A5023351538- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Lipid metabolism and disorders
- Liver Diseases and Immunity
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Celiac Disease Research and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rheumatoid Arthritis Research and Therapies
- Otitis Media and Relapsing Polychondritis
- Cytokine Signaling Pathways and Interactions
- Peripheral Neuropathies and Disorders
- Inflammasome and immune disorders
- Renal Diseases and Glomerulopathies
- interferon and immune responses
- Complement system in diseases
- Inflammatory Myopathies and Dermatomyositis
- Phagocytosis and Immune Regulation
- Fungal Infections and Studies
- IgG4-Related and Inflammatory Diseases
- Genetic Syndromes and Imprinting
- Parvovirus B19 Infection Studies
- Pericarditis and Cardiac Tamponade
- Infectious Diseases and Mycology
National and Kapodistrian University of Athens
2019-2025
Academy of Athens
2023-2025
University Hospital of Ioannina
2020-2025
University of Ioannina
2020-2024
University General Hospital Attikon
2020-2023
Biomedical Research Foundation of the Academy of Athens
2019-2023
Center for Rheumatology
2020
Objectives Haematopoietic stem and progenitor cells (HSPCs) are multipotent giving rise to both myeloid lymphoid cell lineages. We reasoned that the aberrancies of immune in systemic lupus erythematosus (SLE) could be traced back HSPCs. Methods A global gene expression map bone marrow (BM)-derived HSPCs was completed by RNA sequencing followed pathway enrichment analysis. The cycle status apoptosis were assessed flow cytometry, while DNA damage via immunofluorescence. Results Transcriptomic...
Systemic lupus erythematosus with antiphospholipid syndrome (SLE-APS) represents a challenging SLE endotype whose molecular basis remains unknown.
Objective This study aimed to analyse the phenotype of systemic lupus erythematosus (SLE) at first presentation and during follow-up in a newly established SLE cohort based ‘Attikon’ University Hospital. The hospital combines primary, secondary tertiary care for region Western Attica, Greece. Methods comprised mixed prevalent incident 555 Caucasian patients diagnosed with according American College Rheumatology 1997 criteria and/or Systemic Lupus Erythematosus International Collaborating...
Objective Changes in the care of patients with SLE dictate a re-evaluation its natural history and risk factors for disease deterioration damage accrual. We sought to decipher predictive phenotype (‘transition’) initially presenting non-severe disease. Methods Patients from ‘Attikon’ cohort duration ≥1 year were included. Disease at diagnosis was categorised as mild, moderate or severe, based on British Isles Lupus Assessment Group manifestations physician judgement. ‘Transition’ severity...
The demyelinating syndromes of the central nervous system (CNS) that occur in context systemic lupus erythematosus (SLE) may represent a manifestation neuropsychiatric (NPSLE) or an overlap SLE and multiple sclerosis (MS). differential diagnosis between two entities has important clinical implications because therapeutic management differs.To characterize CNS large cohort as SLE-MS using multidisciplinary approach existing diagnostic (for MS) classification criteria SLE).Patients from...
Objective Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterised by variable treatment responses. We investigated the transcriptional landscape associated with response and resistance in SLE. Methods Blood was collected from 92 active patients SLE at baseline after 6 months (n=32 paired samples) of cyclophosphamide (n=40), rituximab (n=20), belimumab (n=23), mycophenolate mofetil (n=8) or azathioprine (n=1) subjected to RNA sequencing. The defined Lupus Low...
The management of neuropsychiatric systemic lupus erythematosus (NPSLE) remains challenging because clinical heterogeneity and the complexity pathophysiologic mechanisms involved. We sought to determine molecular signature NPSLE its endotypes towards novel biomarkers targeted therapies. Whole-blood RNA sequencing from 308 patients with (119 NPSLE, 189 non-NPSLE) 72-matched healthy controls (HCs) were performed. Supervised pathway enrichment analysis unsupervised weighted gene coexpression...
Patients with lupus nephritis (LN) are in urgent need for early diagnosis and therapeutic interventions targeting aberrant molecular pathways enriched affected kidneys.We used mRNA-sequencing effector (spleen) target (kidneys, brain) tissues from control mice at sequential time points, the blood 367 individuals (261 systemic erythematosus (SLE) patients 106 healthy individuals). Comparative cross-tissue cross-species analyses were performed. The human dataset was split into training...
Introduction Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) present with a complex phenotype and are associated high mortality multi-organ involvement. We sought to define the transcriptional landscape molecular endotypes of AAVs compare it systemic lupus erythematosus (SLE). Methods performed whole blood mRNA sequencing from 30 patients AAV (granulomatosis polyangiitis/GPA microscopic polyangiitis/MPA) combined functional enrichment network analysis for aberrant...
