A5018700398- Cancer Genomics and Diagnostics
- Autophagy in Disease and Therapy
- Genetic factors in colorectal cancer
- Bioinformatics and Genomic Networks
- Endoplasmic Reticulum Stress and Disease
- Gene Regulatory Network Analysis
- Bladder and Urothelial Cancer Treatments
- Gene expression and cancer classification
- Renal cell carcinoma treatment
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Glioma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Fractal and DNA sequence analysis
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- RNA Interference and Gene Delivery
- Machine Learning in Bioinformatics
- Artificial Intelligence in Healthcare
- COVID-19 Clinical Research Studies
- Molecular Biology Techniques and Applications
- Protein Kinase Regulation and GTPase Signaling
- Lipid metabolism and biosynthesis
- Cannabis and Cannabinoid Research
ID Genomics (United States)
2020-2024
Icahn School of Medicine at Mount Sinai
2015-2023
Simon Fraser University
2020
National Institute of Neurological Disorders and Stroke
2020
National Institutes of Health
2020
Keio University
2020
keiyu Hospital
2020
Virginia Tech
2011-2015
Georgetown University
2012
Mazandaran University of Medical Sciences
2007
Circulating tumor DNA (ctDNA) can be used for sensitive detection of minimal residual disease (MRD). However, the probability detecting ctDNA in settings low burden is limited by number mutations analyzed and plasma volume available. We a whole-genome sequencing (WGS) approach patients with urothelial carcinoma.
Cells are the basic units of all living matter which harness flow energy to drive processes life. While biochemical networks involved in transduction well-characterized, energetic costs and constraints for specific cellular remain largely unknown. In particular, what budgets cells? What limits flows impose on processes? Do cells operate near these limits, if so how do impact functions? Physics has provided many tools study nonequilibrium systems define physical but applying cell biology...
Autophagy is a conserved biological stress response in mammalian cells that responsible for clearing damaged proteins and organelles from the cytoplasm recycling their contents via lysosomal pathway. In cases of mild stress, autophagy acts as survival mechanism, while severe may switch to programmed cell death. Understanding decision process moves apoptosis important since abnormal regulation occurs many diseases, including cancer. To integrate existing knowledge about this into rigorous,...
The extraction of predictive features from the complex high-dimensional multi-omic data is necessary for decoding and overcoming therapeutic responses in systems pharmacology. Developing computational methods to reduce space vitro, vivo clinical essential discover evolution mechanisms drug resistance. In this paper, we have utilized matrix factorization (MF) as a modality high dimensionality reduction respect, proposed three novel feature selection using mathematical conception basis...
Lack of understanding endocrine resistance remains one the major challenges for breast cancer researchers, clinicians, and patients. Current reductionist approaches to molecular signaling driving have offered mostly incremental progress over past 10 years. As field systems biology has begun mature, network modeling tools being developed applied therein offer a different way think about how regulation critical cellular functions are integrated. To gain novel insights, we first describe some...
The ability to predict responsiveness drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions could be experimentally tested develop transcriptomic signatures for specific drugs. analyzed lung adenocarcinoma patient data Cancer Genome Atlas and identified a subset of which xanthine dehydrogenase (XDH) expression correlated with decreased survival. allopurinol, an FDA-approved drug inhibits XDH, on human...
Abstract Using a gelatin microbial transglutaminase (gelatin-mTG) cell culture platform tuned to exhibit stiffness spanning that of healthy and diseased glomeruli, we demonstrate kidney podocytes show marked sensitivity. Podocyte-specific markers are critical in the formation renal filtration barrier found be regulated association with stiffness-mediated cellular behaviors. While typically de-differentiate diminished physiological function nephropathies characterized by altered tissue...
Understanding the origins of resistance to anti-oestrogen drugs is critical importance many breast cancer patients. Recent experiments show that knockdown GRP78, a key gene in unfolded protein response (UPR), can re-sensitize resistant cells anti-oestrogens, and overexpression GRP78 sensitive cause them become resistant. These results appear arise from operation interaction three cellular systems: UPR, autophagy apoptosis. To determine whether our current mechanistic understanding these...
Abstract One of the most critical challenges in managing complex diseases like COVID-19 is to establish an intelligent triage system that can optimize clinical decision-making at time a global pandemic. The presentation and patients’ characteristics are usually utilized identify those patients who need more care. However, evidence shows unmet determine accurate optimal biomarkers under condition crisis. Here we have presented machine learning approach find group indicators from blood tests...
COVID-19 affects multiple organs. Clinical data from the Mount Sinai Health System show that substantial numbers of patients without prior heart disease develop cardiac dysfunction. How is not known. We integrated cell biological and physiological analyses human cardiomyocytes differentiated induced pluripotent stem cells (hiPSCs) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in presence interleukins (ILs) clinical findings related to laboratory values identify...
Background: Pancreatic cystic lesions are often challenging entities for diagnosis and management. EUS-FNA diagnostic accuracy is limited by paucicellularity of cytology specimens sampling errors. Needle-based confocal laser endomicroscopy (nCLE) provides real-time imaging the microscopic structure lesion could result in a more accurate diagnosis. Aims Objectives: To determine utility vivo nCLE histologic characterization pancreatic (PCL). Materials Methods: All patients diagnosed with PCL...
Abstract Background: Early detection of recurrence and monitoring MRD post-surgery is critical for clinical decision-making to tailor adjuvant therapy. In early-stage NSCLC, circulating tumor DNA (ctDNA) especially challenging, requiring highly sensitive specific assays. Therefore, we used a WGS approach (MRDetect) ultra-sensitive ctDNA in NSCLC patients (pts) undergoing curative surgery. Methods: We conducted pilot study evaluate the MRDetect serial plasma samples (including pre-surgery,...
COVID-19 affects multiple organs. Clinical data from the Mount Sinai Health System shows that substantial numbers of patients without prior heart disease develop cardiac dysfunction. How is not known. We integrate cell biological and physiological analyses human cardiomyocytes differentiated induced pluripotent stem cells (hiPSCs) infected with SARS-CoV-2 in presence interleukins, clinical findings, to investigate plausible mechanisms patients. hiPSC-derived cardiomyocytes, healthy subjects,...
Abstract Circulating tumor DNA (ctDNA) can be used for sensitive detection of minimal residual disease (MRD). However, the probability detecting ctDNA at low burden is limited by number mutations analyzed and available plasma volume. Here we applied a tumor-informed whole genome sequencing (WGS) approach ctDNA-based MRD (91% sensitivity, 92% specificity) treatment response evaluation in 916 longitudinally collected samples from 112 patients with localized muscle-invasive bladder cancer. We...