A5085896132- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Proteoglycans and glycosaminoglycans research
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Crystallization and Solubility Studies
- Fluorine in Organic Chemistry
- Atmospheric Ozone and Climate
- Cyclopropane Reaction Mechanisms
- Atmospheric chemistry and aerosols
- Synthesis of Organic Compounds
- Chemical synthesis and alkaloids
- Catalysis for Biomass Conversion
- Organometallic Compounds Synthesis and Characterization
- Microbial Natural Products and Biosynthesis
- Nosocomial Infections in ICU
- Sesquiterpenes and Asteraceae Studies
- Streptococcal Infections and Treatments
- Marine Sponges and Natural Products
- Antibiotic Resistance in Bacteria
- HIV Research and Treatment
- Respiratory and Cough-Related Research
- Enzyme Catalysis and Immobilization
Institute of Medical Sciences
2022-2023
Indian Institute of Science Education and Research Kolkata
2021
Scripps Research Institute
2017-2020
Indian Institute of Science Bangalore
2012-2020
Torrey Pines Institute For Molecular Studies
2019
Scripps (United States)
2019
Scripps Institution of Oceanography
2019
Genomics Research Center, Academia Sinica
2018
University of Delhi
1986
The programmable one-pot oligosaccharide synthesis method was designed to enable the rapid of a large number oligosaccharides, using software Optimer search Building BLocks (BBLs) with defined relative reactivity values (RRVs) be used sequentially in reaction. However, there were only about 50 BBLs measured RRVs original library and could synthesize small oligosaccharides due RRV ordering requirement. Here, we increase include 154 validated more than 50,000 virtual predicted by machine...
Idraparinux is a fully O-sulfated α-methyl glycoside of heparin pentasaccharide motif known to interact with the antithrombin III domain and act as anticoagulant. The current most effective synthesis complicated nonstereoselective, requiring numerous stepwise procedures low yields. We report here an efficient modular one-pot involving use glycosyl phosphate 6-O-tert-butyl diphenyl silyl group d-glucuronic acid-containing disaccharide thioglycoside 6-O-acetyl donor building blocks for...
We report the design of building blocks with optimized reactivities for programmable one-pot synthesis heparin pentasaccharides regiodefined sulfation patterns.
The clinically approved Fondaparinux (Arixtra) has been used for the treatment of deep vein thrombosis and acute pulmonary embolism since 2002 is considered to be better than low-molecular weight heparin in terms anticoagulation response, duration action, biosafety. However, synthetic methods previously developed its manufacture are relatively complicated, thus restricting extensive use. We report here a potentially scalable programmable one-pot synthesis using [1,2,2] strategy designed...
The guaianolide ring containing sesquiterpene thapsigargin is found in the roots and fruits of Mediterranean plant Thapsia garganica L. It known for its activity as a potent antagonist Ca2+-ATPase (sarco–endoplasmic reticulum Ca2+-ATPase) inhibition. Recently, prodrug mipsagargin being investigated to target blood vessel cancer cells treatment tumors. limited natural supply (low isolation only localized growth (Mediterranean area)) from sources strongly urges development chemical synthetic...
Fluorinated glycosides are known to resist the glycosidase-catalyzed glycosidic bond cleavage; however, synthesis of such glycans, especially 3-fluoro-sialic acid (3F-Neu5Ac) containing sialosides, has been a major challenge. Though enzymatic α-2,3-linked 3F-sialosides was reported, until recently there not any effective method available for in α-2,6-linkage. In order understand biological effect modification, we report here chemical 3Fax-Neu5Ac-α2,6-Gal as building block assembly...
This paper deals with the synthesis of 2-deoxy-2- C -alkyl/aryl septanosides. A range such septanoside derivatives was synthesized by using a common bromo-oxepine intermediate, involving C–C bond forming organometallic reactions. Unsaturated, seven-membered vinyl bromides or bromo-oxepines, obtained through ring expansion methodology cyclopropane oxyglycals, displayed good reactivity towards several acceptor moieties in Heck, Suzuki and Sonogashira coupling reactions, thus affording Whereas...
Abstract Conformational analysis of unnatural seven-membered sugars, namely, septanoses and septanosides are discussed herein. The conformational properties these sugars in the solid state, solution phase computational methods presented. analyses reveal that conformations diverse largely unpredictable, as compared furanosides pyranosides.
Echocardiography, a non-invasive diagnostic method that offers insights into cardiac structure, function, and hemodynamics, has emerged as key component of cardiovascular medicine. In span less than five decades, this technique undergone significant evolution, becoming one the most commonly utilized tests after electrocardiography. This article provides concise overview evolutionary development different forms echocardiography.
Humic-like substances (HULIS) are complex macromolecular components of light-absorbing water-soluble organic carbon (brown carbon; BrCaq) consisting polyacidic and monocyclic/polycyclic structures. HULIS contribute to climate forcing via strong absorption at UV near-visible wavelengths, by facilitating the formation cloud condensation nuclei. Consequently, characterization fractions BrC is critical develop a robust understanding its sources, atmospheric processing optical effects. To address...
Light-absorbing organic aerosols, often referred to as brown carbon (BrC), significantly contribute atmospheric clouds and are a major climate forcing agent over South Asia. In addition direct emissions in the form of fine mode aerosol, BrC forms secondarily atmosphere via homogeneous heterogeneous chemical reactions involving anthropogenic biogenic precursor gases, thereby enhancing complexity its molecular composition. Detailed characterization identification potential chromophores...
: was considered as a leading cause of nosocomial respiratory infection and bacteremia in many hospitals all over the world. However, there still debates whether colonization and/or with , increases morbidity mortality independently effect other risk factors. Aim study to isolate among ICU patients, detect carbapenem resistant patients infections determine specific factors outcome due CRAB isolates. A retrospective carried out at Vydehi Institute Medical Sciences RC Bangalore, department...
This article presents a general experimental protocol for programmable one-pot oligosaccharide synthesis and demonstrates how to use Auto-CHO software generating potential synthetic solutions. The approach is designed empower fast of large amounts using thioglycoside building blocks (BBLs) with the appropriate sequential order relative reactivity values (RRVs). cross-platform graphical user interface that provides possible solutions by searching BBL library (containing about 150 validated...