A5010487091- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Injury Epidemiology and Prevention
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Healthcare Operations and Scheduling Optimization
- HIV/AIDS drug development and treatment
- Simulation Techniques and Applications
- Trauma and Emergency Care Studies
- Pharmaceutical Economics and Policy
- Statistical Methods in Clinical Trials
- Obesity, Physical Activity, Diet
- Healthcare cost, quality, practices
- Social Policy and Reform Studies
- demographic modeling and climate adaptation
- Research in Social Sciences
- Pneumonia and Respiratory Infections
- Homicide, Infanticide, and Child Abuse
- Urbanization and City Planning
- Cardiac pacing and defibrillation studies
- Bacterial Infections and Vaccines
- Orthopaedic implants and arthroplasty
- Quality and Safety in Healthcare
- Traffic and Road Safety
- Health Policy Implementation Science
University of Maryland, College Park
2021
EVRAZ (United Kingdom)
2015-2021
University of York
2021
System Simulation (United Kingdom)
2017
McGill University
2008-2017
Ithaka Harbors
2013-2017
Lund University
2014-2016
United BioSource Corporation (United Kingdom)
2011-2013
The University of Adelaide
1991-2012
Harvard University
2012
Discrete event simulation (DES) is a form of computer-based modeling that provides an intuitive and flexible approach to representing complex systems. It has been used in wide range health care applications. Most early applications involved analyses systems with constrained resources, where the general aim was improve organization delivered services. More recently, DES increasingly applied evaluate specific technologies context technology assessment. The this article provide consensus-based...
Two mixing methods, hand and vacuum mixing, were compared using high viscosity, molecular, antibiotic containing polymethylmethacrylate kept at two different temperatures, 4 degrees C 21 C, prior to mixing. The mechanical properties, i.e., fracture strength, maximum deflection, modulus of elasticity hardness, improved by when with both temperatures. fatigue life was 10 times longer after Chilling made the easier handling characteristics. Vacuum delayed setting time 1 minute, but also...
The mechanical strength of high and low viscosity gentamicin-containing cement was analysed using three different mixing procedures: hand, vibration, vacuum stirring.Vacuum improved the flexural compression modulus elasticity by 15–30 per cent, especially for cement.
After the first year of life, injury is leading cause mortality in children and adolescents Australia a major morbidity hospitalization. Studies from Europe North American more recently New Zealand have demonstrated that rates differ between different socio-economic groups, with relatively consistent pattern higher being found lower groups. To date, child by group has not been studied Australia. Eighteen months data Brisbane Melbourne collections National Injury Surveillance Unit base were...
Smoking cessation medications have been shown to yield higher success rates and sustained abstinence than unassisted quit attempts. In Japan, the treatments available include nicotine replacement therapy (NRT) varenicline; however, attempts smoking remain common. The objective of this study was compare health economic consequences in Japan using pharmacotherapy support with current mix strategies used. A discrete-event simulation that models lifetime quitting behaviour includes multiple...
Objective:To estimate the cost-effectiveness (cost per additional life-year [LY] and quality-adjusted [QALY] gained) of lenalidomide plus dexamethasone (LEN/DEX) compared with bortezomib for treatment relapsed-refractory multiple myeloma (rrMM) in Norway.Methods:A discrete-event simulation model was developed to predict patients’ disease course using patient data, best response, efficacy levels obtained from LEN/DEX MM-009/-010 trials (APEX) published clinical trial. Predictive equations...
Meningococcal disease can have devastating consequences. As new vaccines emerge, it is necessary to assess their impact on public health. In the absence of long-term real world data, modeling effects different vaccination strategies required. Discrete event simulation provides a flexible platform with which conduct such evaluations. A discrete epidemiology invasive meningococcal was developed quantify potential implementing routine adolescents in United States quadrivalent conjugate vaccine...
In schizophrenia, medication adherence is critical to achieve better patient outcomes and avoid relapses, which are responsible for a significant proportion of total healthcare costs this chronic illness. The aim study was assess the cost-effectiveness olanzapine long-acting injection (OLAI) compared with risperidone (RLAI) in patients schizophrenia Spain. A discrete event simulation (DES) model developed from Spanish system perspective estimate clinical economic over five-year period....
Objective This study sought to estimate the economic implications of managing bradycardia due sinoatrial node disease or atrioventricular block with dual compared single-chamber ventricular pacemakers from an Italian government perspective. Dual-chamber lower risk developing atrial fibrillation and pacemaker syndrome. Methods A discrete event simulation a patient's course for 5 years following implantation. Each patient may experience following: complications, syndrome, fibrillation, stroke,...
Aims To estimate the consequences of managing bradycardia due to sinoatrial node disease or atrioventricular block with dual-chamber vs. single-chamber ventricular pacemakers. Methods and results A discrete-event simulation was conducted predict outcomes over 5 years. Patients could develop post-operative complications, clinically relevant pacemaker syndrome leading replacement dual-chamber, atrial fibrillation (AF; which if chronic might require anticoagulants) stroke. Survival,...
The global prevalence of obesity is rising rapidly, highlighting the importance understanding risk factors related to condition. Childhood obesity, which has itself become increasingly prevalent, an important predictor adulthood obesity. Studies suggest that protein content consumed in infanthood weight gain childhood, may contribute higher body mass index (BMI). For instance, there evidence a lower infant formula (lpIF) for infants overweight or obese mothers can offer advantages over...