A5031909028- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Cardiovascular Issues in Pregnancy
- Pneumonia and Respiratory Infections
- Renal Transplantation Outcomes and Treatments
- Vascular Anomalies and Treatments
- Antibiotic Resistance in Bacteria
- Organ Transplantation Techniques and Outcomes
- Peripheral Artery Disease Management
- Antibiotics Pharmacokinetics and Efficacy
- Vascular Procedures and Complications
- Congenital Heart Disease Studies
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Nematode management and characterization studies
- Immunodeficiency and Autoimmune Disorders
- Dysphagia Assessment and Management
University of Wisconsin–Madison
2024-2025
University of Utah
2015-2024
Primary Children's Hospital
2022-2024
University of Washington
2023
Lenox Hill Hospital
2023
University of Liverpool
2023
Quantitative BioSciences
2020
Intermountain Healthcare
2001-2012
Allegheny General Hospital
2010
Columbia University
2010
Background— Factors that determine survival in pulmonary arterial hypertension (PAH) drive clinical management. A quantitative prediction tool has not been established for research or use. Methods and Results— Data from 2716 patients with PAH enrolled consecutively the US Registry to Evaluate Early Long-Term Disease Management (REVEAL) were analyzed assess predictors of 1-year survival. We identified independent prognosticators derived a multivariable, weighted risk formula One-year date...
The objective of this study was to create a 5-year survivorship model identify key clinical features cystic fibrosis. Such could help researchers and clinicians evaluate therapies, improve the design prospective studies, monitor practice patterns, counsel individual patients, determine best candidates for lung transplantation. authors used information from Cystic Fibrosis Foundation Patient Registry (CFFPR), which has collected longitudinal data on approximately 90% fibrosis patients...
Diesel exhaust particles (DEPs) are major air pollutants that lead to numerous human disorders, especially pulmonary diseases, partly through the induction of oxidative stress. Resveratrol is a polyphenol ameliorates production reactive oxygen species (ROS) and delays aging-related processes. Herein we studied cytoprotective effect resveratrol on DEP-exposed lung cells in factorial experimental design. This work investigates biophysical features including cellular compositions biomechanical...
OBJECTIVE Cystic fibrosis–related diabetes (CFRD) without fasting hyperglycemia (CFRD FH−) is not associated with microvascular or macrovascular complications, leading to controversy about the need for treatment. The Fibrosis Related Diabetes Therapy (CFRDT) Trial sought determine whether therapy improves BMI in these patients. RESEARCH DESIGN AND METHODS A three-arm multicenter randomized trial compared 1 year of premeal insulin aspart, repaglinide, oral placebo subjects cystic fibrosis who...
The effects of lung transplantation on the survival and quality life in children with cystic fibrosis are uncertain.
Patients with cystic fibrosis (CF) are the second largest group of lung transplant recipients in United States. The survival effect transplantation on a general CF population has not previously been measured.To determine impact bilateral patients CF.Retrospective observational cohort study 11 630 who did undergo (controls) and 468 from 115 centers States, 1992-1998. were stratified into 5 groups based 5-year prediction model (survival 1: <30%; 2: 30 to <50%; 3-5: 50 <100%.)Five-year date...
Lung transplantation in cystic fibrosis may improve survival for patients with low 5-year predicted survival. Identifying characteristics that affect post-transplantation patient selection and benefit. Using Cystic Fibrosis Foundation Patient Registry United Network Organ Sharing data, we identified 845 lung transplant recipients from 1991-2001, 12,826 control 1997. We used Cox proportional hazards models to identify variables influence To estimate the benefit of affected by variables,...
Abstract Background Aztreonam lysine for inhalation (AZLI) is being developed treatment of CF patients with Pseudomonas aeruginosa airway infection. Methods This double‐blind, randomized, placebo‐controlled Phase 2 study evaluated the safety, tolerability and efficacy 75 225 mg AZLI administered BID 14 days using eFlow® Electronic Nebulizer (Pari Innovative Manufacturers, Inc., Midlothian, VA). Patients were 13 years older FEV 1 ≥ 40% predicted, chronic P. infection, had used no...
Section:ChooseTop of pageAbstract <<Lung Transplantation for ...Pediatric Lung Transplant...Operative and Perioperati...(Non)-Adherence in Cystic...The Importance Measuri...Three Sociohistorical Cha...Alternate Models Selec...Some Comments on Study De...Lung ...ReferencesCITING ARTICLES
Abstract Background Cystic fibrosis (CF) is caused by CF transmembrane conductance regulator (CFTR) gene mutations producing dysfunctional CFTR proteins leading to progressive clinical disease. Elexacaftor‐tezacaftor‐ivacaftor (ETI) remarkably improves lung disease but associated with substantial weight gain. Study Design and Methods We performed a single‐center longitudinal study predicting 6‐month gain after ETI initiation. used linear mixed effects modeling (LME) determine association of...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonisotropic Enzyme-Inhibitor Interactions: A Novel Nonoxidative Mechanism for Quantum Proteolysis by Human NeutrophilsTheodore G. Liou and Edward J. CampbellCite this: Biochemistry 1995, 34, 49, 16171–16177Publication Date (Print):December 12, 1995Publication History Published online1 May 2002Published inissue 12 December 1995https://doi.org/10.1021/bi00049a032RIGHTS & PERMISSIONSArticle Views154Altmetric-Citations75LEARN ABOUT THESE...
Proteinase inhibitors confine the activity of proteolytic enzymes inflammatory cells, but fail to protect substrates in immediate pericellular zone. We report quantitative imaging that demonstrates discrete, evanescent, quantized events attributable release single azurophil granules from neutrophils. The images provide information about dynamics this nonequilibrium system, which is characterized by overwhelmingly high local concentrations rapidly dissipate. With physiologic extracellular...
Lung function, acute pulmonary exacerbations (APE), and weight are the best clinical predictors of survival in cystic fibrosis (CF); however, underlying mechanisms incompletely understood. Biomarkers current disease state predictive future outcomes might identify provide treatment targets, trial endpoints objective monitoring tools. Such CF-specific biomarkers have previously been elusive. Using observational validation cohorts comprising 97 non-transplanted consecutively-recruited adult CF...