A5082085995- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Cancer Cells and Metastasis
- Neonatal Health and Biochemistry
- Helicobacter pylori-related gastroenterology studies
- Endoplasmic Reticulum Stress and Disease
- Digestive system and related health
- Heme Oxygenase-1 and Carbon Monoxide
Max Delbrück Center
2021-2023
Fondazione Italiana Fegato
2016
International Flame Research Foundation
2016
Transcription factor NF-κB potently activates anti-apoptotic genes, and its inactivation significantly reduces tumor cell survival following genotoxic stresses. We identified two structurally distinct lead compounds that selectively inhibit activation by DNA double-strand breaks, but not other stimuli, such as TNFα. Our do directly previously regulators of this pathway, most critically including IκB kinase (IKK), signal transmission in-between ATM, PARP1, IKKγ. Deconvolution strategies,...
Although the role of transcription factor NF-κB in intestinal inflammation and tumor formation has been investigated extensively, a physiological function sustaining epithelial homeostasis beyond not demonstrated. Using reporter mice, we detected strong activity Paneth cells, '+4/+5' secretory progenitors scattered Lgr5+ crypt base columnar stem cells small (SI) crypts. To examine functions SI self-renewal, mice or organoids ('mini-guts') with ubiquitously suppressed were used. We show that...
Abstract The interplay between NF-κB signaling and autophagy regulates inflammatory in different cellular contexts response to stimuli. impairment of this crosstalk may play a role chronic inflammation tumorigenesis. However, the molecular mechanism by which these two pathways interact regulate remains elusive. By using biochemical analysis imaging techniques, we characterized interaction endogenous autophagic marker LC3 NF-κB/p65 stress conditions. Following irradiation or TNFα stimulation,...
Abstract The interplay between NF-κB signaling and autophagy regulates inflammatory in different cellular contexts response to stimuli. impairment of this crosstalk may play a role chronic inflammation tumorigenesis. However, the molecular mechanism by which these two pathways interact regulate remains elusive. By using biochemical analysis imaging techniques, we characterized interaction endogenous autophagic marker LC3 NF-κB/p65 stress conditions. Following irradiation or TNFα stimulation,...