A5022727716- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Medicinal Plants
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Cholinesterase and Neurodegenerative Diseases
- Diet, Metabolism, and Disease
- Phytochemistry and Bioactivity Studies
- Phytochemicals and Antioxidant Activities
- Enzyme Production and Characterization
- Synthesis and biological activity
- Andrographolide Research and Applications
- Phytochemistry and biological activities of Ficus species
- Diverse Scientific Research Studies
- SARS-CoV-2 and COVID-19 Research
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- COVID-19 Pandemic Impacts
- Plant biochemistry and biosynthesis
- Drug Solubulity and Delivery Systems
- Seaweed-derived Bioactive Compounds
KLE University
2019-2025
Nitte University
2022-2025
Scriptorium
2024
Adamas University
2020
University of Asmara
2020
Ministry of AYUSH
2020
Chosun University
2009-2011
Aim: The purpose of this study was to establish a mode action for diosgenin against breast cancer employing range system biology tools and corroborate its results with experimental facts. Methodology: diosgenin-regulated domains implicated in were enriched the Kyoto Encyclopedia Genes Genomes database diosgenin-protein(s)-pathway(s) associations. Later, molecular docking lead complexes considered dynamics simulations, MMPBSA, principal component, cross-correlation matrix analysis using...
Phenolic constituents of virgin olive oil are reported to have antitumor activity. However, the underlying molecular mechanisms and specific target proteins remain be elucidated. Here, we report that dialdehydic form decarboxymethyl ligstroside aglycone ( p -HPEA-EDA), a phenolic compound oil, inhibits tumor promoter-induced cell transformation in JB6 Cl41 cells suppress cyclooxygenase-2 (COX-2) tumorigenicity by adenosine monophosphate-activated protein kinase (AMPK) activation HT-29 cells....
Abstract Background Tinospora cordifolia is used traditionally for the treatment of diabetes and in various formulations. Scientific evidence also available its anti-diabetic potency under animal models. However, probable molecular mechanism has not been illuminated yet. Hence, present study dealt to elucidate effect using network pharmacology approach. Methods The structural information bioactive phytoconstituents was retrieved from different open source databases. Compounds were then...
Abstract Anthraquinone derivatives are identified for their immune-boosting, anti-inflammatory, and anti-viral efficacy. Hence, the present study aimed to investigate reported anthraquinone as immune booster molecules in COVID-19 infection evaluate binding affinity with three targets of novel coronavirus i.e. 3C-like protease, papain-like spike protein. The were retrieved from an open-source database filtered based on a positive druglikeness score. Compounds scores predicted using DIGEP-Pred...
Bioflavonoids are the largest group of plant-derived polyphenolic compounds with diverse biological potential and have also been proven efficacious in treatment Severe Acute Respiratory Syndrome (SARS) Middle East (MERS). The present investigation validates molecular docking, simulation, MM-PBSA studies fifteen bioactive bioflavonoids derived from plants as a plausible antiviral COVID-19. Molecular docking for 15 flavonoids on three SARS CoV-2 proteins, non-structural protein-15...
Traditionally, Withania somnifera is widely used as an immune booster, anti-viral, and for multiple medicinal purposes. The present study investigated the withanolides booster anti-viral agents against coronavirus-19. Withanolides from were retrieved open-source database, their targets predicted using DIGEP-Pred, protein-protein interaction was evaluated. drug-likeness score intestinal absorptivity of each compound also predicted. network compounds, proteins, modulated pathways constructed...
The present study aimed to investigate the binding affinity of andrographolide and its derivative i.e., 14-deoxy-11,12-didehydroandrographolide with targets related COVID-19 their probable role in regulating multiple pathways infection. SMILES both compounds were retrieved from PubChem database predicted for probably regulated proteins. proteins queried STRING evaluate protein-protein interaction, modulated identified concerning KEGG database. Drug-likeness ADMET profile each compound was...
Objective: To identify alpha-glucosidase inhibitors from Ficus benghalensis and analyze gene set enrichment of regulated protein molecules.Methods: The phytoconstituents were queried for alpha-glucosidase, also identified as aldose reductase inhibitors. Druglikeness score, absorption, distribution, metabolism, excretion toxicity profile, biological spectrum, expression predicated each compound. Docking study was performed to predict the binding affinity with compared clinically proven...
The Ministry of AYUSH recommended the use a decoction mixture Ocimum tenuiflorum, Cinnamomum verum, Piper nigrum, Zingiber officinale, and Vitis vinifera as preventive measure by boosting immunity against severity infection caused novel coronavirus (COVID-19). present study aimed to identify probable modulated pathways combined action herbal tea golden milk formulation an immune booster COVID-19. Reported phytoconstituents all medicinal plants were retrieved from ChEBI database, their...
(1) Background: The monkeypox virus is a zoonotic orthopox DNA that closely linked to the virus. In light of growing concern about this virus, current research set out use bioinformatics and immunoinformatics develop potential vaccine against (2) Methods: A multiepitope was constructed from B-cell T-cell epitopes MPXVgp181 strain using adjuvant different linkers. predicted for antigenicity, allergenicity, toxicity, population coverage. silico immune simulation studies were also carried out....
Transient receptor potential vanilloid 3 (TRPV3) is a thermosensitive calcium-permeable ion channel and has function in sensory perception, epidermal barrier function, inflammation keratinocyte proliferation. TRPV3 dysfunction linked with chronic pain, atopic dermatitis neurodegenerative disorders. This study compared the binding efficacy molecular dynamics of cannabidiol- eugenol-TRPV3 complex(s), elucidating their ligand-protein dynamics. Computational methods, including density functional...
To report in vitro anti-oxidant activity and cytotoxicity of hydroalcoholic extract Ficus benghalensis (bark) Duranta repens (whole plant), present the probable biological spectrum major anti-oxidants from both plants.The coarse powder plants was first extracted with 70% ethanol (maceration) followed by 99% (Soxhlet-extraction). Anti-oxidant extracts evaluated using DPPH, H2O2, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), NO scavenging assay, total antioxidant capacity,...
Cassia glauca is reported for anti-diabetic action and also used as an ethnomedicine.
Cisplatin resistance is one of the major contributors to poor survival rate among head and neck cancer (HNC) patients. Focusing on protein-protein interaction rather than a single protein could provide better understanding drug resistance. Thus, this study aimed identify hub genes in complex network cisplatin associated HNC chemotherapy via series bioinformatic tools.The involved were retrieved from NCBI gene database using "head cancer" "cisplatin resistance" as key words. The human...
Melanoma,also known as a 'black tumor', begins in the melanocytes when cells (that produce pigment) grows out of control. Immunological dysregulation, which raises risk for multiple illnesses, including melanoma, may be influenced by stress tiggered through viral infection, long term effects ultraviolet radiation, environmental pollutants etc. Borapetoside C is one phytoconstituents from Tinospora crispa, and its biological source has been reported antistress property. Network pharmacology...
Inflammatory conditions elicited by extrinsic environmental factors promote malignant transformation, tumor growth and metastasis. Although the role of T cells in cancer promotion has been examined, little is known about underlying molecular mechanisms interleukin-17 A (IL-17A), a proinflammatory cytokine produced activated CD4 + memory cells, carcinogenesis. Here, we report that IL-17A induces neoplastic transformation JB6 Cl41 through activation progression locus 2 (TPL2). dose-...