A5063942399- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Berberine and alkaloids research
- Mast cells and histamine
- Extracellular vesicles in disease
- Immune responses and vaccinations
- Protein Kinase Regulation and GTPase Signaling
- interferon and immune responses
- Long-Term Effects of COVID-19
- PI3K/AKT/mTOR signaling in cancer
- Natural Antidiabetic Agents Studies
- Ziziphus Jujuba Studies and Applications
- IL-33, ST2, and ILC Pathways
- Mental Health Research Topics
- Immunotherapy and Immune Responses
- Gallbladder and Bile Duct Disorders
- Tryptophan and brain disorders
- Genetics, Aging, and Longevity in Model Organisms
- Hepatitis C virus research
- Cytokine Signaling Pathways and Interactions
- Computational Drug Discovery Methods
- Tissue Engineering and Regenerative Medicine
- T-cell and B-cell Immunology
Shiraz University of Medical Sciences
2018-2024
Shiraz University
2020-2024
As the outbreak of COVID-19 has accelerated, an urgent need for finding strategies to combat virus is growing. Thus, gaining more knowledge on pathogenicity mechanisms SARS-CoV-2, causing agent COVID-19, and its interaction with immune system utmost importance. Although this novel not well known yet, structural genetic similarity SARS-CoV as comparable pattern age-mortality relations suggest that previous findings SARS can be applicable COVID-19. Therefore, a systems biology study was...
Background: As the outbreak of COVID-19 has accelerated, an urgent need for finding strategies to combat virus is growing. Thus, gaining more knowledge on pathogenicity mechanism SARS-CoV-2, i.e. causing agent COVID-19, and its interaction with immune system utmost importance. Although this novel not well known yet, structural genetic similarity SARS-CoV as comparable pattern age-mortality relations suggest that some previous findings SARS could be applicable COVID-19. Objective: The aim...
As the outbreak of COVID-19 has accelerated, an urgent need for finding strategies to combat virus is growing. Thus, gaining more knowledge on pathogenicity mechanism SARS-CoV-2, causing agent COVID-19, and its interaction with immune system utmost importance. Although this novel not well known yet, structural genetic similarity SARS-CoV as comparable pattern age-mortality relations suggest that previous findings SARS can be applicable COVID-19. Therefore, a systems biology study was...
Aging is correlated with several complex diseases, including type 2 diabetes, neurodegeneration and cancer. Identifying the nature of this correlation treatment age-related diseases has been a major subject both modern traditional medicine. Traditional Persian Medicine (TPM) embodies many prescriptions for ARDs. Given that autophagy plays critical role in antiaging processes, present study aimed to examine whether documented effect plants used TPM might be relevant induction autophagy? To...
No proven remedy is identified for COVID-19 yet. SARS-CoV-2, the viral agent, recognized by some endosomal and cytosolic receptors following cell entry, entailing innate adaptive immunity stimulation, notably through interferon induction. Impairment in activation patients, mostly elderlies, leads to high mortalities; thus, promoting immune responses may help. BCG vaccine under investigation prevent due its non-specific effects on system. However, other complementary immune-induction methods...
Some studies have investigated the potential role of transposable elements (TEs) in COVID-19 pathogenesis and complications. However, to best our knowledge, there is no study examine possible association TE expression cell functions its immune response at single-cell level. In this study, we reanalyzed RNA seq data bronchoalveolar lavage (BAL) samples obtained from six severe patients three healthy donors assess probable correlation with responses induced by acute respiratory syndrome...
Abstract Signal integration in the mTOR pathway plays a vital role cell fate decision making cancer cells. As signal integrator, shows complex dynamical behavior which determines at different cellular processes levels including cycle progression, survival, death, metabolic reprogramming, and aging. The dynamics of responses to rapamycin cells have been attributed its differential time-dependent inhibitory effects on mTORC1 mTORC2, two main complexes mTOR. Two explanations were previously...
Coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a pandemic with immense impacts on different aspects human life globally. Generally, type I and II interferons are essential cytokines to combat viral infections including COVID-19. However, SARS-CoV-2 adopts evasion mechanisms overcome interferon-mediated antiviral responses neutralizes key defensive strategy. The aim this mini-review is survey both beneficial...
Abstract Background: Multiple sclerosis (MS) is a chronic and often immune-mediated demyelinating disease with no absolute treatment. Transposable elements (TEs) are getting more attention as possible culprit in neurodegenerative disease. However, to the best of our knowledge, there study examine association TE expression its potential role MS pathogenesis at single-cell level. Result: In this study, we reanalyzed RNA sequencing data human cerebrospinal fluid (CSF) samples. Our result...
Abstract Some studies investigated the potential role of transposable elements (TEs) in COVID-19 pathogenesis and complications. However, to best our knowledge, there is no study examine possible association TEs expression cell functions its immune response at single-cell level. In this study, we reanalyzed RNA seq data bronchoalveolar lavage (BAL) samples obtained from six severe patients three healthy donors assess probable correlation TE with responses induced by SARS-CoV-2 virus...
Background: Major Depressive Disorder (MDD) is a prevalent mental health condition that affects significant portion of the general population. Despite availability pharmacological, psychological, and novel neurological approaches, optimal outcomes are only achieved in roughly 50% patients. Traditional Persian Medicine (TPM) recommends holistic approach to cure diseases based on etiologic cause malfunctions. This study aimed explore potential integrating TPM systems pharmacology approaches...
Background: Toll-Like Receptors (TLRs) are a subclass of pathogen-associated molecular patterns (PAMPs). There is growing interest in the use TLR agonists for various pathological dysfunctions, including cancer, microbial infections, and inflammatory diseases. TLR3/4 that can induce TIR-domain-containing adapter-inducing interferon-β (TRIF)- dependent pathway have shown fewer toxic immunostimulatory responses comparison to other small molecules. Furthermore, TLR3 indicate promising...
An amendment to this paper has been published and can be accessed via a link at the top of paper.