A5103179078- Human-Animal Interaction Studies
- Cancer Genomics and Diagnostics
- Genetic and phenotypic traits in livestock
- Plant Pathogens and Fungal Diseases
- Fungal Biology and Applications
- Genomics and Phylogenetic Studies
- Yersinia bacterium, plague, ectoparasites research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ferroptosis and cancer prognosis
- Genetic diversity and population structure
- Wildlife Ecology and Conservation
- Hepatocellular Carcinoma Treatment and Prognosis
- Zoonotic diseases and public health
- Primate Behavior and Ecology
- Bat Biology and Ecology Studies
- Livestock and Poultry Management
- Child Nutrition and Water Access
- Advanced battery technologies research
- Agronomic Practices and Intercropping Systems
- Amphibian and Reptile Biology
- melanin and skin pigmentation
- Infectious Diseases and Mycology
- Plant Stress Responses and Tolerance
- Human Rights and Development
- Aquatic Ecosystems and Phytoplankton Dynamics
Agency for Science, Technology and Research
2017-2024
Chinese Academy of Sciences
2013-2024
Genecast (China)
2024
Genome Institute of Singapore
2017-2024
Institute of Zoology
2019-2024
Tianjin University
2024
Sichuan Agricultural University
2023
Key Laboratory of Zoological Systematics and Evolution
2019
Liaoning Academy of Agricultural Sciences
2018
Kunming Institute of Zoology
2010-2017
The origin and evolution of the domestic dog remains a controversial question for scientific community, with basic aspects such as place date origin, number times dogs were domesticated, open to dispute. Using whole genome sequences from total 58 canids (12 gray wolves, 27 primitive Asia Africa, collection 19 diverse breeds across world), we find that southern East have significantly higher genetic diversity compared other populations, are most basal group relating indicating an ancient in...
As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to limited effectiveness, immunotherapy becomes a compelling way tackle disease. We aim provide humanised mouse (humice) models understanding of interaction between cancer and immune system, particularly human-specific drug testing.
The high-altitude hypoxic environment represents one of the most extreme challenges for mammals. Previous studies humans on Tibetan plateau and in Andes Mountains have identified statistical signatures selection different sets loci. Here, we first measured hemoglobin levels village dogs from Tibet those Chinese lowlands. We found that are very similar between two groups, suggesting might share adaptive strategies as people. Through a whole-genome sequencing approach, EPAS1 HBB candidate...
The objective of this study was to investigate whether plant-bacteria interaction affects the secretion organic acids by both organisms and assess production IAA bacterium increases root exudates, if stress produced low available phosphorus (P) bacteria, roots, or exudates in presence bacterial cultures. With purpose, we used as a biological model poplar plants one strain Burkholderia multivorans able solubilize P. High performance liquid chromatography utilized measure acids. tests,...
The rapid advancement of next-generation sequencing technology has generated a deluge genomic data from domesticated dogs and their wild ancestor, grey wolves, which have simultaneously broadened our understanding domestication diseases that are shared by humans dogs. To address the scarcity single nucleotide polymorphism (SNP) provided authorized databases to make SNP more easily/friendly usable available, we propose DoGSD (http://dogsd.big.ac.cn), first canidae-specific database focuses on...
Intra-tumor heterogeneity (ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic (transcriptomic and immune) heterogeneity. Using one of largest prospective surgical cohorts for hepatocellular carcinoma (HCC) with multi-region sampling, we sequenced whole genomes paired transcriptomes from 67 HCC patients (331 samples). We found that while ITH was rather constant across stages, had very different...
Significance Central topics in evolutionary biology include uncovering the processes and genetic bases of speciation documenting environmental adaptations responsible for them. The challenging environment Qinghai-Tibetan Plateau (QTP) facilitates such investigations, Tibetan frog, Nanorana parkeri , offers a unique opportunity to investigate these processes. A cohort whole-genome sequences 63 individuals from across its entire range opens avenues incorporating population genomics into...
