A5007921322- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Monoclonal and Polyclonal Antibodies Research
- Multiple Myeloma Research and Treatments
- Autoimmune Neurological Disorders and Treatments
- Myasthenia Gravis and Thymoma
- Chronic Lymphocytic Leukemia Research
- Long-Term Effects of COVID-19
- Nerve injury and regeneration
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sphingolipid Metabolism and Signaling
- Peripheral Nerve Disorders
- Toxin Mechanisms and Immunotoxins
- Cancer Mechanisms and Therapy
- Pain Mechanisms and Treatments
- Immune Cell Function and Interaction
- Lipid Membrane Structure and Behavior
- Cellular transport and secretion
- CAR-T cell therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Veterinary medicine and infectious diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
IRCCS Humanitas Research Hospital
2022-2025
University of Turin
2022-2024
Humanitas University
2007-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2021
Fondazione IRCCS Istituto Neurologico Carlo Besta
2019
University of Pavia
2019
University College London
2019
University of Milan
2003-2013
Ferrari (Italy)
2009
To assess the prevalence and isotypes of anti-nodal/paranodal antibodies to nodal/paranodal proteins in a large chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) cohort, compare clinical features seronegative vs seropositive patients, gather evidence their isotype-specific pathogenic role.
Changes in adenosine receptors and neurotrophic factors the SOD1G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine,
<h3>Background</h3> Increased titres of serum IgM antibodies to GM1 ganglioside are often associated with multifocal motor neuropathy (MMN). Testing for other antigens including GM2, the mixture and galactocerebroside (GM1/GalC) disulfated heparin disaccharide NS6S were reported increase sensitivity antibody testing in MMN even if it is unclear whether specificity positive (PPV) or negative predictive value (NPV) also affected. <h3>Methods</h3> We measured GM1, galactocerebroside, GM1/GalC...
Treatment with methyl-β-cyclodextrin (MCD) induced a time- and dose-dependent efflux of cholesterol, sphingolipids, phosphatidylcholine (PC) from cerebellar neurons differentiated in culture. With "mild" treatment, the loss cell lipids deep reorganization remaining membrane lipids. In fact, amount PC associated Triton X-100-insoluble fraction (highly enriched sphingolipids cholesterol nontreated cells) was lowered by treatment. This suggested reduction lipid domain area. However,...
Abstract Targeted immunotherapy combinations, including the anti-CD38 monoclonal antibody (MoAb) daratumumab, have shown promising results in patients with relapsed/refractory multiple myeloma (RRMM), leading to a considerable increase progression-free survival. However, large fraction of inevitably relapse. To understand this, we investigated 32 relapsed MM treated lenalidomide, and dexamethasone (Dara-Rd; NCT03848676). We conducted an integrated analysis using whole-genome sequencing (WGS)...
Human fibroblasts, rat neurons, and murine neuroblastoma cells, cultured in the presence of fetal calf serum, were fed with [1-(3)H]sphingosine to radiolabel sphingolipids. The fate cell sphingolipids, release sphingolipids culture medium, interaction proteins lipoproteins taken up by cells investigated. For this latter purpose, medium containing radioactive was delivered nonlabeled cells. tritium at position 1 sphingosine allowed us follow extent sphingolipid catabolism measuring production...
Background and purpose Anti‐sulfatide immunoglobulin M (IgM) antibodies have been associated with different forms of neuropathies but their diagnostic role in neuropathy remains unclear. Methods The clinical association increased titers anti‐sulfatide IgM 570 patients related disorders examined our laboratory since 2004 was reviewed. Sera were tested by enzyme‐linked immunosorbent assay at the initial serum dilution 1:32 000 titrated serial two‐fold dilution. In all positive to...
A diagnostic score was developed to discriminate anti-myelin-associated-glycoprotein (MAG) neuropathy from chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and applied it patients with atypical anti-MAG neuropathy.The clinical electrophysiological features of a diagnosis typical were compared those CIDP. The association each feature the assessed in two groups. Features showing significant included multivariable logistic regression model adjusted odds ratios estimated for...
Background To evaluate the efficacy of rituximab in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients not responding to conventional immune therapies. Methods An open-label, prospective exploratory study was conducted with intravenous on 17 CIDP who had responded at least two first-line The primary endpoint determine proportion showed improvement 6 months after therapy. percentage responders rituximab, along a 95% CI, reported and compared 30% response rate other...
Anti-sulfatide antibodies have been observed in heterogeneous neuropathies and their clinical relevance is still controversial. Whether the combination of sulfatide with galactocerebroside would increase sensitivity or specificity enzyme-linked immunosorbent assay testing compared to alone was assessed.Immunoglobulin M (IgM) sulfatides, combined (Sulf/GalC) were measured 229 neuropathy patients, including 73 IgM paraproteinemic [62 anti-myelin-associated glycoprotein (anti-MAG) antibody] 156...
SUMMARY Anti-CD38 antibody therapies have transformed multiple myeloma (MM) treatment. However, a large fraction of patients inevitably relapses. To understand this, we investigated 32 relapsed MM treated with daratumumab, lenalidomide, and dexamethasone (Dara-Rd; NCT03848676 ). Whole genome sequencing (WGS) before after treatment pinpointed genomic drivers associated early progression, including RPL5 loss APOBEC mutagenesis. Flow cytometry on 202 blood samples, collected every three months...