A5017043744- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Diabetes Management and Research
- Cardiac pacing and defibrillation studies
- RNA modifications and cancer
- Cardiac Arrhythmias and Treatments
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Parkinson's Disease Mechanisms and Treatments
- Pharmaceutical Economics and Policy
- Atrial Fibrillation Management and Outcomes
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Smoking Behavior and Cessation
- Venous Thromboembolism Diagnosis and Management
- Pharmaceutical Practices and Patient Outcomes
- Schizophrenia research and treatment
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Pharmaceutical studies and practices
Ithaka Harbors
2013-2023
University of Liverpool
2020
Thomas Jefferson University Hospital
2018
Sidney Kimmel Cancer Center
2018
Group Image (Poland)
2018
Amgen (United States)
2017
Royal United Hospital
2013-2014
Lexington City Schools
2012
West Chester University
2012
United BioSource Corporation (United Kingdom)
2009-2011
The experimental evolution of laboratory populations microbes provides an opportunity to observe the evolutionary dynamics adaptation in real time. Until very recently, however, such studies have been limited by our inability systematically find mutations evolved organisms. We overcome this limitation using a variety DNA microarray-based techniques characterize genetic changes—including point mutations, structural changes, and insertion variation—that resulted from 24 haploid diploid...
OBJECTIVE—To model the lifetime costs associated with complications of type 2 diabetes. RESEARCH DESIGN AND METHODS—A cohort 10,000 patients diabetes was simulated using a based on existing epidemiological studies. Complication rates were estimated for various stages macrovascular disease, nephropathy, retinopathy, neuropathy, and hypoglycemia. At beginning simulation, assumed to have been treated 5 years mean HbA1c 8.4. From U.K. Prospective Diabetes Study, it that current therapies, would...
Pancreatic atrophy is common in longstanding type 1 diabetes, but there are limited data concerning pancreas size at diagnosis. Our objective was to determine whether pancreatic reduced patients with recently diagnosed diabetes and assess volume related residual β-cell function or islet autoantibodies. We conducted a controlled cohort study strict inclusion criteria, recruiting from hospital clinics between 2007 2010. Participants included 20 male adult (median age 27 yr) recent-onset...
Article AbstractBackground: The relative risk of diabetes among patients undergoing risperidone treatment was compared with that receiving olanzapine. Method: A cohort formed 33,946 at least 1 prescription for either olanzapine (N=19,153) or (N=14,793) between January 1, 1997, and December 31, 1999, recorded in the Regie de l'Assurance Maladie du Quebec database. Patients were excluded if clozapine dispensed to them during study period they diagnosed before beginning antipsychotic therapy....
The purpose of this study was to determine the direct medical US cost managing multiple sclerosis relapses. Direct data analysis and modeling were employed derive typical resource use profiles costs in 2002 dollars, from perspective a third-party payer responsible for comprehensive health-care. location scope health care services provided over 90-day period used define three levels relapse management. Hospitalization resulting subsequent defined as high intensity A medium level intervention...
To describe the burden of thalassemia major and its treatment, in terms prevalence iron-overload-related complications, direct indirect costs, patient's physical social well-being.From October 1999 to May 2000 a survey patients with was conducted ten countries: Cyprus, Egypt, Greece, Hong Kong, India, Iran, Italy, Jordan, Taiwan, United States.1,888 questionnaires (65%) were returned. The responses suggest that nowadays begin blood transfusions, most use desferrioxamine (84.8%), but...
Abstract Background: Bordetella pertussis is highly contagious, and because immunity wanes after vaccination, it continues to be a cause of cough among adults. Objective: To describe the healthcare services used productivity losses accrued by workers (HCWs) missing work due pertussis. Methods: After 3 cases were confirmed HCWs, all hospital employees patients with screened between November 2000 March 2001. Each potential case underwent diagnostic tests received antibiotics (spiramycin or...
<b><i><i>Objective:</i></i></b> To develop a framework for estimating the long-term health and economic consequences of AD based on patient characteristics at given point in time. <b><i><i>Methods:</i></i></b> A pharmacoeconomic model (Assessment Health Economics Alzheimer's Disease, AHEAD) was developed equations that relate probability needing full-time care (FTC) over time to summarized index scores. These were from published data interquartile times until FTC is needed death, using...
The use of DNA microarrays to identify nucleotide variation is almost 20 years old. A variety improvements in probe design and experimental conditions have brought this technology the point that single-nucleotide differences can be efficiently detected unmixed samples, although developing reliable methods for detection mixed sequences (e.g., heterozygotes) remains challenging. Surprisingly, a comprehensive study parameters optimize discrimination polymorphisms (SNPs) has yet reported, so...
Smoking cessation medications have been shown to yield higher success rates and sustained abstinence than unassisted quit attempts. In Japan, the treatments available include nicotine replacement therapy (NRT) varenicline; however, attempts smoking remain common. The objective of this study was compare health economic consequences in Japan using pharmacotherapy support with current mix strategies used. A discrete-event simulation that models lifetime quitting behaviour includes multiple...
Lumacaftor/ivacaftor combination therapy is efficacious and generally safe for patients with cystic fibrosis (CF) homozygous the F508del-CF transmembrane conductance regulator (CFTR) mutation. However, long-term survival benefits of lumacaftor/ivacaftor (LUM/IVA) cannot yet be quantified. Simulation models can provide predictions about health outcomes. In this study, we aimed to project outcomes LUM/IVA plus standard care (SC) in CF F508del-CFTR.
Patients with Alzheimer's disease experience a progressive loss of cognitive function, and the ability to independently perform activities daily life. Sometimes dependent stage is reached quite early in disease, when caregivers decide that patients can no longer be left alone safely. This an important aspect for patients, their families, also health care providers. Understanding relationship between patient's current status need may assist clinicians recommending appropriate management plan....
The economic impact of dementia on the Dutch health and social services is substantial.To predict long-term galantamine, a cholinesterase inhibitor, in treatment patients with mild to moderate Alzheimer's disease.A pharmacoeconomic model was used outcomes. It has two components: an initial module based clinical trials galantamine subsequent that predicts when patient will deteriorate level where full time care (FTC) needed. analyses take broad perspective includes all formal (paid) care, not...
Early diagnosis of the rare and life-threatening uterine leiomyosarcoma (LMS) is essential for prompt treatment, to improve survival. Preoperative distinction LMS from benign leiomyoma remains a challenge, thus often diagnosed post-operatively. This retrospective observational study evaluated predictive diagnostic utility 32 preoperative variables in 190 women who underwent hysterectomy, with postoperative (n = 159) or 31), at Liverpool Women’s National Health Service (NHS) Foundation Trust,...