A5017879669- Chemical Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Synthesis of heterocyclic compounds
- Synthesis and Biological Evaluation
- Chemical Synthesis and Reactions
- Organic and Inorganic Chemical Reactions
- Organic Chemistry Cycloaddition Reactions
- Chemical Reactions and Mechanisms
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Synthesis and Reactions of Organic Compounds
- Molecular spectroscopy and chirality
- Phenothiazines and Benzothiazines Synthesis and Activities
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Fluorine in Organic Chemistry
- Coordination Chemistry and Organometallics
- Synthesis and biological activity
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemical Synthesis and Analysis
University of Genoa
2015-2025
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2023
Industriale Chimica (Italy)
1989-2017
Hudson Institute
2017
University of Naples Federico II
2008
Institute for Complex Systems
2006
National Interuniversity Consortium of Materials Science and Technology
2006
University of Bologna
1998-2005
University of Palermo
1991-2002
University of Liverpool
1997
Recently, nitrostilbenes characterized by two different or differently substituted aryl moieties, obtainable from the initial ring-opening of 3-nitrobenzo[b]thiophene with amines, have proved, means a stepwise double coupling phenolic-type bidentate C/O nucleophiles, to be valuable precursors oxygen-containing heteropolycycles and fully conjugated systems therefrom via an efficient 6π-electrocyclization final aromatization. Herein, methodology is extended, after suitable optimization,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13 NMR study on the nature of resonance interactions in 4-substituted benzonitriles, acetophenones, and methyl benzoatesCarlo Dell'Erba, Fernando Sancassan, Marino Novi, Giovanni Petrillo, Angelo Mugnoli, Domenico Spinelli, Consiglio, Paolo GattiCite this: J. Org. Chem. 1988, 53, 15, 3564–3568Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July...
The reversal of multidrug resistance by 22 molecules [8-aryl-8-hydroxy-5-R′-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones (1a−i) and 8-aryl-8-alkoxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones (2a−m)] related to myocardial-calcium-channel-modulator diltiazem was studied in resistant A2780/DX3 their sensitive counterpart A2780 cells. MTT, cytofluorimetry assays, fluorescence microscopy analyses were used define activity accumulation doxorubicin with or without the diltiazem-like...
The title reaction has been studied in dioxane/water a large (0.1-14.9) pS+ range, evidencing, together with an uncatalyzed process at intermediate (3.5-8.0) values, the occurrence of catalyzed pathway both acidic (pS+ 0.1-3.5) and basic region 8.0-14.9): specific-acid catalysis general-base catalysis, respectively, have found to take place by means kinetic investigations different buffer concentrations. Mechanisms for three pathways advanced on grounds structural features. In comparison...
β-Nitrothiophenes undergo a facile ring-opening process when treated with secondary amines in ethanol (in the presence of AgNO 3 , but for 3,4-dinitrothiophene), providing interesting polyfunctionalized linear nitro-or dinitro-butadienic building-blocks, which can be further manipulated and eventually exploited preparation targets various nature.In particular, great variety homo-and hetero-cyclic compounds may obtained some representative results this field, relevant to synthetic,...
4-Alkyl-2-nitrothiophenes [10: R = CH3, CH(OH)CH3, CH(OCH3)CH3] react with secondary aliphatic amines, in the presence of AgNO3, to give 3-alkyl-2-amino-5-nitrothiophenes (12) through an oxidative nucleophilic substitution hydrogen (ONSH) synthetic interest. This behavior is striking contrast that parent 2-nitrothiophene (6), which was found undergo ring-opening analogous reaction conditions. A possible rationale for crucial effect alkyl groups suggested, grounded also on a study...
Abstract Gold and silver nanoparticles of different size, decorated by a diacetylenic monomer having COOH anchor group, were prepared in aqueous dispersions. Topochemical polymerization the colloidal suspensions was obtained UV irradiation studied means spectroscopic techniques (UV–visible absorption, IR Raman spectroscopies). A variety polymer phases found case nanohybrids. The main contribution for this investigation supplied spectra, which provide detailed information on forms preferred...
In prosecution of previous work on the thermal cyclization 1-aryl-4-methanesulfonyl-2-nitro-3-phenylsulfonyl-1,3-butadienes (7), 3-unsubstituted derivatives 8, deriving from initial ring opening 3-nitrothiophene (2), have been likewise found herein to undergo cyclization, followed by aromatization, in analogous mild experimental conditions, leading ring-fused homo- or heteroaromatic nitro 10. The concerted electrocyclic nature process is strongly supported outcome tests based variation...