A5091292374- Gut microbiota and health
- Reproductive System and Pregnancy
- Digestive system and related health
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Vitamin D Research Studies
- Bone Metabolism and Diseases
Nanjing University of Chinese Medicine
2022-2023
Background With increasing knowledge about the gut – bone axis, more studies for treatments based on regulation of postmenopausal osteoporosis by microbes are being conducted. Based our previous work, this study was conducted to further investigate therapeutic effects Lactobacillus rhamnosus GG (LGG) ovariectomized (OVX) model rats and immunological microecological mechanisms involved.Results We found a protective effect LGG treatment in OVX through changes microarchitecture, biomechanics,...
The traditional Chinese medicine Qing'e Pills (QEP) has been used to treat postmenopausal osteoporosis (PMO).We evaluated the regulatory effects of QEP on gut microbiota in osteoporosis.Eighteen female SD rats were divided into three groups: sham surgery (SHAM), ovariectomized (OVX) and treated with (OVX + QEP). Six weeks after ovariectomy, was administered OVX for eight (4.5 g/kg/day, i.g.). After 14 weeks, bone microstructure evaluated. Differences analysed via 16S rRNA gene sequencing....