A5009675988- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Tracheal and airway disorders
- Nematode management and characterization studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumonia and Respiratory Infections
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Digestive system and related health
- Respiratory Support and Mechanisms
- Infections and bacterial resistance
- Pleural and Pulmonary Diseases
- Pancreatitis Pathology and Treatment
- Medical Imaging and Pathology Studies
- Antibiotic Resistance in Bacteria
- Sinusitis and nasal conditions
- Esophageal and GI Pathology
- Therapeutic Uses of Natural Elements
- Genomics and Rare Diseases
- Inhalation and Respiratory Drug Delivery
- Advanced Biosensing Techniques and Applications
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2010-2024
Université Laval
2017-2024
Louisiana State University Health Sciences Center New Orleans
2023
Montreal Heart Institute
2023
Background Elevated markers of systemic and pulmonary inflammation are associated with failure to recover lung function following exacerbations in people cystic fibrosis (pwCF). Our aim was determine whether adjuvant oral prednisone treatment would improve recovery forced expiratory volume 1 s (FEV ) % pred CF not responding antibiotic therapy. Methods This a randomised, double-blind, placebo-controlled trial pwCF treated intravenous antibiotics for exacerbation. At day 7, those who had...
Trikafta, a triple-combination drug, consisting of folding correctors VX-661 (tezacaftor), VX-445 (elexacaftor) and the gating potentiator VX-770 (ivacaftor) provided unprecedented clinical benefits for patients with most common cystic fibrosis (CF) mutation, F508del. Trikafta indications were recently expanded to additional 177 mutations in CF transmembrane conductance regulator (CFTR). To minimize life-long pharmacological financial burden drug administration, if possible, we determined...
BACKGROUND: Nasal polyposis (NP) is associated with a more severe and steroid-resistant asthma. OBJECTIVE: To compare clinical airway inflammatory features of asthmatics or without NP. METHODS: Two groups asthmatic patients were studied: group 1; n=39, NP; 2; n=40, Asthma control was assessed according to the Control Scoring System (ACSS). Expiratory flows, induced sputum, blood eosinophils also measured. RESULTS: ACSS score lower (poorer control) in 1 (meanA+-SEM = 73A+-3%) compared 2...
Cystic fibrosis (CF), caused by pathogenic variants in the CF transmembrane conductance regulator (CFTR), affects multiple organs including exocrine pancreas, which is a causal contributor to cystic fibrosis-related diabetes (CFRD). Untreated CFRD causes increased CF-related mortality whereas early detection can improve outcomes.Using genetic and easily accessible clinical measures available at birth, we constructed prediction model using Canadian Gene Modifier Study (CGS; n = 1,958)...
Patients with Cystic Fibrosis are subject to repeated respiratory tract infections, recent increasing isolation of unusual pathogens. Ralstonia species have lately been isolated at our institution, an organism historically frequently misidentified as Burkholderia or Pseudomonas. The prevalence spp. in cystic fibrosis populations has yet be determined, along its clinical implications. Seven patients out the 301 followed clinic had strains identified their tract. Most were multi-drug...
The development of COPD features, such as an incomplete reversibility airway obstruction (IRAO), in smoking or non-smoking asthmatic patients, a condition often named Asthma-COPD Overlap (ACO), has been recognized for decades. However, there is need to know more about the sub-phenotypes this according smoking.This study aimed at comparing clinical, physiological and inflammatory features patients exhibiting IRAO.In cross-sectional study, with IRAO (ACO, ≥20 pack-years) without (NS-IRAO, <5...
<h3>BACKGROUND:</h3> Exercise-induced O<sub>2</sub> desaturation contributes to dyspnea and exercise intolerance in various respiratory diseases. This study assessed whether automated titration was superior fixed-flow improve exertional walking endurance. We also aimed at evaluating possible additive effects of high-flow nasal cannula coupled with on these outcomes. <h3>METHODS:</h3> Subjects chronic diseases exercise-induced performed a 3-min constant-speed shuttle test (CSST) an endurance...
Over 400 variants in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) are CF-causing. CFTR modulators target to improve lung function, but marked variability response exists and current therapies do not address all CF-causing highlighting unmet needs. Alternative epithelial ion channel/transporters such as SLC26A9 could compensate for dysfunction, providing therapeutic targets that may benefit individuals with CF. We investigate relationship between rs7512462, a marker of...
Surgical lung biopsy (SLB) is considered in the investigation of interstitial diseases (ILDs) when a complete clinical evaluation and multidisciplinary discussion (MDD) do not allow clinician to make confident diagnosis. Owing risk procedure, an appropriate assessment risk/benefit ratio prior intervention recommended. We aimed assess postoperative outcomes diagnostic yield SLB for ILD tertiary care institution.We conducted retrospective cohort study consecutive subjects who underwent our...
Background: There is a need to characterize the impact of smoking status on clinical course asthmatics with incomplete reversibility airway obstruction (IRAO). Objective: To compare longitudinal health care use, symptom control, and medication needs between non-smoking IRAO. Materials methods: This was 12-month follow-up cross-sectional study comparing IRAO according their tobacco exposure. One group had exposure ≥20 pack-years considered have asthma-COPD overlap (ACO) second past Results: A...
<b>Introduction:</b> This study assesses the effects of automated oxygen titration, alone or with high flows on dyspnea and exercise tolerance in patients chronic lung disease exercise-induced O2 desaturation. <b>Methods:</b> Patients diseases desaturation were involved a 3 treatment arm cross-over to perform 3-min constant speed walk test (3min CSST) an endurance shuttle walking (ESWT) carried out one delivery systems: (1) at fixed-flow 2 L/min (2) titration system (FreeO2®) targeting 94%...
Abstract Background Over 400 variants in the cystic fibrosis (CF) transmembrane conductance regulator ( CFTR ) are CF-causing. modulators target to improve lung function, but marked variability response exists and current therapies do not address all CF-causing highlighting unmet needs. Alternative epithelial ion channel/transporters such as SLC26A9 could compensate for dysfunction, providing therapeutic targets that may benefit individuals with CF. Method We investigate relationship between...