A5022898759- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Patient Safety and Medication Errors
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Electronic Health Records Systems
- Neurological Complications and Syndromes
- Neurogenetic and Muscular Disorders Research
- Pharmaceutical Economics and Policy
- Patient Satisfaction in Healthcare
- Congenital Anomalies and Fetal Surgery
- Healthcare Technology and Patient Monitoring
- Usability and User Interface Design
- Healthcare cost, quality, practices
- Immunodeficiency and Autoimmune Disorders
- Erythropoietin and Anemia Treatment
- Pregnancy and Medication Impact
- Model-Driven Software Engineering Techniques
- Renal Diseases and Glomerulopathies
- Advanced Database Systems and Queries
- Healthcare Quality and Management
- Pharmaceutical industry and healthcare
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Advanced Software Engineering Methodologies
Sydney Children’s Hospitals Network
2022-2024
Children's Hospital at Westmead
2007-2024
Sydney Children's Hospital
2019-2022
Royal Hospital for Women
2022
Prince of Wales Hospital
2022
Westmead Hospital
1992-2007
Queen Elizabeth Hospital
1998
Edinburgh Napier University
1998
Abstract Objective To provide a greater understanding of the tolerability, safety and clinical outcomes onasemnogene abeparvovec in real‐world practice, broad population infants with spinal muscular atrophy (SMA). Methods A prospective cohort study children SMA treated at Sydney Children's Hospital Network, Australia was conducted from August 2019 to November 2021. Safety included laboratory evaluations. Efficacy assessments World Health Organisation (WHO) motor milestones, oral swallowing...
Background Double-checking the administration of medications has been standard practice in paediatric hospitals around world for decades. While is widespread, evidence its effectiveness reducing errors or harm scarce. Objectives To measure association between double-checking, and occurrence potential severity medication (MAEs); check duration; factors associated with double-checking adherence. Methods Direct observational study 298 nurses, administering 5140 doses to 1523 patients, across...
Electronic medication management (eMM) systems are designed to improve safety, but there is little evidence of their effectiveness in paediatrics. This study assesses the short-term (first 70 days eMM use) and long-term (one-year) an system reduce prescribing errors, potential actual harm. We use a stepped-wedge cluster randomised controlled trial (SWCRCT) at paediatric referral hospital, with eight clusters for implementation. assess effects from additional random sample orders one-year...
Abstract Background To date, there is no national or international consensus on which key performance indicators ( KPIs ) should be used to measure hospital pharmacy performance. Aim explore pharmacists’ perspectives the role of and use their suggest a set for in Australian practice. Methods The study comprised two parts. Part A involved semi‐structured interviews with pharmacists from major Sydney metropolitan hospitals; were conducted until theme saturation was attained. B an online survey...
Abstract Aim The aim of this review was to explore the status key performance indicators ( KPIs ) in Australian hospital pharmacy practice. Data sources For narrative review, databases MEDLINE , PubMed and EBSCO were searched for relevant publications within period from April 1980 2014 using following search terms: pharmacy, indicators, measures, clinical benchmarking. inclusion criteria as follows: full text papers (papers only available abstracts discarded) English language. Reference...
Abstract A retrospective review of patients receiving rituximab off label in a large teaching hospital was conducted between July 2002 and January 2006. The indication, dosing regimen, efficacy cost were evaluated. Rituximab prescribed for three clinical indications; acute organ transplant rejection, post‐transplant lymphoproliferative disease autoimmune disease. On average, 600 mg weekly 4 weeks, costing the $108 739.37. We suggest an initial approval limited number doses with subsequent...
To evaluate the processes by which pharmaceuticals are added to formularies of Australian paediatric hospitals.Descriptive study and outcomes all submissions hospital drug therapeutics committees from 1 July 2010 31 December 2011.All eight tertiary hospitals in Australia.Interviews with committee secretaries or delegates document analysis.Total number formulary applications, stratified therapeutic class, approval rates for each quality supporting information.One hundred twenty applications...
While oral ganciclovir (OGCV) has been used as primary prophylaxis in patients at high risk for cytomegalovirus (CMV) infection after solid organ transplantation, its value secondary is unknown. We have examined the use of OGCV maintenance therapy following confirmed CMV on 16 occasions 15 patients, kidney (n = 4), kidney-pancreas 3) lung 6) and heart-lung 1) recipients. was two distinct clinical situations. One group 7) received consolidation (mean duration 21 +/- 5 d) i.v. induction acute...
The potential harm associated with medication errors is widely reported, but data on actual are limited. When has been measured, assessment processes often poorly described, limiting their ability to be reproduced by other studies. Our aim was design and implement a new process assess resulting from in paediatric inpatient care.
Abstract Background Cytotoxic medicine contamination of preparation and administration areas oncology healthcare facilities poses a risk to staff facing repeated low‐level exposure over time. The use closed‐system transfer devices (CSTDs) during cytotoxic products may reduce the levels contamination. primary aim was determine in hospitals that CSTDs compared those do not. Aim Method A retrospective, cross‐sectional study across four Australian conducted. determined via surface wipe sampling...
Abstract Objectives To examine changes in technology-related errors (TREs), their manifestations and underlying mechanisms at 3 time points after the implementation of computerized provider order entry (CPOE) an electronic health record; evaluate clinical decision support (CDS) available to mitigate TREs 5-years post-CPOE. Materials Methods Prescribing (n = 1315) moderate, major, or serious potential harm identified through review 35 322 orders (immediately, 1-year, 4-years post-CPOE) were...
<h3>Objective</h3> To describe and evaluate the decision-making processes for drug approval in Australian paediatric hospitals. <h3>Design</h3> Multicentre descriptive study involving face-to-face interviews of therapeutics committee chairs secretaries, review documents submissions all hospital committees over a 1-year period. <h3>Setting</h3> All eight hospitals Australia. <h3>Participants</h3> Eight seven secretaries or delegates. <h3>Main outcome measures</h3> Total expenditure, number...
Abstract Objectives: To assess the immediate (first 70 days of use) and long-term (one-year) effectiveness an electronic medication management (eMM) system to reduce prescribing errors, their potential actual harm in paediatrics. Design : A stepped-wedge cluster randomised controlled trial (SWCRCT) over 11 weeks (April–July 2016): 8 clusters for eMM implementation. All orders during a random sample one-year post-eMM implementation (June–September 2017) were reviewed. Clinical errors rated...
Introduction Hospitals play a significant and important role in funding high-cost medicines so patients can access treatments they need. High-cost are often specialty medicines, which contribute to increasing portion of the hospital budget. It is imperative that these expensive governed managed with fair, standardized evidence-based process. We aim provide framework for Drugs Therapeutics Committees (DTCs). Methods During 2021, Guiding Principles were developed following literature review...
P413 Aims: We performed a systematic review to evaluate different preparations of antibody immunosuppression used for induction therapy in pancreas and kidney/pancreas (SPK) transplantation. Methods: The Cochrane Central Register Controlled Trials, the Renal Group Specialist Register, MEDLINE, EMBASE, reference lists, abstracts conference proceedings scientific meetings were searched identify relevant randomised controlled trials (RCT) all languages (total 685). Studies independently...
Abstract Background Many studies have explored the effect of electronic medication management systems ( EMMS ) on doctors’ and nurses’ work, but few focused specifically pharmacists’ work. Aim This study examined how implementation a commercial affected work pharmacists in an Australian paediatric hospital. In particular, investigated whether any pharmacy tasks changed or were eliminated, new emerged following introduction. Methods Two rounds semistructured interviews with pharmacists, one 4...