Abstract A long-standing challenge in synthetic chemistry is the development of transamidation reaction. This process, which involves conversion one amide to another, typically plagued by unfavourable kinetic and thermodynamic factors. Although some advances have been made with regard primary substrates, secondary has remained elusive. Here we present a simple two-step approach that allows for elusive overall transformation take place using non-precious metal catalysis. The methodology...

Allene (C3H4) gas is produced and separated on million-metric-ton scale per year during petroleum refining but rarely employed in organic synthesis. Meanwhile, the addition of an allyl group (C3H5) to ketones among most common prototypical reactions synthetic chemistry. Herein, we report that combination allene with inexpensive environmentally benign hydrosilanes, such as PMHS, can serve a replacement for stoichiometric quantities allylmetal reagents, which are required enantioselective...

Abstract A direct oxidative cyanation of arenes under Fe II catalysis with 3,5‐di(trifluoromethyl)phenyl(cyano)iodonium triflate (DFCT) as the cyanating agent has been developed. The reaction is applicable to wide range aromatic substrates, including polycyclic structures and heteroaromatic compounds.

Abstract A strategy to introduce the SCF 3 group through Cu I ‐promoted reaction of diazo compounds with nucleophilic AgSCF trifluoromethylthiolation reagent was developed. Various were smoothly converted under mild conditions form C(sp )–SCF bond. Mechanistically, migratory insertion ‐bearing carbene intermediates is involved in this transformation.

The direct asymmetric copper hydride (CuH)-catalyzed coupling of α,β-unsaturated carboxylic acids to aryl alkenes access chiral α-aryl dialkyl ketones is reported. A variety substrate substitution patterns, sensitive functional groups, and heterocycles are tolerated in this reaction, which significantly expands the range accessible products compared with existing hydroacylation methodology. Although mechanistic studies ongoing, we propose that CuH-catalyzed silylation unsaturated occurs a...

A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing broad range functional groups.

Herein, we describe an efficient method to prepare polysubstituted pyrroles via a copper hydride (CuH)-catalyzed enyne-nitrile coupling reaction. This protocol accommodates both aromatic and aliphatic substituents broad range of functional groups, providing variety N-H in good yields with high regioselectivity. We propose that the Cu-based catalyst promotes initial reductive subsequent cyclization steps. Density theory (DFT) calculations were performed elucidate reaction mechanism.

Abstract Pd‐catalyzed cross‐coupling of halides with CF 3 ‐substituted diazo compounds or N ‐tosylhydrazones has been explored for the synthesis alkenes and 1,3‐butadienes. Pd–carbene migratory insertion plays key role in these transformations.

The copper hydride (CuH)-catalyzed enantioselective reduction of α,β-unsaturated carboxylic acids to saturated aldehydes is reported. This protocol provides a new method access variety β-chiral in good yields, with high levels enantioselectivity and broad functional group tolerance. A reaction pathway involving ketene intermediate proposed based on preliminary mechanistic studies density theory calculations.

Vinyl sulfonates are vital intermediates in organic synthesis, serving as versatile electrophiles various cross-coupling reactions. Despite their significance, direct methods for synthesizing vinyl from styrenes have been limited. In this study, we introduce an innovative electrochemical approach that leverages bromine radical mediation to facilitate the synthesis of sulfonates, cheap nBu4NBr acts both electrolyte and a catalytic amount. This process involves reaction with sodium sulfinates...

An efficient method for the synthesis of organophosphonates through palladium-catalyzed coupling α-diazo phosphonates with benzyl or allyl halides has been developed. Trisubstituted alkenylphosphonates bearing versatile functional groups can be easily accessed in good yields and excellent stereoselectivity this method. Moreover, similar strategy α-substituted vinylphosphonates also attained by reaction N-tosylhydrazones aryl bromides. Migratory insertion palladium carbene is proposed as key...

Power allocation is important for dynamic dual-pickup wireless charging system of electric vehicles (EVs). The existing power methods transfer technology mainly focus on allocating the to loads according needs with different resonant frequencies. However, issues inaccuracy and low are still not well solved by methods. In addition, control strategies complex difficult implement in practical situations. this paper, a new method proposed, which can dynamically precisely allocate loads....

A novel strategy to synthesize 1,3-enynes has been successfully developed based on Cu(I)-catalyzed cross-coupling of α-diazo phosphonates and alkynes with a subsequent Horner–Wadsworth–Emmons (HWE) type reaction. This method provides straightforward access conjugated enynes high efficiency, good stereoselectivity excellent functional group compatibility. Copper(I) carbene migratory insertion plays crucial role in this transformation.

A general approach towards diverse fluorinated phosphonates <italic>via</italic> geminal difunctionalization reactions of α-diazo arylmethylphosphonates is reported.

A palladium-catalyzed synthesis of polysubstituted indoles and isoquinolines through the coupling aryl bromides with 2-alkynyl arylazides or benzylazides has been developed. This method provides straightforward access to high efficiency excellent functional group compatibility. In this transformation, iminophosphorane in situ generated from azides is served as nucleophile that attacks alkyne moiety cyclization process.

Abstract A direct oxidative cyanation of arenes under Fe II catalysis with 3,5‐di(trifluoromethyl)phenyl(cyano)iodonium triflate (DFCT) as the cyanating agent has been developed. The reaction is applicable to wide range aromatic substrates, including polycyclic structures and heteroaromatic compounds.

A combinatorial synthesis of pyrrolo[3,2-f]quinoline and pyrrolo[3,2-a]acridine derivatives is described as a three-component reaction aromatic aldehyde, 1H-indol-5-amine, 1,3-dicarbonyl compounds under catalyst-free conditions. The include 5,5-dimethylcyclohexane-1,3-dione, cyclopentane-1,3-dione, 2H-indene-1,3-dione. It interesting that the designed reactions gave aromatized or unaromatized products, which depend on temperature reactants compounds.

The direct enantioselective copper hydride (CuH)-catalyzed synthesis of β-chiral amides from α,β-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. method utilizes readily accessible tolerates a variety functional groups in the β-position including several heteroarenes. A subsequent iridium-catalyzed reduction to γ-chiral can be performed same flask without purification intermediate amides.

Alkenyl nitriles can be easily accessed by Pd(<sc>ii</sc>)-catalyzed reaction of allyl arenes with <italic>tert</italic>-butyl nitrite as both the nitrogen source and oxidant <italic>N</italic>-hydroxyphthalimide co-catalyst.