A5010517713- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
Chinese Academy of Sciences
2022
Guangzhou Institutes of Biomedicine and Health
2022
Guangzhou Medical University
2022
Abstract Pluripotent stem cells hold great promise in regenerative medicine and developmental biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle intermediates, have been reported to play critical roles pluripotency. Here we show that TCA enzymes Pdha1, Pcb, Aco2, Cs, Idh3a, Ogdh, Sdha Mdh2 are translocated the nucleus during somatic cell reprogramming, primed-to-naive transition totipotency acquisition. The nuclear-localized Idh3a promote reprogramming...