Natural selection in domestic dogs is of great interest evolutionary biology since have migrated to every inhabited continent the world alongside humans, and adapted diverse environments. Here, we explored their demographic history genetic basis adaptation tropical African environment using whole genome analyses 19 indigenous from Nigeria. Demographic analysis suggests that ancestors these into Africa Eurasia 14,000 years ago underwent a severe founder effect before population expansion....
Abstract In this study, S-CCO@Co(OH) 2 (‘CCO’ representing CuCo O 4 /Cu O; ‘S-’representing sulfur doping) was synthesized by hydrothermal method followed electrodeposition. The multiple effects of S doping were studied and constructing 3D core–shell structure. induced the reduction Cu 2+ Co 3+ to + , respectively. Also, partially replaces creates oxygen vacancies, which increases a number active sites for redox reaction enhancing activity. After electrodeposition, S–Co bond is formed...
Hepatocellular carcinoma (HCC) is a highly fatal cancer characterized by high intra-tumor heterogeneity (ITH). A panoramic understanding of its tumor evolution, in relation to clinical trajectory, may provide novel prognostic and treatment strategies.
Heat stress can hinder the growth of perennial ryegrass (Lolium perenne L.). Methyl jasmonate (MeJA) applied exogenously increase heat tolerance in plants; however, regulatory mechanisms involved mediated by MeJA are poorly understood ryegrass. Here, microRNA (miRNA) expression profiles were assessed to elucidate pathways associated with induced MeJA. Plants subjected four treatments, namely, control (CK), pre-treatment (T), treatment (H), and + (TH). According results, 102 miRNAs...
East Asian dog breeds are one of the most ancient groups dogs that radiated after domestication and represent basal lineages evolution. Among these, Chow is an breed embodies very distinct morphological physiological features, such as sturdy build, dense coat, blue/purple tongue.Using a Restricted site Associated DNA (RAD) sequencing approach, we sequenced genomes nine Chows from China. Combined with dataset 37 canid whole genome (WGS) several published works, found lineages, which...
PURPOSE Simultaneous profiling of cell-free DNA (cfDNA) methylation and fragmentation features to improve the performance cfDNA-based cancer detection is technically challenging. We developed a method comprehensively analyze multimodal cfDNA genomic for more sensitive esophageal squamous cell carcinoma (ESCC) detection. MATERIALS AND METHODS Enzymatic conversion–mediated whole-methylome sequencing was applied plasma samples extracted from 168 patients with ESCC 251 noncancer controls....
Hepatocellular carcinoma (HCC) is one of the deadliest cancer types with diverse etiological factors across world.Although large scale genomic studies have been conducted in different countries, integrative analysis HCC genomes and ethnic comparison cohorts are lacking.Methods: We first integrated 1,349 patients from five world applied multiple statistical methods identifying driver genes.Subsequently, we systematically compared transcriptomes between Asians Europeans using TCGA...
Simulating realistic clonal dynamics of tumors is an important topic in cancer genomics. Here, we present Phylogeny guided Simulator for Tumor Evolution, a tool that can simulate different types tumor samples including single sector, multi-sector bulk as well single-cell data under wide range evolutionary trajectories. Evolution provides efficient understanding evolution cancer.PSiTE implemented Python and available at https://github.com/hchyang/PSiTE.Supplementary are Bioinformatics online.
Quality deficiencies in single nucleotide polymorphism (SNP) analyses have important implications. We used missingness rates to investigate the quality of a recently published dataset containing 424 mitochondrial, 211 Y chromosomal, and 160 432 autosomal SNPs generated by semicustom Illumina SNP array from 5 392 dogs 14 grey wolves. Overall, individual rate for mitochondrial was ~43.8%, with 980 (18.1%) individuals completely missing genotyping (missingness rate=1). In males, genotype ~28.8%...