A5040903099- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Vascular Malformations Diagnosis and Treatment
- Retinal Development and Disorders
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Corneal surgery and disorders
- Neonatal Health and Biochemistry
- Optical Coherence Tomography Applications
- Neuroscience and Neural Engineering
- Ocular Surface and Contact Lens
- Ophthalmology and Eye Disorders
- bioluminescence and chemiluminescence research
- Advanced biosensing and bioanalysis techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sphingolipid Metabolism and Signaling
- Preterm Birth and Chorioamnionitis
- Retinoids in leukemia and cellular processes
- Drug-Induced Ocular Toxicity
- Diabetes Treatment and Management
National Taiwan University Hospital
2016-2025
National Taiwan University
2014-2025
National Yang Ming Chiao Tung University
2023
China Medical University
2023
China Medical University
2023
China Medical University Hospital
2023
Abstract This study evaluated the characteristic changes in optical coherence tomography (OCT) biomarkers neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor drugs and their relationship visual outcomes at 1-year follow-up a real-world setting. We retrospectively reviewed medical records of 126 eyes nAMD either intravitreal ranibizumab or aflibercept, including ophthalmologic examinations spectral-domain OCT baseline months 3, 6, 12 after...
Diabetic retinopathy (DR) is a major microvascular complication that can lead to severe visual impairment in patients with diabetes. The elevated oxidative stress and increased reactive oxygen species (ROS) production induced by hyperglycemia have been reported play an important role the complex pathogenesis of DR. Astaxanthin (AST), natural carotenoid derivative, has recently recognized as strong free radical scavenger might, therefore, be beneficial different diseases, including In this...
Purpose: To report findings and surgical outcomes of lamellar macular hole (LMH) or full-thickness (FTMH) accompanied by hole-associated epiretinal proliferation (LHEP) in eyes with high myopia (HM). Methods: Consecutive cases HM LMH FTMH containing LHEP were retrospectively reviewed (study group, 43 cases). Cases without (22) those non-HM (30) served as Control A B. Results: The study group showed larger (928.7 ± 381.9 μ m) deeper (remained base thickness: 79.7 23.7 retinal defect than that...
To quantitate the levels of various ceramide species in vitreous patients with proliferative diabetic retinopathy (PDR) and to investigate role vitreal ceramides pathogenesis PDR. A case control study. We collected samples from 25 type 2 diabetes PDR age- sex-matched nondiabetic controls undergoing vitrectomy. The (C16:0, 18:0, 20:0, 22:0, 24:1, 24:0) were measured by ultra-high-performance liquid chromatography-tandem mass spectrometry positive electrospray ionization mode. correlation...
This study documents the natural disease progression and genotype-phenotype correlation in RPGR-related retinitis pigmentosa (RP) Taiwanese population. A retrospective analysis was conducted on individuals with molecularly confirmed disease-causing variant(s). Demographics, best-corrected visual acuity (BCVA), spherical equivalent (SE), fundus autofluorescence, optical coherence tomography were assessed. Fifty-two from 31 families diagnosed Mean follow-up time 4.2 years. Among 21 genetic...
This single-centered, retrospective cohort study investigated the timing of involution retinopathy prematurity (ROP) and retinal vascularization to zone III after intravitreal bevacizumab (IVB) treatment its possible impacts on postnatal growth neurodevelopment. Premature infants with birth weight ≤1500 g, born between 2008 2014 diagnosed ROP were enrolled. All patients type 1 underwent IVB as 1st line recruited group; those any stage except without served controls. Neurodevelopmental...
This retrospective study evaluated the association of hyperreflective foci (HRF) with treatment response in diabetic macular oedema (DME) after anti-vascular endothelial growth factor (VEGF) therapy. The medical records, including ophthalmologic examinations and optical coherence tomography (OCT) images, 106 patients DME treated either intravitreal ranibizumab or aflibercept were reviewed. correlations between best-corrected visual acuity (BCVA) changes HRF along other OCT biomarkers...
