A5050220711- Metal-Organic Frameworks: Synthesis and Applications
- Covalent Organic Framework Applications
- Catalytic C–H Functionalization Methods
- Advanced Polymer Synthesis and Characterization
- Membrane Separation and Gas Transport
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Advanced Biosensing Techniques and Applications
- Cancer therapeutics and mechanisms
- Synthesis and Catalytic Reactions
- Polymer Surface Interaction Studies
- ZnO doping and properties
- Catalytic Cross-Coupling Reactions
- Conducting polymers and applications
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- Axial and Atropisomeric Chirality Synthesis
- Computational Drug Discovery Methods
- Signaling Pathways in Disease
- Transition Metal Oxide Nanomaterials
- Metabolomics and Mass Spectrometry Studies
- Ion channel regulation and function
- Cancer Mechanisms and Therapy
Leibniz-Forschungsinstitut für Molekulare Pharmakologie
2017-2023
Karlsruhe Institute of Technology
2014-2016
Interface (United States)
2015
FIZ Karlsruhe – Leibniz Institute for Information Infrastructure
2015
Sanofi (Germany)
2010
For inorganic semiconductors crystalline order leads to a band structure which gives rise drastic differences the disordered material. An example is presence of an indirect gap. organic such effects are typically not considered, since bands normally flat, and band-gap therefore direct. Herein we show results from electronic calculations demonstrating that ordered arrays porphyrins reveal small dispersion occupied unoccupied leading formation We demonstrate herein structures can be fabricated...
Conjugated microporous polymers (CMPs) have attracted much interest due to their intrinsic porosity, outstanding stability, and high variability. However, the processing of these materials for membrane application has been limited insoluble nature when synthesized as bulk material. Here we report synthesis freestanding CMP-nanomembranes via layer-by-layer growth a "click" based conjugated polymer on sacrificial substrate. After dissolution substrate CMP-nanomembrane can be transferred porous...
Significance Protein–protein interactions mediated by proline-rich motifs are involved in regulation of many important signaling cascades. These belong to the most abundant recognition eukaryotic genome and preferentially adopt a left-handed polyproline helix II, secondary structure element that has been notoriously difficult mimic with small molecules. Here, we present structure-guided design effort yielding toolkit chemical entities enables rational construction selective molecule...
A structure-guided hybridization approach using two privileged substructures gave instant access to a new series of tankyrase inhibitors. The identified inhibitor 16 displays high target affinity on 1 and 2 with biochemical cellular IC50 values 29 nM, 6.3 nM 19 respectively, selectivity toward other poly (ADP-ribose) polymerase enzymes. shows favorable in vitro ADME profile as well good oral bioavailability mice, rats, dogs. Critical for the was utilization an appropriate linker between...
Abstract Bei anorganischen Halbleitern führt kristalline Ordnung zur Bildung einer elektronischen Bandstruktur, die deutliche Unterschiede zu ungeordnetem Material aufweist; z. B. können indirekte Bandlücken auftreten. organischen werden solche Effekte üblicherweise nicht in Betracht gezogen, da Bänder der Regel flach sind und Bandlücke daher direkt ist. Wir präsentieren hier genaue Berechnungen Struktur, zeigen, dass geordnete Porphyrinstrukturen eine geringe Dispersion besetzter...
Coupled up: A new general palladium-catalyzed procedure for the cross-coupling of aryl and heteroaryl tosylates is described. This highly versatile efficient process can be used synthesis a wide variety functionalized alkynes (see scheme).
The synthesis and surface modification of CMP thin films nanomembranes was performed using orthogonal click chemistries. can tune the nanomembrane properties for desired applications; use photo-initiated reactions provides additional opportunity to photo-pattern materials.
Transcription factor NF-κB potently activates anti-apoptotic genes, and its inactivation significantly reduces tumor cell survival following genotoxic stresses. We identified two structurally distinct lead compounds that selectively inhibit activation by DNA double-strand breaks, but not other stimuli, such as TNFα. Our do directly previously regulators of this pathway, most critically including IκB kinase (IKK), signal transmission in-between ATM, PARP1, IKKγ. Deconvolution strategies,...
Monolithic, crystalline and highly oriented coordination network compound (CNC) Prussian blue (PB) thin films have been deposited though different routes on conductive substrates. Characterization of the monolithic reveals a long-term stability, even after many redox cycles crystallinity as well high orientation remain intact during electrochromic switching process.
