A5000133165- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Receptor Mechanisms and Signaling
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Respiratory viral infections research
- Pharmaceutical studies and practices
- Eosinophilic Esophagitis
- Neuropeptides and Animal Physiology
- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Contact Dermatitis and Allergies
- Respiratory Support and Mechanisms
- Macrophage Migration Inhibitory Factor
- Gastroesophageal reflux and treatments
- Child Nutrition and Feeding Issues
- Immune Cell Function and Interaction
- Olfactory and Sensory Function Studies
- Obesity, Physical Activity, Diet
- School Health and Nursing Education
Children's Hospital of Orange County
2015-2025
University of California, Irvine
2011-2025
University of California, Irvine Medical Center
1975-2023
Nationwide Children's Hospital
2023
University of Mississippi Medical Center
2021
State Street (United States)
2021
American College of Allergy, Asthma and Immunology
2021
CHOC Foundation
2011-2019
Asthma and Allergy Foundation of America
2007-2011
Irvine University
2011
β-ADRENERGIC catecholamines, which modulate function of a variety tissues, are assumed to act by initially binding receptors on target-cell plasma membranes, thereby activating adenylate cyclase and stimulating generation adenosine 3′:5′-monophosphate (cyclic AMP). In addition cyclase, β-adrenergic agonists commonly have second action — regulation responsiveness the target cells. Thus, continued treatment with such often results in decreased cellular response. This self-regulation...
We measured the neutrophil function of 6 patients with AIDS and Kaposi's sarcoma (KS); 22 AIDS-related complex (ARC); 28 healthy, heterosexual controls. Neutrophils from ARC showed significantly less chemotaxis (P than or equal to .025) did those KS Serum .05) inhibited neutrophils controls; heat treatment serum abolished this inhibitory effect. Bacterial killing by was also for controls, as phagocytosis binding Candida albicans .05). Expression OKM1 antigen increased in studied. Enzyme...
We have tested the beta adrenergic receptor theory of bronchial asthma by determining number and affinity binding sites radioligand [(3)H]dihydroalprenolol (DHA) activity adenylate cyclase in broken cell preparations polymorphonuclear leukocytes (PMN). studied 31 control subjects (group 1), 30 asthmatics receiving no systemic medication 2), 17 agonists systemically 3). Control taking drugs bound similar amounts DHA at 0.5 nM had about 900 per PMN. In contrast, a >70% decrease their PMN...
The exhaled nitric oxide (eNO) signal is a marker of inflammation, and can be partitioned into proximal [J'awNO (nl/s), maximum airway flux] distal contributions [CANO (ppb), airway/alveolar NO concentration]. We hypothesized that J'awNO CANO are selectively elevated in asthmatics, permitting identification four inflammatory categories with distinct clinical features. In 200 consecutive children asthma, 21 non-asthmatic, non-atopic controls, we measured baseline spirometry, bronchodilator...
The coronavirus disease 2019 (COVID-19) pandemic period is experiencing better asthma control, fewer exacerbations, and health care utilization, with limited data on factors that could explain this phenomenon.To confirm these improved outcomes during COVID-19 evaluate potential contributing factors.In 18,912 pediatric patients treated in the Children's Hospital of Orange County network from 2017 to 2020, monthly asthma-related encounters medication summaries were extracted electronic...
Urban minority children have higher rates of asthma morbidity due to multiple factors. Many school-based programs been funded improve management, especially for these "high-risk" inner-city with asthma. Here we report the outcomes Children's Hospital Orange County Breathmobile program, which is a program that combines use mobile clinic and pediatric specialist. Baseline evaluations included detailed history physical, skin prick test common allergens, spirometry measurements, severity...
Asthma is related to school absenteeism and underperformance in elementary students. This pilot study assessed whether nurse case management (CM) children identified with asthma impacts academic performance one school. A validated questionnaire was used identify at risk for CM provided link these students medical care assure action plans In the 40 confirmed diagnosis who received CM, on standardized testing postintervention similar 76 were low asthma. Average days absent due illness group...
Summary Nineteen patients with delayed onset food sensitivity were compared fourteen immediate reactions and twenty‐one non‐atopic subjects in terms of clinical symptoms, foods involved IgE mediated immunological reactions. The reactors frequently positive to all tests used: skin (71%), allergen induced leucocyte histamine release radioimmunodiffusion (55%) window (55%). Those the variety seldom by testing (13%), or (0%), while 39% 48% demonstrated specific antibodies. Control had negative...