A5054174994- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Amino Acid Enzymes and Metabolism
- Mitochondrial Function and Pathology
- Tryptophan and brain disorders
- Neuroscience and Neural Engineering
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience of respiration and sleep
- Marine animal studies overview
- Medicinal Plants and Neuroprotection
- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Olfactory and Sensory Function Studies
- Epigenetics and DNA Methylation
- Genetic Neurodegenerative Diseases
Laboratoire Lumière, Matière et Interfaces
2023
Institut de Psychiatrie et Neurosciences de Paris
2008-2022
CentraleSupélec
2021-2022
Université Paris-Saclay
2021-2022
Centre National de la Recherche Scientifique
2021-2022
Inserm
2006-2021
Sorbonne Paris Cité
2011-2021
Université Paris Cité
2009-2021
Délégation Paris 5
2006-2021
Laboratoire Aimé Cotton
2018-2019
The hippocampal slice preparation was used to classify cholinergic effects in terms of muscarinic receptor subtypes (M1 or M2) and biochemical effector systems linked these CA1 pyramidal cells. Based on the action M1 antagonist pirenzepine M2 gallamine, muscarinic-induced membrane depolarization blockade afterhyperpolarization appear result from activation an receptor, while depression EPSP a potassium current termed M-current appears involve receptor. All actions could be observed pertussis...
An association between age-related memory impairments and changes in functional plasticity the aging brain has been under intense study within last decade. In this article, we show that an impaired activation of strychnine-insensitive glycine site N-methyl-d-aspartate receptors (NMDA-R) by its agonist d-serine contributes to deficits synaptic hippocampus memory-impaired aged rats. Supplementation with exogenous prevents isolated NMDA-R-dependent potentials as well those theta-burst-induced...
Chemokines are signaling molecules playing an important role in immune regulations. They also thought to regulate brain development, neurogenesis and neuroendocrine functions. While chemokine upsurge has been associated with conditions characterized cognitive impairments, their ability modulate synaptic plasticity remains ill-defined. In the present study, we specifically evaluated effects of MIP1-α/CCL3 towards hippocampal transmission, spatial memory. We found that CCL3 (50 ng/ml)...
Alzheimer's disease (AD) is characterized by both amyloid and Tau pathologies. The component altered cholesterol metabolism are closely linked, but the relationship between pathology currently unclear. Brain synthesized in situ cannot cross blood-brain barrier: to be exported from central nervous system into blood circuit, excess must converted 24S-hydroxycholesterol 24-hydroxylase encoded CYP46A1 gene. In AD patients, concentration of plasma cerebrospinal fluid lower than healthy controls....
The influx of calcium into the postsynaptic neuron is likely to be an important event in memory formation. Among mechanisms that nerve cells may use alter time course or size a spike intracellular are cytosolic binding "buffering" proteins. To consider role formation one these proteins, calbindin D28K, which abundant many neurons, including CA1 pyramidal hippocampus, transgenic mice deficient D28K have been created. These show selective impairments spatial learning paradigms and fail...
Cholinergic and GABAergic neurons in the medial septum-diagonal band of Broca (MS-DB) project to hippocampus where they are involved generating theta rhythmicity. So far, functional properties neurochemically identified MS-DB not fully characterized. In this study, recorded urethane anesthetized rats unanesthetized restrained were labeled with neurobiotin processed for immunohistochemistry against glutamic acid decarboxylase (GAD), parvalbumin (PV), choline acetyltransferase (ChAT). The...
Summary Age‐associated deficits in learning and memory are closely correlated with impairments of synaptic plasticity. Analysis N ‐methyl‐D‐aspartate receptor (NMDAr)‐dependent long‐term potentiation (LTP) CA1 hippocampal slices indicates that the glial‐derived neuromodulator d ‐serine is required for induction During aging, content expression its synthesizing enzyme serine racemase significantly decreased hippocampus. Impaired LTP NMDAr‐mediated potentials old rats rescued by exogenous...
Dutar, Patrick, Huan M. Vu, and David J. Perkel. Multiple cell types distinguished by physiological, pharmacological, anatomic properties in nucleus HVc of the adult zebra finch. Neurophysiol. 80: 1828–1838, 1998. Nucleus songbird is a distinct forebrain region that essential for song production shows selective responses to complex auditory stimuli. Two neuronal populations within give rise its efferent projections. One projection, robust archistriatum (RA), serves as primary motor pathway...
The memory deficits associated with Alzheimer's disease result to a great extent from hippocampal network dysfunction. coordination of this relies on theta (symbol) oscillations generated in the medial septum. Here, we investigated rats impact amyloid beta (Abeta) injections physiological and cognitive functions that depend septohippocampal system. Hippocampal Abeta progressively impaired behavioral performances, power, frequency response visuospatial recognition test. These alterations were...
This study aims to determine whether the regulation of extracellular glutamate is altered during aging and its possible consequences on synaptic transmission plasticity. A decrease in expression glial transporters GLAST GLT-1 reduced uptake occur aged (24-27 months) Sprague-Dawley rat hippocampus. Glutamatergic excitatory postsynaptic potentials recorded extracellularly ex vivo hippocampal slices from adult (3-5 rats are depressed by DL-TBOA, an inhibitor transporter activity,...
Somatostatin is highly expressed in mammalian brain and involved many functions such as motor activity, sleep, sensory cognitive processes. Five somatostatin receptors have been described: sst1, sst2 (A B), sst3 to 5, all belonging the G-protein-coupled receptor family. During recent years, numerous studies contributed clarify role of systems, especially long-range somatostatinergic interneurons, several they previously in. New advances also made on alterations SRIF systems diseases...
Oxidative stress (OS) resulting from an imbalance between antioxidant defenses and the intracellular accumulation of reactive oxygen species (ROS) contributes to age-related memory deficits. While impaired synaptic plasticity in neuronal networks is thought underlie cognitive deficits during aging, whether this process targeted by OS what mechanisms involved are still remain open questions. In study, we investigated effects reducing agent N-acetyl-L-cysteine (L-NAC) on activation...
Research Article1 October 2018Open Access Source DataTransparent process Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator Snehajyoti Chatterjee orcid.org/0000-0002-4873-9416 Laboratoire de Neuroscience Cognitives et Adaptatives (LNCA), Université Strasbourg, France LNCA, CNRS UMR 7364, Search for more papers by this author Raphaelle Cassel Anne Schneider-Anthony Karine Merienne Brigitte Cosquer Laura Tzeplaeff Sarmistha Halder Sinha...
1. Glutamate, acetylcholine (ACh), and bicuculline were delivered by iontophoretic pipettes to the 545 neurons described in preceding paper. Their response properties examined determine effect of these compounds on behavior rat somatosensory cortex. 2. The responses glutamate covered a broad range. Some cells completely depolarized small amounts this excitatory amino acid, whereas others extremely insensitive requiring excess 100 nA be excited. This range sensitivities was seen throughout...