A5075126452- Pharmaceutical Practices and Patient Outcomes
- Electronic Health Records Systems
- Patient Safety and Medication Errors
- Pharmaceutical studies and practices
- Animal Virus Infections Studies
- Healthcare Technology and Patient Monitoring
- Viral gastroenteritis research and epidemiology
- Quality and Safety in Healthcare
- Virus-based gene therapy research
- Bacterial biofilms and quorum sensing
- Tracheal and airway disorders
- Healthcare Systems and Technology
- Medication Adherence and Compliance
- Healthcare Policy and Management
- Social Media in Health Education
- Economic and Financial Impacts of Cancer
- Cystic Fibrosis Research Advances
- Medical Malpractice and Liability Issues
- Escherichia coli research studies
- Family and Patient Care in Intensive Care Units
Macquarie University
2022-2024
Westmead Institute
2019
Northport VA Medical Center
1991-1993
To compare medication errors identified at audit and via direct observation with reported to an incident reporting system paediatric hospitals investigate differences in types severity of detected by staff.
Limited evidence exists regarding medication administration errors (MAEs) on general paediatric wards or associated risk factors exists. The aim of this study was to identify nurse, medication, and work-environment with MAEs among inpatients. This a prospective, direct observational 298 nurses in referral hospital Sydney, Australia. Trained observers recorded details 5137 doses prepared administered 1530 children between 07:00 h 22:00 weekdays weekends. Observation data were compared charts...
Electronic medication management (eMM) systems are designed to improve safety, but there is little evidence of their effectiveness in paediatrics. This study assesses the short-term (first 70 days eMM use) and long-term (one-year) an system reduce prescribing errors, potential actual harm. We use a stepped-wedge cluster randomised controlled trial (SWCRCT) at paediatric referral hospital, with eight clusters for implementation. assess effects from additional random sample orders one-year...
Rotavirus is the most important worldwide cause of severe gastroenteritis. Extensive efforts have been devoted to design a vaccine that will prevent disease, but development more effective strategy may require progress in understanding mucosal immune response replicating viral antigens. In this article, we report characterization intestinal antibody murine model heterologous infection with rhesus rotavirus strain. We adapted enzyme-linked immunospot assay measure without difficulties...
We used an ELISPOT (enzyme-linked immunosorbent spot) assay to quantitate the long-term rotavirus-specific intestinal antibody response in a murine model. The frequency of antibody-secreting cells (ASCs) was followed for period 1 year after single dose rhesus rotavirus (10(6) PFU) administered at 10 days age. Some animals were boosted that time with second dose. One infection, virus-specific ASCs declined from acute-phase levels, but they still present significant levels (1.32 x 10(4) per...
We have adapted a murine model of heterotypic rotavirus infection for the purpose evaluating intestinal antibody response to an that mimics human vaccination. Neonatal mice were infected with rhesus (RRV). The enzyme-linked immunospot assay was used in order avoid common artifacts quantitation immune responses inherent measurements luminal or serum immunoglobulins and obtain easily quantifiable data flexible convenient format. Functionally active lymphocytes harvested from spleen, small...
Objectives Technology-related prescribing errors curtail the positive impacts of computerised provider order entry (CPOE) on medication safety. Understanding how technology-related (TREs) occur can inform CPOE optimisation. Previously, we developed a classification underlying mechanisms TREs using error data from two adult hospitals. Our objective was to update paediatric and assess reliability with which reviewers could independently apply classification. Materials methods Using 1696...
Parents and carers play a critical role in supporting their children while hospital. Multiple qualitative studies have explored parental involvement the care of hospitalised children. Administration medication to young can be difficult cause anxiety stress for are often willing able assist, yet little is known about how parents given responsibility administration We analysed data from prospective direct observational study nurses administering at major paediatric referral hospital Australia....
Medication prescribing in paediatrics is complex and compounded by the need to provide age weight related doses, errors continue be problematic. Electronic medication systems (EMS) can reduce through dosing calculators computerised decision support. However, evidence on costs benefits of these limited, particularly paediatric hospitals. This paper presents development a cost-benefit analysis (CBA) framework assess impact an EMS implementation tertiary hospital. An innovative component...
Electronic medication systems (EMS) improve safety in hospitals; however require modifications to optimize their performance. Drawing on a five-year program of research, we developed the Health Innovation Series disseminate recommendations arising from our research wide audience. Each issue contains EMS optimization tips that can be actioned by managers and system vendors, as well user for health professionals including nurses, doctors pharmacists. Five issues were released 30 Nov 2022, via...
The potential harm associated with medication errors is widely reported, but data on actual are limited. When has been measured, assessment processes often poorly described, limiting their ability to be reproduced by other studies. Our aim was design and implement a new process assess resulting from in paediatric inpatient care.
ABSTRACT Objectives Technology-related prescribing errors curtail the positive impacts of computerised provider order entry (CPOE) on medication safety. Understanding how technology-related occur can inform CPOE optimisation. Previously, we developed a classification underlying mechanisms using error data from two adult hospitals. Our objective was to update paediatric data, and assess reliability with which reviewers could independently apply classification. Materials Methods Using 1696...
Abstract Objectives To examine changes in technology-related errors (TREs), their manifestations and underlying mechanisms at 3 time points after the implementation of computerized provider order entry (CPOE) an electronic health record; evaluate clinical decision support (CDS) available to mitigate TREs 5-years post-CPOE. Materials Methods Prescribing (n = 1315) moderate, major, or serious potential harm identified through review 35 322 orders (immediately, 1-year, 4-years post-CPOE) were...
Abstract Objectives: To assess the immediate (first 70 days of use) and long-term (one-year) effectiveness an electronic medication management (eMM) system to reduce prescribing errors, their potential actual harm in paediatrics. Design : A stepped-wedge cluster randomised controlled trial (SWCRCT) over 11 weeks (April–July 2016): 8 clusters for eMM implementation. All orders during a random sample one-year post-eMM implementation (June–September 2017) were reviewed. Clinical errors rated...
The airways of people with cystic fibrosis (CF) are chronically colonised different pathogens. With recent interest in methicillin-resistant Staphylococcus aureus (MRSA), we have recently examined the rates MRSA colonisation groups within our CF Service. This paper now examines effectiveness eradication strategies to clear colonisation.