Interstitial pneumonia with autoimmune features (IPAF) refers to patients interstitial lung disease and not fulfilling the classification criteria for a specific connective tissue disease. We sought study characteristics, progression, response treatment complications of IPAF in 1-year follow-up period.Clinical laboratory findings, comorbidities, medications, pulmonary function tests (PFTs), chest HRCT during one-year period were documented each 39 enrolled IPAF.The mean age at time diagnosis...
<h3>Objective</h3> To decide on the optimal positioning of combination therapies in lupus nephritis (LN), we aimed to determine renal response rates with standard-of-care (SoC) treatment at 3, 6 and 12 months according EULAR/ERA- EDTA targets real-life clinical practice. <h3>Methods</h3> 135 patients recent LN (2015- present) were included a retrospective/prospective cohort study. Demographic, clinical, laboratory data, as well baseline every 3 collected. Response first year EULAR/ERA-EDTA,...
Objective To estimate real-life European Alliance of Associations for Rheumatology (EULAR)/European Renal Association (ERA)-European Dialysis and Transplantation (EDTA) response rates predictors no in patients with lupus nephritis (LN) managed conventional immunosuppressive therapies. Methods Ambidirectional cohort study new-onset LN (period 2014–to date). Response the first year were calculated, all treatment modifications recorded. Univariate multivariate regression analyses performed to...
CNS demyelinating syndromes occurring in the context of SLE may represent a manifestation neuropsychiatric lupus, or an overlap and multiple sclerosis (MS). We evaluated prospectively patients presenting with syndrome for clinical serological evidence characterized evolution their to defined disease.Patients not fulfilling criteria MS were rheumatology unit features followed longitudinally (enrolment period 2016-20). Clinical, laboratory neuroimaging data recorded at every visit, following...
<h3>Background:</h3> Systemic lupus erythematosus (SLE) with antiphospholipid syndrome (APS) represents one of the most challenging endotypes SLE, yet its distinctive molecular basis from non-APS SLE remains elusive. <h3>Objectives:</h3> To comprehensively profile blood transcriptome a large cohort patients who had APS or tested positive for aPL, to advance our understanding and introduce novel therapeutic interventions. <h3>Methods:</h3> We analyzed whole RNA-sequencing data 299 (108...
<h3>Background:</h3> Individuals with autoimmune rheumatic diseases (ARDs) that are receiving treatment rituximab (RTX) at higher risk of severe outcomes upon infection SARS-CoV-2 [1,2]. However, limited data exist regarding the efficacy Tixagevimab-Cilgavimab (Tix-Cil) prophylaxis in preventing COVID-19 such patients [3,4]. <h3>Objectives:</h3> To investigate and safety Tix-Cil RTX-treated ARD patients. <h3>Methods:</h3> Between October December 2022, was administered to 37 under chronic...
Background: Interstitial pneumonia with autoimmune features (IPAF) 1 describes a group of patients interstitial lung disease and who do not meet the classification criteria for specific connective tissue disease. Limited data regarding IPAF are available so far. Objectives: To identify epidemiological clinical characteristics to observe progression, response treatment frequency infections in 1-year follow-up period. Methods: Thirty-nine from ‘Attikon’ University Hospital Athens fulfilling...
<h3>Background</h3> SLE phenotype, severity and prognosis varies widely, while its course, pattern of cannot be predicted with confidence. <h3>Objectives</h3> We analyzed the phenotype patterns a cohort in Attica area Greece, based "Attikon" University Hospital, assessed whether these change over course disease. <h3>Methods</h3> Retrospective study 512 Caucasian patients fulfilling ACR 1997 and/or SLICC 2012 criteria. Data on clinical damage index (SDI) were recorded for each patient at time...
Background: The lack of pathognomonic features poses a considerable challenge in SLE diagnosis. time from symptom onset to diagnosis has been reported range two six years 1 . Objectives: To document the initial symptoms disease and lapse until its Methods: We examined 438 patients “Attikon” cohort 2 For diagnosis, we used classification criteria (ACR, SLICC, EULAR-ACR) or few cases clinical (n=32, 7.3%). Data were collected using patient interviews, in-person visits medical charts review....
Background: Systemic Lupus Erythematosus (SLE) can first present with severe or critical disease leading to hospitalization. Prompt recognition of the in hospitalized patients may lead early institution treatment and improve outcomes. We have recently developed a clinician-friendly algorithm for SLE diagnosis based on classical clinical serological features [SLE Risk Probability Index (SLERPI)] 1 . Objectives: To determine phenotype diagnosed during hospitalization, interval between...
<h3>Background</h3> Inflammatory arthritides (IA) can affect diverse body tissues beyond joints, including the heart [1,2]. Particularly in chronic inflammatory states, circulating immune mediators also induce central nervous system inflammation [3]. Nevertheless, little is currently known about consequences of cardiac on occurrence brain lesions these patients. <h3>Objectives</h3> We hypothesized that patients with IA and symptoms would show evidence lesions, presence be associated lesions....