A5081624710- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Pulmonary Hypertension Research and Treatments
- Cystic Fibrosis Research Advances
- Respiratory viral infections research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Vascular Anomalies and Treatments
- Cytomegalovirus and herpesvirus research
- Organ and Tissue Transplantation Research
- Actinomycetales infections and treatment
- Mechanical Circulatory Support Devices
- Nitric Oxide and Endothelin Effects
- Antifungal resistance and susceptibility
- Vascular Malformations and Hemangiomas
- Esophageal and GI Pathology
- Foreign Body Medical Cases
- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Cardiovascular and Diving-Related Complications
- SARS-CoV-2 and COVID-19 Research
- Sharing Economy and Platforms
- Mast cells and histamine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of Utah
2015-2025
University of Utah Hospital
2023
United States Department of Health and Human Services
2004
National Institute of Allergy and Infectious Diseases
2004
National Center for Infectious Diseases
2004
National Institutes of Health
2004
Centers for Disease Control and Prevention
2004
American Type Culture Collection
2004
Intermountain Healthcare
2002
Pulmonary Associates
2001
The objective of this study was to create a 5-year survivorship model identify key clinical features cystic fibrosis. Such could help researchers and clinicians evaluate therapies, improve the design prospective studies, monitor practice patterns, counsel individual patients, determine best candidates for lung transplantation. authors used information from Cystic Fibrosis Foundation Patient Registry (CFFPR), which has collected longitudinal data on approximately 90% fibrosis patients...
Transforming growth factor-beta1 (TGF-beta1) is abundantly expressed in pulmonary hypertension, but its effect on the circulation remains unsettled. We studied consequences of TGF-beta1 stimulation freshly isolated human artery smooth muscle cells (HPASMC). initially promoted differentiation, with upregulated expression contractile proteins. also induced Nox4, only NAD(P)H oxidase membrane homolog found HPASMC, through a signaling pathway involving Smad 2/3 not mitogen-activated protein...
The effects of lung transplantation on the survival and quality life in children with cystic fibrosis are uncertain.
Persistent hypoxia can cause pulmonary arterial hypertension that may be associated with significant remodeling of the arteries, including smooth muscle cell proliferation and hypertrophy. We previously demonstrated NADPH oxidase homolog NOX4 mediates human artery (HPASMC) by transforming growth factor-beta1 (TGF-beta1). now show increases HPASMC in vitro, accompanied increased reactive oxygen species generation gene expression, is inhibited antioxidants, flavoenzyme inhibitor...
Background. Osteoporotic fracture is a significant source of morbidity after lung transplantation. Therapies to prevent posttransplant are largely untested among transplant recipients. Methods. In this prospective uncontrolled study, referrals were assessed for bone health with metabolic, radiographic, and mineral density measurements. Transplant recipients treated an antiresorptive regimen that included bisphosphonate starting before or One year transplantation, the rate patients in each...
ABSTRACT The molecular methodologies used in our laboratories have allowed us to define a group of Nocardia isolates from clinical samples which resemble the type strain veterana . Three patient and N. gave identical distinctive restriction fragment length polymorphisms (RFLPs) for an amplified portion 16S rRNA gene. These three also RFLPs 65-kDa heat shock protein gene, but this pattern was that obtained nova strain. Sequence analysis both 1,359-bp region gene 441-bp showed 100% identities...
COVID-19 causes severe disease with poor outcomes. We tested the hypothesis that early SARS-CoV-2 viral infection disrupts innate immune responses. These changes may be important for understanding subsequent clinical obtained residual nasopharyngeal swab samples from individuals who requested testing symptoms at drive-through sites operated by University of Utah. applied multiplex immunoassays, real-time polymerase chain reaction assays and quantitative proteomics to 20 virus-positive...
Broncholithiasis can result in airway obstruction through the erosion of calcified lymph nodes into bronchial lumen or by extrinsic compression tracheobronchial tree. We report an unusual case broncholithiasis a patient with silicosis who developed from endobronchial polypoid masses granulation tissue adjacent to mediastinal nodes. The production may have been broncholiths early stages Efforts ablate polyps using YAG laser phototherapy were only temporarily successful and surgical removal...
Periprosthetic joint infection (PJI) can present challenges in diagnosis and treatment, particularly the setting of atypical causative organisms such as fungi mycobacteria. Herein, we a case provide review treatment an unusual PJI caused by bacillus Calmette-Guérin, administered during bladder cancer 3 years prior to total knee arthroplasty subsequent PJI. Although patient's history was known, neither his Bacillus Calmette-Guérin nor its potential for distant site spread that could lead were...
Herpes simplex-1 virus (HSV-1) reactivation in the respiratory tract is common intensive care unit (ICU) patients. However, susceptible ICU populations are poorly defined. Clinical recognition of HSV infection difficult and impact such not understood.A retrospective analysis HSV-1 positive patients encountered over a 5-year period at multispecialty was carried out. identified secretions using qualitative polymerase chain reaction (PCR) technique. Patient charts were reviewed for clinical...
Pediatric lung transplantation for cystic fibrosis has uncertain survival effects. Three retrospective studies disagree on benefit. The US Lung Allocation Score changed patient selection but confounds the analysis of outcomes. A prospective trial is needed to resolve clinical equipoise and explore quality-of-life