at 3, 6 12 months, as well successful tapering to recommended glucocorticoid months real-life...
Background: Comorbidities in rheumatic diseases (RDs) have been associated with increased morbidity and mortality. Evidence on prevalence of comorbidities antiphospholipid syndrome (APS) its difference from high comorbidity burden RDs is limited. Objectives: To compare the common between APS [primary (PAPS) Systemic lupus erythematosus (SLE)-APS] Rheumatoid arthritis (RA) patients. Methods: 326 patients Greek registry (237 women, mean age 48.7±13.4 years, 161 PAPS) were matched 1:2 for sex...
Raynaud's phenomenon (RP) is a condition characterised by distinct colour changes of the digits upon exposure to sympathomimetic conditions, such as cold temperature. It can be either primary or secondary, depending on whether it presents alone part an underlying disorder. One most common causes secondary RP are systemic autoimmune rheumatic diseases (SARDs), in which may precede onset other features many years. Thus, timely and accurate recognition great importance alters patient management...
Abstract Background Interstitial lung disease (ILD) is the most important pulmonary manifestation of connective tissue diseases (CTDs) since it associated with high morbidity and mortality. However, there uncertainty on what constitutes optimal treatment options from a variety competing interventions. The aim overview to summarize existing evidence effectiveness harm pharmacological therapies for adults CTD-ILD. Methods A literature search will be conducted in MEDLINE, Cochrane Database...