A5018294391- Genetic Mapping and Diversity in Plants and Animals
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Smoking Behavior and Cessation
- Chronic Myeloid Leukemia Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Air Quality and Health Impacts
- Inflammatory Myopathies and Dermatomyositis
- Birth, Development, and Health
- AI in cancer detection
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Genetics, Aging, and Longevity in Model Organisms
- Healthcare Systems and Practices
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Plant and fungal interactions
- Genomics and Phylogenetic Studies
- Medication Adherence and Compliance
- Schizophrenia research and treatment
- Immune Cell Function and Interaction
- Artificial Intelligence in Healthcare
- Genetic Syndromes and Imprinting
- Statistical and numerical algorithms
- Mitochondrial Function and Pathology
Harvard University
2024
University of North Carolina at Chapel Hill
2015-2024
Pediatrics and Genetics
2022
St. Vincent's Medical Center
2021
Hartford Financial Services (United States)
2021
United BioSource Corporation (United Kingdom)
2011
Background The objectives of this study were to develop and test in real-world clinical practice the effectiveness a comprehensive postacute stroke transitional care (TC) management program. Methods Results COMPASS (Comprehensive Post-Acute Stroke Services) was pragmatic cluster-randomized trial where hospital unit randomization. intervention (COMPASS-TC) initiated at 20 hospitals, hospitals provided their usual care. Hospital staff enrolled 6024 adult transient ischemic attack patients...
Abstract Background The COMprehensive Post-Acute Stroke Services (COMPASS) pragmatic trial compared the effectiveness of comprehensive transitional care (COMPASS-TC) versus usual among stroke and transient ischemic attack (TIA) patients discharged home from North Carolina hospitals. We evaluated implementation COMPASS-TC in 20 hospitals randomized to intervention using RE-AIM framework. Methods hospital-level Adoption COMPASS-TC; patient Reach (meeting management requirements timely...
Traumatic brain injury (TBI) is a complex and heterogeneous condition that can cause wide-spectral neurological sequelae such as behavioral deficits, sleep abnormalities, post-traumatic epilepsy (PTE). However, understanding the interaction of TBI phenome challenging because few animal models recapitulate heterogeneity outcomes. We leveraged genetically diverse recombinant inbred Collaborative Cross (CC) mice panel systematically characterized TBI-related outcomes in males from 12 strains CC...
Increased toxicities have been identified with higher doses of pegaspargase (PEG-ASP) in adults. This has led to routine use a dose cap 3,750 IU for adult acute lymphoblastic leukemia (ALL) patients most institutions. In pediatric ALL patients, PEG-ASP is not capped. There concern at our institution that larger may result increased rates adverse effects and monitoring be warranted receiving greater than IU. The objective this study quantify the difference PEG-ASP-associated events between...
Abstract Objective SCN8A encephalopathy is a developmental epileptic typically caused by de novo gain‐of‐function mutations in Na v 1.6. Severely affected individuals exhibit refractory seizures, delay, cognitive disabilities, movement disorders, and elevated risk of sudden death. Patients with the identical variant can differ clinical course, suggesting role for modifier genes determining disease severity. The identification genetic modifiers contributes to understanding pathogenesis...
Objective: To present a tool that allows estimation of the budget impact treatments for acute mania in bipolar I disorder from US healthcare payer perspective.Methods: Using discrete event simulation, course individuals is simulated beginning with hospitalization. Discharge depends on symptom level measured by Young Mania Rating Scale (YMRS). The treatment effect determined using time-dependent regression equations derived trial data, and decision rules obtained clinical experts. Outcomes...
Collateral blood flow varies greatly among humans for reasons that remain unclear, resulting in significant differences ischemic tissue damage. A similarly large variation has also been found mice is caused by genetic background-dependent the extent of collateral formation, termed collaterogenesis-a unique angiogenic process occurs during development and determines number diameter adult. Previous studies have identified several quantitative trait loci (QTL) linked to this variation. However,...
Schizophrenia is an idiopathic disorder that affects approximately 1% of the human population, and presents with persistent delusions, hallucinations, disorganized behaviors. Antipsychotics are standard pharmacological treatment for schizophrenia, but frequently discontinued by patients due to inefficacy and/or side effects. Chronic typical antipsychotic haloperidol causes tardive dyskinesia (TD), which manifests as involuntary often irreversible orofacial movements in around 30% patients....
The COMprehensive Post-Acute Stroke Services study was a cluster-randomized pragmatic trial designed to evaluate comprehensive care transitions model versus usual care. data collected during this were complex and analysis methodology required that could simultaneously account for the design, missing patient-level covariates, outcome nonresponse, substantial nonadherence intervention.The objective of discuss an array complementary statistical methods treatment effectiveness appropriately...
To understand the patient-influenced activities and characteristics associated with return to a single postacute care transitional clinic visit in cohort of patients cared for at test health system site larger Comprehensive Post-Acute Stroke Services (COMPASS) cluster randomized trial.Retrospective cohort.A large system.Patients discharged directly home between June 2016 2018 after sustaining stroke who did not receive formal inpatient rehabilitation services while being comprehensive...
Variation in immune homeostasis, the state which system is maintained absence of stimulation, highly variable across populations. This variation attributed to both genetic and environmental factors. However, identity function specific regulators have been difficult identify humans. We evaluated homeostatic antibody levels serum Collaborative Cross (CC) mouse reference population. found heritable all isotypes subtypes measured. identified 4 quantitative trait loci (QTL) associated with 3 IgG...
Abstract Many human diseases result from a complex interplay of behavioral, clinical, and molecular factors. Integrating low-dimensional behavioral clinical features with high-dimensional profiles can significantly improve disease outcome prediction diagnosis. However, while some biomarkers are crucial, many lack informative value. To enhance accuracy understand mechanisms, it is essential to integrate relevant identify key biomarkers, separating meaningful data noise modeling associations....
Semi-continuous data frequently arise in clinical practice. For example, while many surgical patients suffer from varying degrees of acute postoperative pain (POP) post surgery (i.e., POP score > 0), others experience none = indicating the existence two distinct processes at play. Existing parametric or semi-parametric two-part modeling methods for this type semicontinuous can fail to appropriately model these underlying as such rely heavily on (generalized) linear additive assumptions....
ABSTRACT Schizophrenia is an idiopathic disorder that affects approximately 1% of the human population, and presents with persistent delusions, hallucinations, disorganized behaviors. Antipsychotics are standard pharmacological treatment for schizophrenia, but frequently discontinued by patients due to inefficacy and/or side effects. Chronic typical antipsychotic haloperidol causes tardive dyskinesia (TD), which manifests as involuntary often irreversible orofacial movements in around 30%...