The spread of the Internet Things (IoT) involving an uncountable number applications, combined with rise Machine Learning (ML), has enabled rapid growth pervasive and intelligent systems in a variety domains, including healthcare, environment, railway transportation Industry 4.0. While this opens up favorable scenarios, it also raises new challenges. huge amount data collected processed by ML applications requires efficient scalable solutions that contrast constrained capabilities IoT...

Agelastatin A, isolated from the axinellid sponge Agelas dendromorpha of Coral Sea, is a new-skeleton alkaloid with, unusually for oroidin family to which it belongs, marked cytotoxicity toward tumour cells in culture.

Abstract Leucascandrolide A ((+)‐ 1 ), a doubly O‐bridged 18‐membered macrolide of new type, i.e. , showing little C ‐branching vs. extensive 1,3‐dioxygenation and peculiar side chain, was isolated from calcareous sponge genus, Leucascandra caveolata B OROJEVIC K LAUTAU the Coral Sea. Transesterification (+)‐ gave methyl ester 3 derived 5‐hydroxy derivative 2 portion with natural configuration at C(5) (axial). Mosher 's MTPA esters 4 5 obtained showed scattered Δδ = (δ( S ) − δ( R )) data....

Abstract The Mediterranean stolonifer Sarcodictyon roseum (= Rolandia rosea ) (Cnidaria, Anthozoa, Alcyonaria, Stolonifera, Clavulariidae) is shown to contain two novel diterpenoidic alcohols esterified by ( E )‐ N (1)‐methyl‐urocanic acid )‐3‐(l‐methyl‐l H ‐imidazol‐4‐yl)acrylic acid). They are sarcodictyin A = (−)‐(4 R ,4a, , 7 ,10 S ,11 ,12a ,l Z ,5 ,8 )‐7,10‐epoxy‐3,4,4a,7,10,11,12,12a‐octahydro‐7‐hydroxy‐6‐(methoxycarbonyl)‐1,10‐dimethyl‐4‐(1‐methylethyl)benzocyclodecen‐11‐yl...

In Continuous Integration (CI), regression testing is constrained by the time between commits. This demands for careful selection and/or prioritization of test cases within suites too large to be run entirely. To this aim, some Machine Learning (ML) techniques have been proposed, as an alternative deterministic approaches. Two broad strategies ML-based are learning-to-rank and what we call ranking-to-learn (i.e., reinforcement learning). Various ML algorithms can applied in each strategy....

Abstract The green seaweed Caulerpa taxifolia (V AHL ) C. A GARDH (Caulerpales), which, after its recent accidental introduction, is growing in the region of Cap Martin much more vigorously than tropics, shown to contain known sesquiterpenic toxins caulerpenyne ( 1 – larger amounts tropical Caulerpales and oxytoxin 2 ). Novel, potentially toxic products isolated small from this include sesquiterpenes taxifolial = (5 E )‐6,10‐dimethyl‐2‐[( )2‐oxoethylidene]undeca‐5,9‐dien‐7‐ yne‐1,3‐diyl...

Abstract Agelastatin A ( 1 ), an unusual alkaloid of the axinellid sponge Agelas dendromorpha from Coral Sea, can be selectively acetylated (→ 7 ) or methylated at OHC(8a) 4 peracetylated 8 permethylated OHC(8a), NH(5), and NH(6) 5 or, finally, subjected to C(9)C(8a) 14 C(5b)C(8a) β‐elimination 11–13 in a regiospecific manner not, depending on reaction conditions. Under acidic conditions, compound 12 adds H 2 O MeOH, regioselectively though not endo/exo stereoselectively, giving...

Abstract The absolute configuration of agelastatin A ( 1 ), the major, strongly cytotoxic alkaloid axinellid sponge Agelas dendromorpha from Coral Sea, is proposed here to be (5a S ,5b ,8a ,9a R as deduced combined molecular‐mechanics calculations and a novel application exciton splitting bis[4‐(dimethylamino)benzoyl] compounds (–)‐ 9 13 , derivatives diamide hydroxyamide, respectively. position conformational equilibrium could finely tuned by slight molecular changes. minor analogue, B 3...

Abstract It is shown here that the stoloniferan coral Sarcodictyon roseum of east Pyrenean waters contains four novel diterpenoids, sarcodictyin C ((−) ‐3 ), D ‐4 E ((+)‐ 5 F 6 which are related to A ( = (−)‐(4 R ,4a ,7 ,10 S ,11 ,12a ,1 Z ,5 ,8 ‐7,10‐epoxy‐3,4,4a,7,10,11,12,12a‐octahydro‐7‐hydroxy‐6‐(methyoxycarbonyl)‐1,10‐dimethyl‐4‐(1‐methylethyl)‐benzocyclodecen‐11‐yl )‐ N 1 ‐methylyrocanate; ((−)− previously isolated from same coral. Sarcodictyin ) and 3α‐hydroxy 3α‐acetoxy derivatives...

