A5103191977- Hernia repair and management
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Pancreatic and Hepatic Oncology Research
- Congenital Diaphragmatic Hernia Studies
- Hemostasis and retained surgical items
- Cancer Cells and Metastasis
- Intestinal and Peritoneal Adhesions
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Surgical Sutures and Adhesives
- Pelvic and Acetabular Injuries
- Minimally Invasive Surgical Techniques
- Reconstructive Surgery and Microvascular Techniques
- Diet and metabolism studies
- Abdominal Surgery and Complications
- Cellular Mechanics and Interactions
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- Blood properties and coagulation
- Hemophilia Treatment and Research
University of Nebraska Medical Center
2016-2025
Nebraska Medical Center
2001-2024
University of Nebraska at Omaha
2014-2024
Omaha VA Medical Center
2010-2023
VA Nebraska Western Iowa Health Care System
2013-2022
St. Luke's Hospital
2019
MARK Resources (United States)
2018
ImmuneXcite (United States)
2014-2015
Creighton University
2015
In-Q-Tel
2014
Growing consensus suggests that frailty-associated risks should inform shared surgical decision making. However, it is not clear how best to screen for frailty in preoperative populations.To develop and validate the Risk Analysis Index (RAI), a 14-item instrument used measure frailty. It can be calculated prospectively (RAI-C), using clinical questionnaire, or retrospectively (RAI-A), variables from quality improvement databases (Veterans Affairs American College of Surgeons National...
<h3>Importance</h3> As the US population ages, number of operations performed on elderly patients will likely increase. Frailty predicts postoperative mortality and morbidity more than age alone, thus presenting opportunities to identify highest-risk surgical improve their outcomes. <h3>Objective</h3> To examine effect Screening Initiative (FSI) complications by comparing outcomes a cohort treated before after implementation FSI. <h3>Design, Setting, Participants</h3> This single-site,...
Postoperative abdominal adhesions are a common problem after surgery and can produce serious complications. Current antiadhesive strategies focus mostly on physical barriers unsatisfactory inefficient. In this study, we designed synthesized advanced injectable cream-like hydrogels with multiple functionalities, including rapid gelation, self-healing, antioxidation, anti-inflammation, anti-cell adhesion. The multifunctional were facilely formed by the conjugation reaction of...
Herein, a robust method to fabricate expanded nanofiber scaffolds with controlled size and thickness using customized mold during the modified gas‐foaming process is reported. The expansion of membranes also simulated computational fluid model. Expanded implanted subcutaneously in rats show cellular infiltration, whereas non‐expanded only have surface attachment. Compared unexpanded scaffolds, more CD68 + CD163 cells are observed within at all tested time points post‐implantation. More CCR7...
Electrospun nanofibers have shown great potential as scaffolds for regenerative medicine because of its biomimicry. However, traditional two-dimensional electrospun nanofiber mats inhibit their applications the dense structure and lack effective cell infiltration. Herein, we report a new method expanding in third dimension using modified gas-foaming technique. The resulting show layered structures with controllable gap widths layer thicknesses on order microns. Expanded possess significantly...
Effective therapies are urgently needed to stabilize patients with marginally compressible junctional hemorrhage long enough get them the hospital alive. Herein, we report injectable and rapidly expandable cryogels consisting of polyacrylamide thrombin (AT cryogels) created by cryo-polymerization for efficient management lethal in swine. The produced have small pore sizes highly interconnected porous architecture robust mechanical strength. exhibit rapid shape memory properties prove be...
We report the outcome in 1,079 consecutive clean or clean-contaminated midline abdominal incisions closed with running 0-loop nylon suture after both elective and emergency operations done between 1984 1991. Postoperatively, 79 patients were lost to follow-up, resulting 1,000 having long-term follow-up. Mean follow-up among these was 22 months. Early wound complications included subcutaneous infection (18), deep (17), dehiscence (13), fistula (2), sinus (2). A ventral hernia developed 42...
Assembling electrospun nanofibers with controlled alignment into three-dimensional (3D), complex, and predesigned shapes has proven to be a difficult task for regenerative medicine. Herein, we report novel approach inspired by solids of revolution that transforms two-dimensional (2D) nanofiber mats thickness once-inaccessible 3D objects shapes. The are highly porous, consisting layers aligned separated gaps ranging from several micrometers millimeters. Upon compression, the able recover...
Reconstruction of complex, craniofacial bone defects often requires autogenous vascularized grafts, and still remains a challenge today. In order to address this issue, we isolated the stromal vascular fraction (SVF) from adipose tissues maintained phenotypes growth endothelial lineage cells within SVF derived (SVFC) by incorporating an cell medium. We 3D bioprinted SVFC our hydrogel bioinks conditioned constructs in either normoxia or hypoxia. found that short-term hypoxic conditioning...
<i>Background/Aims:</i> Primary repair of a large hiatal hernia is associated with published recurrence rate up to 10%; anecdotal rates even higher than this have been reported the authors. The use prosthetic material in other abdominal wall defects has often produced better results primary repair. We wanted compare laparoscopic hiatus hernias reinforced prosthetic. <i>Methods:</i> Thirty-one patients symptomatic gastroesophageal reflux and defect 8 cm or greater were...
Biofilms of multidrug-resistant bacteria in chronic wounds pose a great challenge wound care. Herein, we report the topical delivery molecularly engineered antimicrobial peptides using electrospun nanofiber dressings as carrier for treatment biofilms diabetic wounds. Molecularly human cathelicidin peptide 17BIPHE2 was successfully encapsulated core pluronic F127/17BIPHE2-PCL core–shell nanofibers. The vitro release profiles showed an initial burst followed by sustained over 4 weeks....