A5064818146- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Advanced Radiotherapy Techniques
- Pleural and Pulmonary Diseases
- Congenital Diaphragmatic Hernia Studies
- Colorectal Cancer Treatments and Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Reconstructive Surgery and Microvascular Techniques
- Long-Term Effects of COVID-19
- Medical Imaging and Pathology Studies
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- IL-33, ST2, and ILC Pathways
- Cardiac Valve Diseases and Treatments
- Pneumothorax, Barotrauma, Emphysema
National Heart Centre Singapore
2013-2025
Duke-NUS Medical School
2018-2024
National University of Singapore
2019-2024
National Cancer Centre Singapore
2024
SingHealth Duke-NUS Academic Medical Centre
2020
Singapore General Hospital
2019-2020
SingHealth
2018
Riley Hospital for Children
1990
Indiana University – Purdue University Indianapolis
1990
Abstract Background In early‐stage non–small cell lung cancer (NSCLC), recurrence is frequently observed. Circulating tumor DNA (ctDNA) has emerged as a noninvasive tool to risk stratify patients for after curative intent therapy. This study aimed with NSCLC via personalized, tumor‐informed multiplex polymerase chain reaction (mPCR) next‐generation sequencing assay. Methods retrospective cohort included stage I–III NSCLC. Recruited received standard‐of‐care management (surgical resection or...
The recently published ADAURA study has posed a significant dilemma for clinicians in selecting patients adjuvant osimertinib. Risk factors recurrence early-stage epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC) also remain undefined.To determine clinicopathologic characteristics and patterns of resected EGFR-positive NSCLC, using wildtype EGFR as comparator cohort, identify features associated with recurrence.This is cohort including diagnosed AJCC7 Stage...
Abstract Non–small cell lung cancers (NSCLC) in nonsmokers are mostly driven by mutations the oncogenes EGFR, ERBB2, and MET fusions involving ALK RET. In addition to occurring nonsmokers, alterations these “nonsmoking-related oncogenes” (NSRO) also occur smokers. To better understand clonal architecture genomic landscape of NSRO-driven tumors smokers compared with typical-smoking NSCLCs, we investigated transcriptomic 173 tumor sectors from 48 NSCLC patients. NSCLCs had similar landscapes....
AimTo determine the prognostic value of programmed death-ligand 1 (PD-L1) score in early-stage epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), contrasted against EGFR-wildtype NSCLC.MethodsConsecutive patients with Stage IA-IIIA NSCLC diagnosed 1st January 2010–31st December 2019 at National Cancer Centre Singapore evaluable EGFR and PD-L1 status were included. Co-primary end-points 2-year disease-free survival (DFS) 5-year overall (OS) by Kaplan–Meier...
8029 Background: Spread through air spaces (STAS) is a poor prognostic factor and was recently introduced as histologic descriptor in the TNM edition 9 for stage 1 lung cancer. While STAS-positivity (STAS+) known to be associated with adenocarcinoma, molecular epidemiology determinants of STAS+ specific epidermal growth receptor-mutated cancer (EGFRm) implications remain unknown. Methods: Consecutive patients from National Cancer Centre Singapore diagnosed AJCC8 adenocarcinoma minimum 3...
Abstract Background: Early detection of recurrence and monitoring MRD post-surgery is critical for clinical decision-making to tailor adjuvant therapy. In early-stage NSCLC, circulating tumor DNA (ctDNA) especially challenging, requiring highly sensitive specific assays. Therefore, we used a WGS approach (MRDetect) ultra-sensitive ctDNA in NSCLC patients (pts) undergoing curative surgery. Methods: We conducted pilot study evaluate the MRDetect serial plasma samples (including pre-surgery,...
A 49-year-old man with dilated cardiomyopathy who underwent HeartMate II (Thoratec) left ventricular assist device (LVAD) implantation 1 year prior presented cardiac failure secondary to severe aortic regurgitation (AR) requiring inotropic support. He previously developed acute pump thrombosis emergency exchange complicated by right heart temporary VAD …
Abstract: Surgical resection by means of a lobectomy is the treatment choice for early stage non-small cell lung cancer (NSCLC), but disadvantages traditional open has led to interest in exploring other options medically operable patients. Stereotactic body radiotherapy (SBRT) was first developed treat inoperable patients, there now expanding its use We review current evidence comparing surgery versus SBRT NSCLC, and conclude that still favors eligible Furthermore, recent advances field...
Abstract: Early results indicate that uniportal video-assisted thoracoscopic surgery (VATS) may have advantages over multi-port VATS in terms of patient outcome. A masterclass was conducted at the National Heart Centre Singapore, order to increase adoption Singapore.
Abstract Background Video-assisted thoracoscopic (VATS) lung resections are increasingly popular and localization techniques necessary to aid resection. We describe our experience with hybrid operating room (OR) cone-beam computed tomography (CT) assisted pre-operative intra-operative lesion of nodules for VATS wedge resections, including novel workflow using the OR CT re-evaluate patients who have undergone those unsuitable localization. Methods Retrospective analysis all consecutive small...