Metastasis is directly linked to poor prognosis of cancer patients and warrants search for effective anti-metastatic drugs. MACC1 a causal key molecule metastasis. High expression prognostic metastasis survival. Here, we developed novel small inhibitors targeting impede formation. We performed human promoter-driven luciferase reporter-based high-throughput screen (HTS; 118.500 compound library) identify transcriptional inhibitors. HTS revealed 1,2,3,4-tetrazolo[1,5-b]pyridazine-based...
The broader and systematic application of a novel scaffold is often hampered by the unavailability short reliable synthetic access. We investigated new strategy for design synthesis an array N2-substituted aza-2H-indazole derivatives as potential kinase inhibitors. Guided rational ligand alignment approach to qualify so-far underrepresented scaffold, indazoles were connected at N2 position with phenyl spacer arylsulfonamide or amide linkage. Initial profiling against panel 30 kinases...
In this study we investigated the influence of an organic polystyrene brush on deposition ZnO thin films under moderate conditions. On a non-modified SiO x surface, island growth is observed, whereas polymer induces homogeneous film growth. A chemical modification brushes during mineralization process occurs, which enables stronger interaction between then polar template and crystallites in solution. This may lead to oriented attachment so that observed (002) texture arises. Characterization...
The development of a novel selective synthesis 3-amino-2H-indazoles from readily available 2-halobenzonitriles is presented. reaction proceeds through domino sequence, consisting regioselective palladium-catalyzed coupling monosubstituted hydrazines with 2-halobenzonitriles, followed by an intramolecular hydroamination 5-exo-dig cyclization and subsequent isomerization to directly afford wide variety substituted 2H-indazole analogues in good excellent yields.
The preparation of cross-linked nanosheets with 1-2 nm thickness and predefined shape was achieved by lithographic immobilization trimethacryloyl thioalkanoates onto the surface Si wafers, which were functionalized 2-(phenacylthio)acetamido groups via a photoinduced reaction. Subsequent cross-linking free radical polymerization as well phototriggered Diels-Alder reaction under mild conditions on led to desired nanosheets. Electrospray ionization mass spectrometry (ESI-MS), X-ray...
CMP as large surface area materials have attracted growing interest recently, due to their high variability in the incorporation of functional groups combination with outstanding thermal and chemical stability, low densities. However, insoluble nature causes problems processing since usually applied techniques such spin coating are not available. Especially for membrane applications, where thin films is desirable, hindered commercial application. Here we describe interfacial synthesis on...
Abstract Identifying the protein targets of drugs is an important but tedious process. Existing proteomic approaches enable unbiased target identification lack throughput needed to screen larger compound libraries. Here, we present a interaction on photoactivatable cellulose membrane (CISCM) that enables several in parallel. To this end, use diazirine‐based undirected photoaffinity labeling (PAL) immobilize compounds membranes. Functionalized membranes are then incubated with extract and...
The accurate prediction of protein–ligand binding affinity belongs to one the central goals in computer-based drug design. Molecular dynamics (MD)-based free energy calculations have become increasingly popular this respect due their accuracy and solid theoretical basis. Here, we present a combined study which encompasses experimental computational studies on two series factor Xa ligands, enclose broad chemical space including large modifications scaffold. Using integrated approach,...
The application of surface-anchored metal-organic frameworks (SURMOFs) as highly porous host materials for molecules in the field nanoplasmonic sensing (NPS) is reported.SURMOFs are grown by a layer-bylayer procedure on surface NPS sensors, which consist quartz glass with SiO 2 coated gold nanodisks.As spectral position plasmon band depends refractive index surrounding medium, loading SURMOF pores guest results change effective and therefore shift plasmonic band.The combination SURMOFs that...
CMP as large surface area materials have attracted growing interest recently, due to their high variability in the incorporation of functional groups combination with outstanding thermal and chemical stability, low densities. However, insoluble nature causes problems processing since usually applied techniques such spin coating are not available. Especially for membrane applications, where thin films is desirable, hindered commercial application. Here we describe interfacial synthesis on...
Streng periodische Anordnungen …︁ von Porphyrineinheiten auf funktionalisierten Substraten können in Solarzellen mit bemerkenswerter Effizienz verwendet werden. In ihrer Zuschrift S. 7549 ff. zeigen J. Liu, C. Wöll und Mitarbeiter durch Berechnungen der elektronischen Struktur, dass solche Porphyrin-Anordnungen eine geringe Dispersion besetzter nichtbesetzter Bänder aufweisen, woraus kleine indirekte Bandlücke folgt. Die geordneten Metall-organischen Gerüste Porphyringruppen wurden mithilfe...