A5053111557- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Mast cells and histamine
- Multiple Sclerosis Research Studies
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Mosquito-borne diseases and control
- Artificial Intelligence in Healthcare
- Peripheral Neuropathies and Disorders
- Immunodeficiency and Autoimmune Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Psoriasis: Treatment and Pathogenesis
- Rabies epidemiology and control
- CAR-T cell therapy research
- Insect Resistance and Genetics
- Genetic factors in colorectal cancer
- T-cell and Retrovirus Studies
- Silk-based biomaterials and applications
National Institute of Allergy and Infectious Diseases
2024
National Institute of Neurological Disorders and Stroke
2020-2022
National Institutes of Health
2020-2022
St George’s University Hospitals NHS Foundation Trust
2021
Walton Centre
2021
University of Liverpool
2021
University of Edinburgh
2021
National Health Service
2021
Thomas Jefferson University
2011-2020
Icahn School of Medicine at Mount Sinai
2018-2020
The underlying mechanisms by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to and long-term neurological manifestations remains obscure. We aimed characterize the neuropathological changes in patients with disease 2019 determine pathophysiological mechanisms. In this autopsy study of brain, we characterized vascular pathology, neuroinflammatory cellular humoral immune responses immunohistochemistry. All died during first wave pandemic from March July 2020. were...
ObjectiveTo determine whether the course of COVID-19 is more severe in patients with MS and if disease-modifying treatments (DMTs) affect risk contracting disease.MethodsIn a cross-sectional survey, data were collected by sending questionnaire to 2000 demyelinating disease through an online portal system. Collected included current DMT patient-reported disability level, history recent sick contact, fever, respiratory symptoms, diagnosis COVID-19, disposition after diagnosis. We defined...
Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype poorly defined, pathophysiology unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls conduct deep phenotyping. Among many physical cognitive complaints, one defining feature of was an alteration effort preference, rather than or central fatigue, due dysfunction integrative...
Multiple sclerosis (MS) is an autoimmune disease of the CNS. Studies in animal models MS have shown that GM-CSF produced by T cells necessary for development CNS inflammation. This suggests may a pathogenic role as well, and clinical trial testing its blockade ongoing. However, there been few reports on production MS. The objective this study was to characterize patients determine effect IFN-β therapy production. peripheral blood (PB) effects were characterized samples untreated...
Various peripheral neuropathies, particularly those with sensory and autonomic dysfunction may occur during or shortly after acute COVID-19 illnesses. These appear most likely to reflect immune dysregulation. If similar manifestations can the vaccination remains unknown.
Mast cells (MCs) have been thought to play a pathogenic role in the development of autoimmune diseases, including experimental encephalomyelitis (EAE), an animal model multiple sclerosis. However, immunoregulatory function these has recently suggested. We investigated MCs EAE using W(-sh) mouse strain, which is MC deficient. mice developed earlier and more severe clinical pathological disease with extensive demyelination inflammation CNS. The inflammatory were mainly composed CD4(+) T cells,...
Intravenous (i.v.) injection of a soluble myelin antigen can induce tolerance, which effectively ameliorates experimental autoimmune encephalomyelitis (EAE). We have previously shown that i.v. oligodendrocyte glycoprotein (MOG) induces tolerance in EAE and expands subpopulation tolerogenic CD11c+ CD11b+ dendritic cells (DCs) with an immature phenotype having low expression IA co-stimulatory molecules CD40, CD86, CD80. Here, we further investigate the role DCs by injecting clodronate-loaded...
Abstract One of the most critical challenges in managing complex diseases like COVID-19 is to establish an intelligent triage system that can optimize clinical decision-making at time a global pandemic. The presentation and patients’ characteristics are usually utilized identify those patients who need more care. However, evidence shows unmet determine accurate optimal biomarkers under condition crisis. Here we have presented machine learning approach find group indicators from blood tests...
Contact-mediated interactions between the astrocytic endfeet and infiltrating immune cells within perivascular space are underexplored, yet represent potential regulatory check-points against CNS autoimmune disease disability. Reactive astrocytes upregulate junctional adhesion molecule-A, an immunoglobulin-like cell surface receptor that binds to T via its ligand, integrin, lymphocyte function-associated antigen-1. Here, we tested role of molecule-A in regulating autoinflammatory disease. In...
To study the immunomodulatory effect of dimethyl fumarate (DF) on granulocyte macrophage colony-stimulating factor (GM-CSF) production in CD4+ T cells experimental autoimmune encephalomyelitis (EAE) and human peripheral blood mononuclear (PBMCs).We collected splenocytes from C57BL/6 wild-type interferon (IFN)-γ-deficient mice. For PBMCs, venous was healthy donors, PBMCs were using Percoll gradient method. Cells cultured with anti-CD3/28 presence/absence DF for 3 to 5 days. stained analyzed...