To investigate choroidal neovascularization (CNV) characteristics after anti-vascular endothelial growth factor (anti-VEGF) therapy in patients with neovascular age-related macular degeneration by optical coherence tomography angiography (OCTA) and to assess the potential predictive role of combined qualitative quantitative biomarkers for disease activity. Patients diagnosed type 1 or 2 CNV via multimodal imaging who had received anti-VEGF treatment were retrospectively reviewed. Qualitative...
To investigate changes in the vitreoretinal interface after anti-vascular endothelial growth factor (anti-VEGF) treatment highly myopic eyes.Eyes with choroidal neovascularization (mCNV) treated intravitreal injection of anti-VEGF a single-center were retrospectively reviewed. Fundus abnormalities and features optical computed tomography studied.A total 295 eyes from 254 patients recruited to study. Prevalence macular retinoschisis (MRS) was 25.4%, rates progression onset MRS 75.9% 16.2%,...
To investigate the longitudinal changes in renal function and associated factors after intravitreal anti-vascular endothelial growth factor (VEGF) administration diabetic macular edema (DME). A total of 108 patients who had received ranibizumab or aflibercept for DME follow-up visits at least 2 years one hospital were retrospectively enrolled. The estimated glomerular filtration rate (eGFR) baseline during period receipt any replacement therapy recorded. Linear regression Cox models used to...
Foveal detachment associated with foveoschisis usually takes a progressive course, and is poor visual outcome. The purpose of this study was to report the spontaneous resolution foveal in patients myopic traction maculopathy without posterior vitreous detachment. A retrospective involving eight cases high myopia which subfoveal fluid had spontaneously resolved. clinical characteristics optical coherence tomography (OCT) findings were described. All involved predominant schisis outer retina,...
To evaluate the clinical characteristics and evolution of lamellar macular hole (LMH) in high myopia parameters associated with structural worsening, defined as development foveal detachment or full-thickness hole.Patients LMH were retrospectively recruited. The various optical coherence tomography identified at baseline during follow-up visits. Cox regression analysis was used to hazard ratios for hole.Among 112 eyes (98 patients), 64.3% female; mean axial length all 29.6 ± 1.9 mm. 'LMH...
To compare 2-year treatment outcomes of ranibizumab using treat-and-extend (T&E) or pro re nata (PRN) regimens for diabetic macular edema (DME) in clinical settings. We retrospectively enrolled 34 patients (34 eyes) with DME treated the T&E regimen, and PRN regimen matched to cases group by baseline best-corrected visual acuity (BCVA) central foveal thickness (CFT). BCVA CFT changes, number injections recurrence over 2 years were compared between groups. The average gain groups was 16.2 7.6...
To report the one-year outcomes of diabetic macular edema (DME) treated with ranibizumab under a real-life setting in Taiwan, and to identify prognostic factors.Between July 2013 January 2015, 119 eyes receiving intravitreal for DME were retrospectively recruited. Best-corrected visual acuity (BCVA) central foveal thickness (CFT) measured optical coherence tomography collected at baseline Month 3, 6, 12. Linear regression was used predicting factors changes BCVA CFT 12.The average number...
To analyze the associations between development of age-related macular degeneration (AMD) and regular use aspirin or non-aspirin non-steroidal anti-inflammatory drugs (NA-NSAIDs).
To evaluate the real-world efficacy of aflibercept using treat-and-extend (TnE) regimen in treating neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV), to analyze biomarkers optical coherence tomography (OCT) predict treatment outcomes.
Twenty-one consecutive patients (21 eyes) having proliferative diabetic retinopathy (PDR) and fibrovascular proliferation (FVP) with optical coherence tomography (OCT) available before after full-thickness macular hole (FTMH) formation were retrospectively reviewed. Four types of FTMH pathways in PDR identified quite different from those idiopathic conditions. The activity, severity locations FVP varied eyes destined to develop FTMHs. Type 1 was characterized by epiretinal membrane (ERM)...