Microservice Architectures (MSA) are nowadays largely adopted by companies in several domains to provide on-demand services. The reliability of microservices is fundamental avoid failures compromising the business functionalities. MSA automated testing possible thanks well-defined service interfaces specified open formats like OpenAPI/Swagger. To support functional and non-functional testing, we define a framework that: (i) generates test cases with valid invalid inputs, executes monitors...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPteridines, Sterols, and Indole Derivatives from the Lithistid Sponge Corallistes undulatus of Coral SeaAntonio Guerriero, Michele D'Ambrosio, Francesco Pietra, Cécile Debitus, Olivier RibesCite this: J. Nat. Prod. 1993, 56, 11, 1962–1970Publication Date (Print):November 1, 1993Publication History Published online1 July 2004Published inissue 1 November...

Abstract Dichloromethane extracts of dried flowers Calendula officinalis contain eight known bioactive triterpendiol monoesters, namely, faradiol‐3‐ O ‐palmitate, ‐myristate, ‐laurate, arnidiol‐3‐ calenduladiol‐3‐ ‐palmitate and ‐myristate. These pentacyclic terpenoids have been quantified simultaneously using reversed‐phase HPLC with isocratic elution internal standardisation. Of the 10 varieties C. investigated, Calypso Orange Florensis produced highest amounts followed by Fiesta Gitana Gelb...

Rings A, D and E of faradiol (1), ring both arnidiol (10) calenduladiol (4) have been subjected to various selective chemical manipulations modify polarity, water affinity, H-bonding, sterics, number aromatic groups these anti-inflammatory natural compounds. A total 15 new four known pentacyclic triterpenoids obtained in this way. Some 13 terpenoids were evaluated for their topical activities with respect inhibition croton oil induced ear oedema mouse. Three derivatives 1, the C(16) benzyl...

Abstract A mixture of sponges the East Pyrenean Mediterranean is shown to contain known sponge products longifolin ( 1 ), avarol ((+)‐ 3 and avarone 4 ) terrestrial‐plant product sesquirosefuran 2 besides new furano‐sesquiterpenoids tavacfuran (= 3‐methyl‐2‐[(3′ Z )‐3′‐methyl‐4″‐methyl‐2″‐furyl‐3′‐butenyl]furan; 5 tavacpallescensin 5,10‐dihydro‐6,9‐dimethyl‐4 H ‐benzo[5,6]cyclohepta[1,2‐ b ]furan; 6 furano‐butenolide sesquiterpenoids tavacbutenolide‐1 (±‐4‐ethoxy‐2‐methyl‐4‐)[(2′ E...

Abstract Natural free carboxylic acids from the hadromerid sponge Diacarnus levii (Kelly‐Borges and Vacelet) were esterified to yield new cyclic norditerpene peroxides ent ‐muqubilin benzyl ester (= (α R ,3 S ,6 )‐α,6‐dimethyl‐6‐[( E )‐4‐methyl‐6‐(2,6,6‐trimethyl‐cyclohex‐1‐en‐1‐yl)hex‐3‐enyl]‐1,2‐dioxan‐3‐acetic acid ester; 6 , diacarnoate B methyl ester(= )‐α,6‐dimethyl‐6‐{2‐(4a ,8a )‐3,4,4a,5,6,7,8,8a‐octahydro‐3‐oxo‐2,5,5,8a‐tetramethylnaphthalen‐1‐yl)ethyl}‐1,2‐dioxan‐3‐acetic 9 ),...

Abstract The tropical green seaweed Caulerpa taxifolia (V AHL ) C. A GARDH (Caulerpales) which is invading the Mediterranean shown to contain trace amounts of two further novel terpenes, 7,7‐ C ‐didehydro‐6‐hydroxy‐6,7‐dihydrocaulerpenyne (= (4 S , 6 ,1 E )‐3‐[( Z )‐acetoxymethylidene]‐6‐hydroxy‐11‐methyl‐7‐methylidenedodeca‐1,10‐dien‐8‐yne‐1,4‐diyl diacetate; 3a and taxifolione 6‐methylhept‐5‐en‐3‐yn‐2‐one; 4 ). former most active toxins so far isolated from this seaweed, both as an in...

Abstract Further investigation of global extracts from cultures the marine deuteromycete Dendryphiella salina leads to isolation three novel trinor‐eremophilanes esterified by branched C 9 ‐carboxylic acids, dendryphiellin B (= (+)‐(1 R *,2 S *,7 *,8a *)‐1,2,6,7,8,8a‐hexahydro‐7‐hydroxy‐1,8a‐dimethyl‐6‐oxonaphthalen‐2‐yl (6 *, 2 E , 4 )‐6‐hydroxy‐6‐methylocta‐2,4‐dienoate; (+)‐ ), (=(+)‐(1 7 8a *)‐1,2,6,7,8,8a‐hexa‐hydro‐7‐hydroxy‐1,8a‐dimethyl‐6‐oxonaphthalen‐2‐yl...