Abstract Background Tinospora cordifolia is used traditionally for the treatment of diabetes and in various formulations. Scientific evidence also available its anti-diabetic potency under animal models. However, probable molecular mechanism has not been illuminated yet. Hence, present study dealt to elucidate effect using network pharmacology approach. Methods The structural information bioactive phytoconstituents was retrieved from different open source databases. Compounds were then...

Bioflavonoids are the largest group of plant-derived polyphenolic compounds with diverse biological potential and have also been proven efficacious in treatment Severe Acute Respiratory Syndrome (SARS) Middle East (MERS). The present investigation validates molecular docking, simulation, MM-PBSA studies fifteen bioactive bioflavonoids derived from plants as a plausible antiviral COVID-19. Molecular docking for 15 flavonoids on three SARS CoV-2 proteins, non-structural protein-15...

Traditionally, Withania somnifera is widely used as an immune booster, anti-viral, and for multiple medicinal purposes. The present study investigated the withanolides booster anti-viral agents against coronavirus-19. Withanolides from were retrieved open-source database, their targets predicted using DIGEP-Pred, protein-protein interaction was evaluated. drug-likeness score intestinal absorptivity of each compound also predicted. network compounds, proteins, modulated pathways constructed...

The present study aimed to investigate the binding affinity of andrographolide and its derivative i.e., 14-deoxy-11,12-didehydroandrographolide with targets related COVID-19 their probable role in regulating multiple pathways infection. SMILES both compounds were retrieved from PubChem database predicted for probably regulated proteins. proteins queried STRING evaluate protein-protein interaction, modulated identified concerning KEGG database. Drug-likeness ADMET profile each compound was...

The Ministry of AYUSH recommended the use a decoction mixture Ocimum tenuiflorum, Cinnamomum verum, Piper nigrum, Zingiber officinale, and Vitis vinifera as preventive measure by boosting immunity against severity infection caused novel coronavirus (COVID-19). present study aimed to identify probable modulated pathways combined action herbal tea golden milk formulation an immune booster COVID-19. Reported phytoconstituents all medicinal plants were retrieved from ChEBI database, their...

The decoction of the whole plant Enhydra fluctuans is used ethno medicinally by various tribes for treatment kidney stones and urinary problems. However, no scientific studies were carried out to delineate its influence on stone formation crystallisation. Hence, present study proposed investigate effect aqueous extract in vitro crystallisation calcium oxalate. also evaluated. silico metabolites with target proteins renal oxalate matrix. material was subjected obtain an extract....

The endocannabinoid system consists of several phytocannabinoids, cannabinoid receptors, and enzymes that aid in numerous steps necessary to manifest any pharmacological activity. It is well known the inhibits pathogenesis inflammatory autoimmune disease rheumatoid arthritis (RA). To best our knowledge, no research has been done explains network-pharmacology-based anti-rheumatic processes by focusing on system. Therefore, purpose this study further understanding signaling pathways,...

Chandraprabha vati is a classical Ayurvedic formulation, markedly used for mitigation of Prameha, which correlates in many ways with obesity, metabolic syndrome and diabetes mellitus.The present study was aimed to investigate effect experimentally-induced hyperglycemia lipid profile alterations.Antidiabetic studied fifty five Wistar rats. Graded doses (50, 100 200 mg/kg) were administered orally 7 days normal alloxan-hyperglycemic rats (65 mg/kg, intravenously), glucose loaded oral tolerance...

The tuber of Amorphophallus paeoniifolius (Dennst.) Nicolson (Araceae), commonly called Suran or Jimmikand, has high medicinal value and is used ethnomedicinally for the treatment different gastrointestinal inflammatory disorders.The present study evaluated effects extracts tubers on acetic acid-induced ulcerative colitis (UC) in rats.Wistar rats were orally administered methanol extract (APME) aqueous (APAE) (250 500 mg/kg) standard drug, prednisolone (PRDS) (4 7 days. On 6th day treatment,...

Aim: The present study aimed to investigate huperzine A as an anti-Alzheimer agent based on the principle that a single compound can regulate multiple proteins and associated pathways, using system biology tools. Methodology: simplified molecular-input line-entry of was retrieved from PubChem database, its targets were predicted SwissTargetPrediction. These matched with deposited in DisGeNET for Alzheimer disease enriched STRING identify probably regulated cellular components, biological...

Andrographis paniculata [Burm. F] Nees is a potent drug used in Ayurveda, Siddha and Homoeopathy many formulations effective the treatment of various diseases like malaria, diabetes, viral hepatitis, cirrhosis, liver cancer, etc. For long-term use these conditions, establishment safety any given intervention crucial. Hence present review journals, e-books, monographs, books, data base on medicinal plant, from 1986 to 2010 Ayurvedic classical text/ earliest literature Indian Medicine Charaka...

Abstract Background Stem bark of Anogeissus latifolia Roxb (family: Combretaceae) is used traditionally and ethnomedicinally to alleviate pain, inflammation fever conditions. The current study investigates the analgesic, anti-inflammatory antipyretic activities ethanolic extract stem Roxb. Method HPLC studies were carried out standardize (ALEE) using ellagic acid as a marker. ALEE was screened for analgesic (formalin-induced pain acetic induced writhing) (formalin carrageenan-induced paw...

Aim:The tuber of Amorphophallus paeoniifolius (Family-Araceae), commonly called suran or jimikand, has medicinal and food value.It is used in ethnomedicinal practices for correction gastrointestinal disturbances such as constipation hemorrhoids.The present study evaluated the effect A. on motor functions.Materials Methods: The was collected December 2011, its methanolic extract standardized with major phenolic compound, betulinic acid, by high-performance liquid chromatography.Rats were...

The leaves of Chenopodium album Linn. are traditionally used for treatment kidney diseases and urinary stones. present work investigated the effect aqueous extract C. (CAAE) on in-vitro crystallization CaOx brushite crystals. Crystallization was studied by using nucleation aggregation assay calcium oxalate (CaOx) crystals growth monohydrate effects CAAE cystone slope as well were evaluated spectrophotometrically. densities formed compared under microscope. citric acid single diffusion gel...

Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.

Background: Trayodashang guggulu (TG) is a compound Ayurvedic formulation used in Indian traditional system of medicine for the treatment various inflammatory conditions like arthritis and associated pain. Purpose:To study analgesic anti-inflammatory effects trayodashang guggulu. Methods: was standardized as per standard procedures TLC profile carried Pharmacopoeia India LC-MS analysis done to identify its bioactive constituents. suspended water administered orally at 270 540 mg/kg dose...